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Several studies show a correlation between intestinal microbiota disturbances and metabolic disorders, including type 2 diabetes mellitus (T2DM). Fatty liver is one of the complications that occurs due to T2DM. Fatty liver is characterized by the accumulation of lipids in the liver in response to increased triglyceride synthesis in hepatocytes and is thought to be associated with disturbances in the gut microbiota so that changes in the gut microbiota can be a potential target for T2DM treatment. It is known that inulin, a prebiotic, can improve intestinal microbiota disorders. This study aims to analyze the effect of administering inulin from dahlia tubers on fatty liver in T2DM rats.The research design is an experimental study with a post-test-only control group design conducted from June to November 2023. The study used twenty male Rattus norvegicus Wistar strain divided into five groups: a control group, a T2DM-induced group, T2DM groups given inulin extract at doses of 0.5 mg/gBW, 1.0 mg/gBW, and 1.5 mg/gBW. The results showed that the T2DM group had a higher significant percentage of fatty liver (p <0.01) than the control group. Compared to the T2DM group, there was a decrease in the percentage of fatty liver in the T2DM groups given inulin at all doses (p<0.05). This study concluded that inulin administration can reduce fatty liver in T2DM rats. Keywords : Dahlia tubers., fatty liver., inulin., type 2 diabetes mellitus
Background
Dahlia (Dahlia variabilis), a widely cultivated ornamental plant in Indonesia, is known to contain 84.08% inulin in its tubers. Numerous studies have demonstrated the antidiabetic potential of inulin from various plant sources. However, most of the research is in the form of a mixture of inulin with other active substances, and no one has analyzed the effects of inulin derived from dahlia tubers. This study examines the effect of inulin from dahlia tuber extract on blood glucose levels, serum insulin expression, pancreatic tissue insulin expression, homeostatic model assessment of insulin resistance (HOMA-IR), and the extent of insulitis in diabetic rats.
Methods
In this experimental study, 20 male Wistar rats were randomly allocated to five groups. Group I served as the control, Group II as the STZ-induced diabetic group, Group III as the STZ-induced diabetic group treated with inulin (0.5 g/kgBW), Group IV as the STZ induced diabetic group treated with inulin (1.0 g/kgBW), and Group V as the STZ-induced diabetic group treated with inulin (1.5 g/kgBW). The inulin was administered for 21 days. The degree of insulitis was evaluated using a scoring system, serum insulin concentration via ELISA, and insulin expression in the pancreas through immunohistochemistry.
Results
Administration of inulin from dahlia tubers significantly reduced serum glucose concentrations in diabetic rats. Notably, only inulin extracts at doses of 1 g/kgBW and 1.5 g/kgBW showed a significant reduction in insulitis and HOMA-IR index in diabetic rats, while the 0.5 g/kgBW inulin extract reduced insulitis without affecting HOMA-IR. Inulin extract administration did not affect insulin expression in serum or pancreatic tissue.
Conclusions
Inulin from dahlia tuber can exert antidiabetic properties by improving insulin resistance and insulitis. These studies suggest the great potential of dahlia tubers as the source of inulin for prebiotic functional foods.
One of plants with tubers that is rich of Inulin is well known as Dahlia. Inulin obtained in Dahlia is consisted of fructose monomers which are natural polymers and are linked by linear -2,1-fructosyl-fructose bonds. The aim of this study was to extract inulin from dahlia tubers, determine the moisture content and degree of purity of inulin from dahlia tubers. This study was conducted experimentally at the Research Laboratory of STIKes Payung Negeri Pekanbaru and STIFAR Riau. Inulin was characterized qualitatively and quantitatively including the Seliwanof test, determination of water content (Moisture Balance method), determination of inulin yield and determination of the degree of purity of inulin using High Performance Liquid Chromatography (HPLC). The object of this study was the ornamental dahlia plant obtained from Bukittinggi, West Sumatra. Dahlia bulb extraction results obtained inulin yield of 0.47% (w/w) with a yellowish white color. Qualitative test with Seliwanoff's reagent showed positive results indicated by the formation of a red color which indicated that inulin was positive for fructose. The research results indicated that the content of water percent dry weight (bk) of inulin itself was 4.53%. Quantitative analysis was performed using HPLC at a wavelength of 210 nm. The HPLC chromatogram showed that dahlia tubers had an inulin content of 84.08%, lower than the commercial inulin of Chicory Merck Orafti®GR. Moreover need further research and analysis using Gas Cromatography (GC) so that the degree of inulin polymerization can be determined.
p> Manusia membutuhkan nutrisi untuk memenuhi kebutuhan tubuh seperti karbohidrat, protein, lemak, vitamin dan mineral. Perubahan gaya hidup dan pola konsumsi pangan masyarakat berpengaruh terhadap peningkatan penyakit degeneratif seperti diabetes mellitus (DM). Konsumsi serat dari pati resisten/resistant strach (RS) sangat diperlukan untuk mencegah DM. RS merupakan salah satu pangan hasil modifikasi yang berpotensi sebagai ingredient pangan fungsional. Ganyong merupakan pangan sumber karbohidrat yang mudah ditanam yang dapat dijadikan pangan alternatif bagi penderita DM dengan memodifikasi pati ganyong menjadi RS sehingga mengurangi kandungan indeks glikemiknya (IG). Penelitian ini bertujuan untuk mengetahui kadar abu, air, protein, karbohidrat, lemak dan serat kasar RS ganyong termodifikasi. Pengolahan pati ganyong menjadi RS dilakukan dengan metode autoclaving-cooling dengan 3 siklus pada suhu 130oC dan analisis proksimat mengacu pada metode pengujian SNI 01-2891-1992. Hasil analisis proksimat RS ganyong dibandingkan dengan pati ganyong memperlihatkan peningkatan kadar abu (0,68%), protein (0,56%), lemak (0,28%) dan serat kasar (6,61%), sementara kadar air dan karbohidrat mengalami penurunan yaitu 9,38% dan 74,25%. Dapat disimpulkan bahwa RS ganyong bisa digunakan sebagai pangan alternatif pada pasien DM karena semakin tinggi nilai kadar serat, protein dan lemak suatu pangan, maka nilai IG semakin rendah. Bagi penderita DM dapat memilih produk pangan yang akan dikonsumsi yang memiliki IG rendah dengan ciri tingginya nilai serat pangan total, lemak dan protein.
