November 2022
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53 Reads
World Journal of Pharmaceutical Research
The cytotoxicity studies of the nutraceutical products, especially the lactobacillus (LAB) formulation are gaining importance due to its industrial application. To support the claim MTT test was performed on three different strains of Lactobacillus i.e. Lp-Lactobacillus plantarum; Lr-Lactobacillus rhamnosus and La-Lactobacillus acidophilus. The viability study conducted by MTT assay on HCT 115 cell lines shows a decrease in percentage cell viability, an approximately around 40% in case of the Lp for its highest dose of 50 µg/ml and further, showing the strongest anti-proliferative activity as compared to control group. SHORT COMMUNICATION The pharmacology research, for the evaluation of the toxicity, is become vital in regards to the neutraceuticals products development 1-7. The cytotoxicity studies of the nutraceutical products, especially the lactobacillus (LAB) formulation is gaining importance due to its industrial application 11-12. The interaction of the probiotics cells with the living host cells may rarely precipitate toxicity 13-18. The interaction of the LAB in pathophysiological conditions such as cancer is gaining importance as an alternative source of functional food 14-16. To support the claim MTT test was performed on three different strains of Lactobacillus i.e. Lp-Lactobacillus plantarum; Lr-Lactobacillus rhamnosus and La-Lactobacillus acidophilus. The culture of Lp and La were discovered by our team from sheep milk and whole genome