V V Malinovskaia's scientific contributions

Publications (12)

Article
The study involved 34 full-term newborn babies born by mothers with chronic nonspecific diseases of the lungs and 10 newborns born by mothers with the physiological course of pregnancy and parturition, the examinations being carried out in the early neonatal period. A lower capacity for production of endogenous and gamma-interferons at delivery and...
Article
The efficacy of therapy with reaferon (recombinant alpha 2-interferon) was studied in children with glomerulonephritis (GN) associated with hepatitis B virus infection as well as its effect on the interferon status (IFN), production of interleukins (IL) 1 and 2 and synthesis of active arachidonic acid (AA) metabolites by the blood cells in the cour...
Article
The authors describe the results of the first experience gained with the use of recombinant alpha 2-interferon in children with acute viral hepatitis B. The drug was administered rectally in combination with antioxidants (tocopherol). The study was carried out by the double blind method with randomization and two control groups (given tocopherol al...
Article
The purpose of the present work was to study the rate of HB viral infection from the standpoint of its pathogenetic importance in children with the nephrotic syndrome (NS). As many as 71 children aged 2 to 15 years with the NS were examined. 23 children with hematuric glomerulonephritic (GN) served as control. HB viral infection markers (HBsAg, ant...
Article
The functional activity of natural killer cells (NKC) in 90 patients with acute viral hepatitis B was studied. As a result, the importance of this characteristic as a criterion of effectiveness of alpha 2-interferon obtained by gene engineering techniques was shown. The study revealed the presence of inverse relationship between the level of the fu...
Article
Content of Met-enkephalin in striatum and of beta-endorphin in rat hypophysis were estimated after administration of ethanol and alpha-interferon into the animals. Ethanol decreased Met-enkephalin content in striatum and of beta-endorphin in hypophysis. Preadministration of alpha-interferon into brain ventricles before ethanol administration led to...
Article
The status of the interferon (IF) system in patients with acute viral hepatitis B (AVHB) was studied, and its importance as a criterion in the evaluation of the effectiveness of interferon therapy was demonstrated. The clinical study of alpha 2-IF was done in 152 patients with AVHB of moderate severity. The preparation was inoculated intramuscularl...
Article
The clinical trials of alpha 2-interferon (alpha 2-IF) (reaferon) in 412 patients with acute viral hepatitis B (AVHB) permitted the establishment of the optimal therapeutic dose and the schedule for the drug use. The drug tolerance appeared satisfactory on the whole. alpha 2-IF was found to have a beneficial effect on the clinical course of VHB. Th...
Article
In clinical trials in 24 healthy volunteers of different doses of reaferon inoculated intramuscularly and intravenously for 3 days a pyrogenic reaction was observed the intensity of which depended upon the dose and route of inoculation. Reaferon exerted a dose-dependent effect on the recipient's interferon system: with large doses the interferon re...
Article
Therapeutic effect of four combinations of antiherpetic chemical preparations--acyclovir (ACV), 9-beta-D-arabinofuranosyladenine (ARA-A) and E-5-(2-bromovinyl)-2'-desoxyuridine (BVDU)--has been studied. Mutual enhancement was observed in all the combinations studied, except for ACV and ARA-A combination, where partial antagonism was observed. ACV +...
Article
The preferential interactions of alpha-interferon (alpha-IFN) with delta and mu opiate receptors were studied. alpha-IFN (specific antiviral activity 2 X 10(3) U/mg protein) was shown to inhibit in the competitive manner 3H-naloxone and 3H-D-ala2, D-leu5-enkephalin (3H-DADL) specific binding to opiate receptor subpopulations. alpha-IFN was much mor...

Citations

... Two different studies reported that vitamin E plasma levels were signifi cantly lower in children with CHB; therefore, combined therapy of interferon-␣ and vitamin E should be used as therapy. 21,22 Another study suggested that an antiviral and immunomodulator preparation named Viferon, produced as rectal suppositories containing recombinant ␣ -2b-interferon and anti-oxidants, should be used in complex therapy of viral chronic hepatitis B and C in children. In this case, it was claimed that higher complete response ratios were achieved. ...
... Pilot production of rIFN-α based on domestically engineered producer Pseudomonas sp. VG-84 and developed by VNII Genetika, IBCH and the Institute of Virology "Vector" was launched in the middle of 80s in Novosibirsk region [20], and already by the end of 80s, domestic rIFN-α was successfully tested in volunteers [21][22][23]. ...
... 14 By sharp contrast, it also was found to increase the levels of cyclic adenosine monophosphate (cAMP) in lymphocytes 15 and to decrease arachidonate metabolism in rat uterine tissue 16 and in blood cells. 17 Thus, the effect of INF-␣ on arachidonate release and metabolism appears to depend on the target cell. To our knowledge no information is available concerning the effect of INF-␣ on arachidonate metabolism in platelets, but if it is similar to its effect on other hematopoietic cells, [15][16][17] the increase in cAMP levels and the decrease in arachidonate metabolism could explain the decrease in platelet response to agonists that was observed in the current study. ...