Victor N'Goka

Marien Ngouabi University · Department of Chemistry

Oxidative stress and inflammation play a key role in the occurrence of neurodegenerative diseases. Traditionally, Pentaclethra eetveldeana leaves are used in dementia treatment. Therefore, this study aimed to evaluate the antioxidant and anti-inflammatory activities as well as the phytochemical composition of Pentaclethra eetveldeana leaves from fo...

Main research studies have been conducted on vector control for the fight against malaria, a very devastating disease in sub-Saharan Africa. This study was designed to carry out larvicidal and ovicidal activities of some chemical constituents of essential oils. Eleven compounds including related derivatives have been either purchased or synthesized...

An alternative method to obtain petroleum ether equivalent is described in this study. Two fractions of benzin were obtained, by fractional distillation of available and less expensive benzin, with yield of 13.78 and 18.44% or 32.22% the both. The aptitude of the first fraction was investigated to extract fat. Comparative extractions were done agai...

The triacylglycerols and fatty acids composition of the oils of the Bellicositermes natalensis Haviland obtained from two different regions of Congo were qualitatively and quantitatively determined by gas chromatography/SM. This insects contained oil in the range of 48-53% dry matter, comparable with oleaginous plants like palm tree (45-50%), peanu...

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Nipecotic acid derivatives bearing an aryl iminoxymethyl side chain at the position 6 were synthesised and tested for their GABA uptake inhibitory properties. Contrarily to the N-substituted derivatives 2, 3 the introduction of the oxime function in the side chain of analogues of the active nipecotic derivative 4 does neither increase, nor maintain...

The hydrolysis of the meso-cyclopropane-1,2-dicarboxylates 1a-3a, 4, 5a, 6a, and 9, containing various substituents at C(3), and of the rac-3-phenylcyclopropane-1,2-dicarboxylates7a, 8a, and 10 with pig liver esterase (PLE) is described. The stereoselectivtty and absolute configurations of the products were determined. An interpretation of results...

6-aralkylether- and 6-arylenol-ether-substituted nipecotic acids were synthesized. These analogues are poor GABA uptake inhibitors. The electronegative region concept developed in the N-substituted nipecotic acid series cannot be transferred on the side chain of this series of 6-substituted analogues.

A model for the pharmacophore of GABA-uptake inhibitors was established using published structure-activity data and molecular modeling. The model accounted for the activities of different classes of GABA-uptake inhibitors. Analogues of guvacine substituted at position 6 were synthesized in order to confirm the model. 6-(3,3-Di-phenylpropyl)guvacine...

Les analogues de l'acide nipécotique, substitué dans les positions 2, 3, 4, 5 et 6 par un reste méthyle ou phényle, ont été préparés. Leurs affinités pour le système de transport du GABA et les sites récepteurs du GABA ont été déterminés. On observe que l'influence favorable des substituants méthyle ou phényle sur la lipophilie est contrariée par d...