Vincent Schweinsberg's research while affiliated with Ruhr-Universität Bochum and other places

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Publications (5)

Hepatic expression of proteasome subunit alpha type-6 is upregulated during viral hepatitis and putatively regulates the expression of ISG15 ubiquitin-like modifier, a proviral host gene in hepatitis C virus infection
Article
  • Feb 2016
The interferon-stimulated gene 15 (ISG15) plays an important role in the pathogenesis of hepatitis C virus (HCV) infection. ISG15-regulated proteins have previously been identified that putatively affect this proviral interaction. The present observational study aimed to elucidate the relation between ISG15 and these host factors during HCV infecti...
Supplementary Material - Analysis of disease-associated protein expression using quantitative proteomics – Fibulin-5 is expressed in association with hepatic fibrosis
Data
  • Dec 2015
Patienten mit einer Virushepatitis weisen eine Induktion in der hepatische Expression der Proteasom alpha-Untereinheit Typ-6 (PSMA6) auf, welche wiederum die Expression proviraler Wirtsgene der Hepatitis-C-Virus-Infektion reguliert
Article
  • Aug 2015
Analysis of Disease-Associated Protein Expression Using Quantitative Proteomics—Fibulin-5 Is Expressed in Association with Hepatic Fibrosis
Article
  • Mar 2015
Hepatic fibrosis and cirrhosis are major health problems worldwide. Up to now, highly invasive biopsy remains the diagnostic gold standard despite many disadvantages. In order to develop non-invasive diagnostic assays for the assessment of liver fibrosis it is urgently necessary to identify molecules which are robustly expressed in association with...
P0696 : Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection
Article
  • Jan 2015

Citations

... 12 Furthermore, upregulated expression of ISG15 was observed at both the mRNA and protein levels in liver tissue samples from patients with HCV infection compared to the levels detected in uninfected controls. 13 Similarly, the abundance of ISG15 transcripts was found to be increased in human PBMCs and liver cells in patients with HCV infection who were unresponsive to IFN treatment compared to the levels in corresponding IFN-responsive patients. 14 In addition, high levels of ISG15 in the liver of patients with HCV infection were associated with an unfavourable HCV genotype 1, a high hepatic HCV load and a low antiviral response to IFN compared to patients who did not present such characteristics. ...
Reference: Organizing gene literature retrieval, profiling, and visualization training workshops for early career researchers
Hepatic expression of proteasome subunit alpha type-6 is upregulated during viral hepatitis and putatively regulates the expression of ISG15 ubiquitin-like modifier, a proviral host gene in hepatitis C virus infection
Citing article
  • Feb 2016
... Among the genes that increase in accessibility, we focused on those that exemplify the largest gain in accessibility by selecting the top 25th percentile of change in accessibility and lower 25th percentile of read counts in the control sample (Fig. 6A). Among those were homologs of known human liver fibrosis markers such as Apolipoprotein A-IV [54] or Fibulin-5 [55] (Fig. 6C, D). In clusters G and H we observe a decrease in promoter accessibility (Fig. 4D, Supp. ...
Reference: Multi-omics analyses of early liver injury reveals cell-type-specific transcriptional and epigenomic shift
Analysis of Disease-Associated Protein Expression Using Quantitative Proteomics—Fibulin-5 Is Expressed in Association with Hepatic Fibrosis
Citing article
  • Mar 2015
  • PubMed