Vladimir Berezin's research while affiliated with Abai Kazakh National Pedagogical University and other places

Publications (45)

Article
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Here, we report a metagenomic analysis of koumiss from Kazakhstan. In this study, shotgun metagenomic sequencing of the RNA and DNA viral community was performed.
Chapter
Extremophilic actinomycetes strains can survive extreme saline and alkaline environments and produce antimicrobial agents. In this chapter, we discuss laboratory methods that can be used to isolate and characterize actinomycetes strains capable of potentially producing novel antimicrobial agent(s) when cultured in conditions that mimic the environm...
Article
In 2019-2020, the Coronavirus (CoV) disease 2019 pandemic created a serious challenge for health care systems in several countries worldwide. A cure has not been developed yet and currently used treatment protocols are aimed at relieving clinical symptoms of the disease. This article presents a retrospective review of biologically active compounds...
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Microbial diversity studies regarding the aquatic communities that experienced or are experiencing environmental problems are essential for the comprehension of the remediation dynamics. In this pilot study, we present data on the phylogenetic and ecological structure of microorganisms from epipelagic water samples collected in the Small Aral Sea (...
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Here, we report the metagenomic analysis of the gut of Atelerix albiventris , an animal typically kept as a pet in Kazakhstan. In this case, shotgun metagenomic sequencing of the RNA and DNA viral community was performed.
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The ability of the Auricularia auricular-judae extract to suppress the reproduction of the influenza virus was studied. It was shown that the index of the therapeutic activity of the extract is comparable to that of commercial preparations Tamiflu and Remantadine.
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Monitoring of the presence of lactic acid bacteria phages in milk samples carried out using massive parallel sequencing technology. The presence of several groups of phages was identified, which shows that the method is promising for identifying phages in dairy products.
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Here, we present a virome analysis of the surface waters of the Small Aral Sea. In this case, shotgun metagenomic sequencing of the RNA and DNA virus community was used.
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The high variability of the influenza virus leads to its rapid adaptation to drugs and vaccines, which requires a change in the strategy and tactics against influenza infection. A deeper understanding of the nature of innate and adaptive immunity for influenza infection is required to create more effective means of influenza preventing and treating...
Article
The use of the nanocapsulated adjuvant Sapomax increased the expression of innate immunity genes (H2Q10, Ddx58, Tyk2, Tlr3, Tlr7, and TNF) responsible for the primary recognition of influenza virus, i.e., those belonging to the RLR and TLR families; genes involved in stimulating the production of type I and III IFN and pro-inflammatory cytokines; a...
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Here, we present a metagenomic analysis of the microflora of the surface waters of the Shardara reservoir, the largest artificial reservoir in Southern Kazakhstan, created to meet irrigation and hydropower engineering needs. In this case, shotgun metagenomic sequencing of the microbial community DNA was used.
Article
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Here, we describe the complete genome sequence of the Escherichia coli bacteriophage vB_EcoP_PR_Kaz2018, isolated from a water sample. vB_EcoP_PR_Kaz2018 is a linear double-stranded DNA T7-like podophage with a genome of 39,704 bp containing 45 predicted open reading frames (ORFs).
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Background: Commercially available antiviral drugs, when used in the treatment of viral infections, do not always result in success. This is an urgent problem currently that needs to be addressed because several viruses including influenza and paramyxoviruses are acquiring multi-drug resistance. A potential solution for this emerging issue is to c...
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Avian pathogenic Escherichia coli (APEC) bacteria are one of the main problems of the poultry industry. An effective way to combat colibacillosis is to use a phage preparation that lyses the bacteria. Here, we report the isolation of an E. coli -infecting phage, CEC_KAZ_2018, isolated from soil.
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Numerous studies have shown that immunostimulatory complexes containing Quil-A saponin and various antigens are effective in stimulating the immune response and can be used as vaccine preparations for animals and humans. However, Quil-A saponin possesses toxicity and haemolytic activity. In the present work, a saponin-containing preparation named “...
Article
Studies on the immunostimulating properties of saponins and methoxyflavonoids obtained from plants provides a theoretical basis for development of new immunopotentiators, thereby increasing effectiveness of immunotherapy and prophylaxis of viral infections. Expression of major genes of the immune response were significantly up-regulated upon introd...
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In recent years, there have been a number of reports on the successful use of immunostimulatory complexes with saponins and viral glycoproteins as veterinary vaccines and in clinical trials for human medicine. The saponins Algiox, Sapanox and Pangisan were isolated and purified by HPLC from Allochrusa gypsophiloides, Saponaria officinalis and Gypso...