Humans need nutrients to fulfill the body’s need such as carbohydrates, proteins, fats, vitamins and minerals. Changes in lifestyle and patterns of food consumption affect the increase in degenerative diseases such as diabetes mellitus (DM). Consumption of fiber from resistant starch is very necessary to prevent DM ,. Resistant starch (RS) is a modified food that has the potential as a functional food ingredient. Arrowroot is a food source of carbohydrates that is easily planted that can be used as an alternative food for people with DM by modifying arrowroot starch into RS thereby reducing the content of the glycemic index (GI). The purpose of this research was to determine ash content, water content, protein, carbohydrates, fat and crude fiber arrowroot RS modified by autoclaving cooling. The procedure of arrowroot starch into RS is carried out by autoclaving cooling method with 3 cycles at 130oC. Proximate analysis conducted refers to the SNI 01-2891-1992 testing method. The results of proximate analysis of arrowroot RS compared to arrowroot starch showed increased levels of ash (0,68%), protein (0,56%), fat (0,28%) and crude fiber (6,61%), while water and carbohydrate content decreased 9,38% and 74,25% respectively. The results showed that arrowroot RS can be used as an alternative food in DM patients because the higher the value of fiber, protein and fat of a food, the lower the GI value. For patients of DM can choose food products that will be consumed that have a low GI with a high value of total food fiber, fat and protein. </p
p> Tujuan dari penelitian ini adalah untuk mengetahui pengaruh substitusi ampas tahu terhadap kualitas kimia dan mengetahui tingkat penerimaan panelis terhadap uji organoleptik dari nugget ayam yang dihasilkan. Rancangan penelitian yang digunakan adalah Rancangan Acak Lengkap (RAL) dengan 4 perlakuan substitusi tepung ampas tahu yaitu 0%, 10%, 20% dan 30% dengan dua ulangan. Analisis hasil kualitas kimia (karbohidrat, protein, lemak, kadar abu dan kadar air) dilakukan dengan menggunakan One Way Anova dan uji Kruskal-Wallis untuk uji organoleptik dengan taraf 5%. Hasil analisis menunjukkan bahwa tidak ada pengaruh substitusi tepung ampas tahu yang signifikan terhadap kualitas kimia nugget ayam (p > 0,05). Hasil uji organoleptik diperoleh nugget ayam yang paling disukai adalah substitusi tepung ampas tahu 10%. Analisis data menunjukkan tidak terdapat perbedaan yang signifikan terhadap aroma dan tekstur nugget ayam yang dihasilkan (p > 0,05). Sedangkan analisis terhadap rasa nugget ayam memperlihatkan perbedaan yang signifikan (p < 0,05) antara dua kelompok, sehingga analisis dilanjutkan dengan uji Man-Whitney dan didapatkan hasil kelompok yang mempunyai perbedaan rasa adalah antara kelompok substitusi tepung ampas tahu 0% dengan 30% dan antara kelompok 10% dengan 30%. Dari hasil penelitian ini dapat disimpulkan bahwa tepung ampas tahu dapat dimanfaatkan sebagai bahan substitusi dalam pengolahan nugget ayam dengan tidak mengurangi nilai gizinya.. </p
... The findings confirmed that dahlia tubers contain 84.08% inulin. The production of inulin was achieved through an extraction process, and a proximate analysis of the inulin revealed its composition, including water content (6.75%), ash content (0.39%), crude protein (0.95%), fat (0.49%), carbohydrates (91.41%), and natural fiber (0.97%) [14,15]. Research on inulin from dahlia tubers is essential for advancing inulin as a functional food for individuals with type 2 diabetes. ...
... Most of the identifed compounds have good biological activity, such as, cafeic acid, gallic acid, gentisic acid, ferulic acid, and other phenolic compounds. Moderate intake of these compounds can present promising efects in the prevention of diseases [17,[39][40][41] such as diabetes, obesity, Parkinson's, cardiovascular disease, and others. In view of antioxidant activity, these compounds can be developed as natural food additives [31,42,43]. ...
... Faktor yang sangat berpengaruh pada kualitas produk pangan adalah kadar air karena kadar air dalam suatu bahan pangan dapat berdampak pada daya simpannya karena dengan semakin rendahnya kadar air mikroba semakin terhambat (Naufalin et al., 2013). Kadar air pada nugget sangat dipengaruhi senyawa kimia, konsitensi, suhu, dan interaksi dengan komponen penyusun makanan seperti lemak, protein, vitamin, asam lemak bebas, dan komponen lainnya (Putri, 2018). Berdasarkan hasil uji statistik one way anova diketahui bahwa perlakuan pada formulasi nugget ikan patin dan bayam hijau berpengaruh nyata terhadap kadar air nugget. ...
... Makanan jajanan yang terpapar debu dan lalat dapat menyebabkan penyakit pada sistem pencernaan, terutama jika alat makan tidak dicuci dengan bersih karena keterbatasan air. Hal ini dapat menyebabkan penyakit pada konsumen, termasuk anak-anak (Dyna et al., 2018). ...