Vincent Schweinsberg's research while affiliated with Ruhr-Universität Bochum and other places

Publications (5)

Article
The interferon-stimulated gene 15 (ISG15) plays an important role in the pathogenesis of hepatitis C virus (HCV) infection. ISG15-regulated proteins have previously been identified that putatively affect this proviral interaction. The present observational study aimed to elucidate the relation between ISG15 and these host factors during HCV infecti...
Article
Hepatic fibrosis and cirrhosis are major health problems worldwide. Up to now, highly invasive biopsy remains the diagnostic gold standard despite many disadvantages. In order to develop non-invasive diagnostic assays for the assessment of liver fibrosis it is urgently necessary to identify molecules which are robustly expressed in association with...

Citations

... 12 Furthermore, upregulated expression of ISG15 was observed at both the mRNA and protein levels in liver tissue samples from patients with HCV infection compared to the levels detected in uninfected controls. 13 Similarly, the abundance of ISG15 transcripts was found to be increased in human PBMCs and liver cells in patients with HCV infection who were unresponsive to IFN treatment compared to the levels in corresponding IFN-responsive patients. 14 In addition, high levels of ISG15 in the liver of patients with HCV infection were associated with an unfavourable HCV genotype 1, a high hepatic HCV load and a low antiviral response to IFN compared to patients who did not present such characteristics. ...
... Among the genes that increase in accessibility, we focused on those that exemplify the largest gain in accessibility by selecting the top 25th percentile of change in accessibility and lower 25th percentile of read counts in the control sample (Fig. 6A). Among those were homologs of known human liver fibrosis markers such as Apolipoprotein A-IV [54] or Fibulin-5 [55] (Fig. 6C, D). In clusters G and H we observe a decrease in promoter accessibility (Fig. 4D, Supp. ...