Article
Newcastle disease virus (NDV) is an important pathogen in poultry. Waterfowl and a number of other avian species serve as the host for NDV. Severity of the disease is variable and infected animals mainly develop respiratory and neurological symptoms. Outbreaks of NDV in poultry are recorded regularly in the Republic of Kazakhstan despite the widesp...
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Viruses are the most abundant biological entities on Earth and can be found in a variety of environments. A high prevalence of viruses in marine and freshwater systems was initially reported by Spencer in 1955, but the ecological significance of viruses is insufficiently known even until the present day. Viruses are known to play a key role in the...
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Cyanobacteria of the genera Synechococcus and Prochlorococcus are an important contributors to photosynthetic productivity in the water ecosystems. The discovery of genes (psbA, psbD) that encode key photosystem II proteins (D1, D2) in the genomes of phages that infect these cyanobacteria suggests new models for the regulation, function and evoluti...
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Respiratory viruses are a major public health problem because of their prevalence and high morbidity rate leading to considerable social and economic implications. Cranberry has therapeutic potential attributed to a comprehensive list of phytochemicals including anthocyanins, flavonols, and unique A-type proanthocyanidins. Soy flavonoids, including...
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This article were studied nanoparticles assembled purified influenza virus hemagglutinin and neuraminidase antigens and low toxicity immunostimulating saponins Gg6 and Ah6, isolated from Kazakhstanian plants G.glabra and A.hippocastanum, in the animal vaccination/challenge experiments as delivery system for mucosal influenza subunit vaccine. Incorp...
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Isolates of Newcastle disease virus (NDV) from deceased wild and domestic pigeons in Kazakhstan were obtained from the Almaty region during 2005 and were genotypically analyzed by using reverse transcription polymerase chain reaction (RT-PCR) with primers specific to the viral fusion (F) protein gene. Part of the amplified F protein DNA product (nu...
Article
Although the important role of the non-structural (NS1 and NEP) gene of influenza A in virulence of the virus is well established, our knowledge about the extent of variation in the NS gene pool of influenza A viruses in their natural reservoirs in Kazakhstan is incomplete. 17 influenza A viruses of different subtypes were studied in this paper. Se...
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In this study was determinate the subtypes and prevalence of low-pathogenic influenza A viruses present on the territory of Kazakhstan in 2004-2006. Further was analyzed the HA and NA genes of these isolates in order to obtain a more detailed knowledge about the genetic variation of influenza A viruses in their natural hosts.
Article
Immunostimulating complexes (ISCOMs) are unique multimolecular structures formed by encapsulating antigens, lipids and triterpene saponins and are one of the most successful antigen delivery systems for microbial antigens. In the current study, both the route of administration and the antigen concentration of ISCOMs, containing Eimeria tenella anti...
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Newcastle disease virus (NDV) infects domesticated and wild birds throughout the world, and infections with virulent NDV strains continue to cause disease outbreaks in poultry and wild birds. To assess the evolutionary characteristics of 28 NDV strains isolated from chickens in Kazakhstan and Kyrgyzstan during 1998, 2000, 2001, 2003, 2004, and 2005...
Article
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Immunostimulating complexes (ISCOMs) are unique, multimolecular structures formed by encapsulating antigens, lipids, and triterpene saponins of plant origin, and are an effective delivery system for various kinds of antigens. The uses of ISCOMs formulated with saponins from plants collected in Kazakhstan, with antigens from the poultry coccidian pa...
Article
Immunostimulating complexes (ISCOMs) are unique, multimolecular structures formed by encapsulating antigens, lipids and triterpene saponins of plant origin, and are an effective delivery system for various kinds of antigens. The uses of ISCOMs formulated with saponins from plants collected in Kazakhstan and with antigens from the poultry coccidian...
Article
Full-text available
Newcastle disease virus (NDV) infects domesticated and wild birds throughout the world and has the possibility to cause outbreaks in chicken flocks in future. To assess the evolutionary characteristics of 10 NDV strains isolated from chickens in Kazakhstan during 1998 we investigated the phylogenetic relationships among these viruses and viruses de...
Article
The immunostimulating activity of saponin-containing extract of Saponaria officinalis has been studied. Use of an S. officinalis extract in a concentration close to the critical concentration of saponin micella formation increased the immunogenicity of viral glycoproteins. The immunogenicity of glycoprotein complexes with S. officinalis was higher...
Article
The sensitivity of the peroxidase reaction in dot-blot ELISA significantly depends on the substrate. The highest sensitivity is observed using benzidine and diamine-phenol combinations as the substrates due to the reaction of the coupled oxidation (NADI).

