Valerie Leysen's research while affiliated with Université de Lille and other places

Publications (10)

Article
The nitric oxide (NO) signaling pathway in hypothalamic neurons plays a key role in the regulation of the secretion of gonadotropin-releasing hormone (GnRH), which is crucial for reproduction. We hypothesized that a disruption of neuronal NO synthase (NOS1) activity underlies some forms of hypogonadotropic hypogonadism. Whole-exome sequencing was p...
Article
At the present time, no viable treatment exists for cognitive and olfactory deficits in Down syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive nonreproductive neurological symptoms closely parallel a postpubertal decrease in hypothalamic as well as extrahypothalamic expression of a master molecule that controls reproduction-...
Article
Full-text available
In adult mammals, neural stem cells are localized in three neurogenic regions, the subventricular zone of the lateral ventricle (SVZ), the subgranular zone of the dentate gyrus of the hippocampus (SGZ) and the hypothalamus. In the SVZ and the SGZ, neural stem/progenitor cells (NSPCs) express the glial fibrillary acidic protein (GFAP) and selective...
Preprint
Full-text available
In adult mammals, neural stem cells emerge in three neurogenic regions, the subventricular zone of the lateral ventricle (SVZ), the subgranular zone of the dentate gyrus of the hippocampus (SGZ) and the hypothalamus. In the SVZ and the SGZ, neural stem/progenitor cells (NSPCs) express the glial fibrillary acidic protein (GFAP) and selective ablatio...
Article
Full-text available
Premenopausal bilateral ovariectomy is considered to be one of the risk factors of Alzheimer's disease (AD). However, the underlying mechanisms remain unclear. Here, we aimed to investigate long-term neurological consequences of ovariectomy in a rodent AD model, TG2576 (TG), and wild-type mice (WT) that underwent an ovariectomy or sham-operation, u...
Article
The abrupt loss of ovarian hormones before menopause, induced by oophorectomy, has been associated with accelerated aging, multimorbidity, and Alzheimer’s disease (AD). We investigated the impact of prolonged loss of ovarian hormones on AD progression in a transgenic mouse model of amyloid pathology using in vivo diffusion tensor MRI, resting‐state...
Article
A large proportion of the population suffers from endocrine disruption, e.g., menopausal women, which might result in accelerated aging and a higher risk for developing cognitive disorders. Therefore, it is crucial to fully understand the impact of such disruptions on the brain to identify potential therapeutic strategies. Here, we show using resti...

Citations

... As such, they are ideally positioned to play a role in the rapid integration and transmission of both gonadal and metabolic signals to GnRH neurons, including during minipuberty. Increased nNOS activityand hence NO releaseduring minipuberty, by modulating the transcription, activity and release of GnRH [9], could thus control the secretion of gonadotropins and subsequently, the maturation and function of the neuroendocrine axis [10]. ...
... A recent study published in Science by Manfredi-Lozano and colleagues suggests that the gonadotropin-releasing hormone (GnRH) could potentially restore cognition in patients with Down syndrome (DS). 1 The findings reveal a new molecular link between dementia and the loss of smell, and a promising therapeutic avenue to combat age-related cognitive decline in DS and other neurodegenerative diseases. ...
... In the adult CNS, NSPCs mainly originate from the neuroblast located at the SVZ lining the lateral ventricle, the subgranular zone (SGZ) of the dentate gyrus, and the central canal ependymal stem cells in the spinal cord [26]. Under CNS disease or injury conditions, endogenous NSPCs immediately response, proliferate and migrate towards the damage site. ...
... This confirms the translational value of this preclinical early-stage network hyperconnectivity and even opens the way to potential preventive treatment in genetically disposed AD patients. Kara et al. (2021) performed a longitudinal rsfMRI and DTI study in female tg2576 mice that underwent pre-menopausal bilateral ovariectomy and thus added an additional AD risk factor. They observed a decrease in white matter integrity, and a decrease in rsfMRI FC in ovariectomized vs. sham-operated tg mice. ...
... The expression levels and signaling activity of β-arrestin have been shown to be involved with metabolic aging conditions such as Alzheimer's disease [107,108], Parkinson's' disease [109][110][111], T2DM [112][113][114], osteoporosis [44,46,115] and schizophrenia [116,117]. In a similar vein, research has also demonstrated that the GPCR adaptor GIT2 can play a pivotal role in metabolic aging conditions and disorders, including neurodegenerative diseases [118,119], T2DM [60] osteoporosis [120,121] and psycho-affective disorders [122,123]. In addition to these two major forms of GPCR signaling adaptors, considerable evidence has been generated to demonstrate the role of GRKs, PYK2 and JAK2 in aging-related conditions associated with metabolic dysfunction [2]. ...