Citations

... More in-depth studies have been carried out on the shrinkage of the Aral Sea [22][23][24], the microbiome of the Aral Sea [25][26][27], and the ecological environment of the basin [28][29][30][31][32]. The research on lake sediments has become more abundant, e.g., environmental reconstructions of the salt water, geological structure, etc. through biological indicators [33][34][35]; the use of sedimentary records of titanium changes to restore the wind intensity and frequency characteristics of western Central Asia since the Late Holocene [36]; the ecological risk assessment of potentially toxic elements in the North Aral Sea [16]; etc. ...
... Mineralization reactions involve Converting CO2 to bicarbonate, then precipitating mineral carbonates in the presence of divalent metal ions at an alkaline pH,. The only disadvantage is the sluggish rate of CO2 hydration, which renders the whole process exceedingly slow and limits the technology's usefulness in CO2 sequestration at ambient temperatures and pressures (55,58,61,62). A biomimetic technique using a biocatalyst called carbonic anhydrase (CA), a highly efficient enzyme that catalyses the reversible hydration of CO2 into bicarbonate, can speed up CO2 mineralization (63). ...
... Diammonium glycyrrhizinate (DG) is an ammonium salt of glycyrrhizic acid that is used medically in China as a third generation of glycyrrhizic acid [20]. Saponins isolated from licorice have been reported to stimulate high levels of humoral and cellular immunity [21,22]. ...
... It displays spermicidal activity due to the presence of saponins (Primorac et al., 1985). Moreover, it can be used as an adjuvant for veterinary vaccines (Turmagambetova et al., 2017). Medicinal herbs have historically been applied to various diseases, particularly in Asian countries (Tyler, 2000). ...
... This study indicates that velogenic NDV infection interferes with the intestinal microbiome in quails. The intestinal microflora is relatively stable under common circumstances but is easily influenced by various diseases (Ma et al., 2017).NDV is the causative agent of ND, which is one of the most highly contagious diseases in chickens, and result in severe economic losses to the poultry industry worldwide (Turmagambetova et al., 2017). In Iran, NDV is endemic in different parts of the country, causing enormous losses due to high mortality, sub-optimal production, slaughterhouse condemnation of carcasses, and high prevention and treatment expenses. ...
... Blanco et al. (2019) [25] investigated the occurrence of Alpha-and Beta-coronavirus in surface waters in Central Saudi Arabia, using a broad-range RT-PCR, detecting only 1 sample out of 21 positive for Alphacoronavirus. Some metagenomic studies permitted the detection of Coronaviridae in surface water (river, lake, and water reservoir) [26]. Amplification of SARS-CoV-2 viral RNA in rivers downstream the Milano Metropolitan area, Italy, during the COVID-19 epidemic peak, was reported by Rimoldi et al. (2020) [27]. ...
... Pour une application cutanée, l'utilisation de l'huile essentielle peut donc se faire sans traitement supplémentaire. Il y a actuellement un intérêt grandissant pour la capacité antivirale des huiles essentielles (Jassim and Naji, 2003 ;Turmagambetova et al., 2015). Les huiles essentielles ayant une activité répulsive n'avaient jamais été envisagées dans le contexte cutané comme antiviraux. ...
... Additionally, when utilized in conjunction with neuraminidase inhibitors, the IC50′s of zanamivir and oseltamivir were reduced. Other studied functional foods for the influenza virus include several berries (raspberry, strawberry, lingonberry, and bilberry), soy proteins, and broccoli sprouts [120][121][122]. Broccoli sprouts are rich in precursors for sulforaphane antioxidants, which may affect natural killer cells to downregulate the influenza virus RNA level and lower the infection [122]. ...
... A possible indication that the extract could be having an immunomudulating activity. [15,18,19,20] reported that saponnins possess immunostimulatory activity and since saponnins were found in high quantity in the extract of PPOJ5, they could be responsible for the increase in the lymphocyte count in the groups treated with PPOJ5. This plant extract thus requires evaluation for their immunostimulatory or antiretroviral activity. ...
... The saponin used in this study might act as immunostimulant as reported in other studies. In this regards, Berezin et al. [34], demostrated significant increase in antibody-(IgG, IgM and IgA) and cell mediated (IFN-gamma and IL2) immune responses following single intranasal immunization against influenza using saponin nanoparticle based delivery. Similarly, Yu et al. [35], reported the use of oral ginseng stem-leaf saponins (GSLS) to enhanced vaccine induce response in immunosuppressed chickens. ...