V. Murugan's research while affiliated with S. J. Thakkar Pharmacy College and other places
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Publications (32)
The present study deals with the preliminary phytochemical study of Indigofera linnaei of family Fabaceae which is commonly known as Birdsville indigo. The Indigofera species has been cited in various literatures for its use in treating rheumatism, arthritis, infl ammation, tumor and liver diseases. The Pharmacognostical study revealed presence of...
The main objective of the study is to investigate the hepatoprotective properties of the methanolic extract of the Mallotus philippensis (Euphorbiaceae) leaves, against ethanol induced liver damage in albino rats. The methanolic extract of Mallotus phillipensis was evaluated for potential hepatoprotective activity in albino rats by ethanol induced...
Peptic ulcer is an ulcer of the mucous membrane lining those parts of the alimentary tract exposed to digestive juices or a necrotic lesion characterized by a crater like erosion of the stomach wall (gastric ulcer) or the duodenum (duodenal ulcer) often associated with painful symptoms. Thiazole derivatives have been reported to possess antiulcer a...
3-Acetylnaphtha-2H-1-pyran-2-one(I) was synthesized from 2-hydroxy-1-naphthaldehyde and acetoacetate in presence of catalytic amount of piperidine.The reaction of 3-Acetylnaphtha-2H-1-pyran-2-one with Bromine in chloroform gave 3-Bromoacetylnaphtha-2H-1-pyran-2-one(II).Compound II was refluxed with thiourea in ethanol and amyl alcohol to get 3-[(3-...
The present study was aimed at evaluating the antioxidant and antiulcer potential of the extracts of Rhodomyrtus tomentosa leaves (RTLE). The leaves and young buds of Rhodomyrtus tomentosa (Family: Myrtaceae) are used in folk medicine for the treatment of abdominal pain, diarrhoea, dysentery and externally for lavage of wounds. Antiulcerogenic acti...
Production of microbial oils by fermentation process using oleaginous organisms is one of the potential alternative sources of lipids. Rhodotorula gracilis, an oleaginous yeast is reported to accumulate 50-60 % of its biomass as lipids. The oil in the form of discrete globules within the cells, is usually extracted using organic solvents after disr...
A series of new chalcones containing pyrimidine heterocyclic ring have been prepared by the condensation of various aldehydes with acetophenone followed by cyclization with thiourea in presence of alcoholic KOH. Chalcones thus prepared were subjected to acetylation with chloroacetyl chloride and the resultant S-chloroacetyl derivatives were subject...
An ethanolic extract containing a combination of the roots of Withania somnifera and leaves of Ocimum sanction was investigated for its nootropic activity in stressed rats. Cold swimming for 5 h induced stress. Learning and memory was assessed using the brightness discrimination apparatus. Stress induced impairment of learning and memory in rats wa...
Production of microbial oil by fermentation process using oleaginous organisms is one of the potential alternative sources of collecting lipids. Rhodotourula gracilis, is one of the oleaginous yeast, explored for their oleaginiecity. The degradation of the cell wall of the yeast is an absolute necessity in order to extract oil using organic solvent...
Withania somnifera (Family Solanaceae) is cultivated in India and North America. The herb has traditionally been used for calming the mind, relieving weakness, nervous exhaustion, arthritis and in helping the body to adapt to physical stress. Ocimum sanctum (Family Lamiaceae) is grown all over India. The present study is carried out to validate sci...
The anti-arthritic activity of stem barks of Alangium salviifolium wang belonging to family Alangiaceae was studied in rats. The barks of Alangium salviifolium wang were collected and dried in shade and subjected for successive extraction with petroleum ether, Ethyl acetate, chloroform, methanol using soxhlet apparatus and distilled water by macera...
A few series of 2-[(bis-(2-chloroethyl)amino)acetamido]-5-substituted-1,3, 4-thiadiazole have been synthesized by chlorination of 2-[(bis-(2-hydroxyethyl) amino)acetamido]-5-substituted-1,3,4-thiadiazole with phosphorous oxychloride and phosphorous pentachloride. The synthesized compounds containing nitrogen mustards were screened for their antican...
Synthesis of six 2- {[bis-(2-chloroethyl)amino]methyl}-6,8-dinitro-1-(4- substituted)-1H-quinazoline-4-one derivatives is reported. The compounds contain nitro groups at positions 6 and 8 of quinazolinone moiety and a phenyl group at position 1. All the six compounds were incorporated with nitrogen mustard moiety. The synthesized compounds were scr...
A survey of Kollimalai hill tracts of Tamil Nadu, India was conducted to record the plants known in the tribal pockets and mentioned in the present paper. Inhabitants utilize a number of medicinal plants for the treatment of various ailments. The present study aims to draw the attention of phytochemists and pharmacologists to the need of further cr...
This present work is an investigation of anticancer activities of the nitrogen mustards possessing quinazolinone, benzimidazole, benzoxazole, and benzothiazole nuclei by the three-dimensional Quantitative Structure Activity paradigm, Comparative Molecular Field Analysis. A total of 39 compounds were modelled in SYBYL 6.7 (Tripos, USA). The molecule...
Simple UV spectrophotometric method has been developed for the estimation of fluconazole from capsule formulation. The proposed method is based on the measurement of light absorption in UV region in methanol. Beer's law is valid in the concentration range of 5-40 mcg/mL The result of capsules assay showed low range of coefficient of variation with...
A new series of 2-{[bis-(2-chloroethyl)amino]-methyl}-1-substituted quinazolinones (V) have been synthesized from 2-{[bis-(2-hydroxyethyl)-amino]- methyl}-1-substituted quinazolinones (IV A-E) with phosphorus trichloride and phosphorus oxychloride. The intermediate 1-substituted phenyl-2-chloromethyl 4-(1H) quinazolinone derivatives (III A-E) and 2...
2-[Bis-(2-hydroxyethyl) amino] acetyl-thio-5-substituted benzimidazote/benzoxazole/benzothiazoles (IVa-h) were treated with phosphorus oxychloride in phosphorus pentachloride to get the title compound (Va-h). All the intermediates and title compounds were characterized by physical, chemical, analytical and spectral data. The biological evaluation o...
The title compounds 2-[2-(bis-(2-chloroethyl) amino)-methyl]-benzothiazoles (III) were synthesized by the reactions of corresponding 2-[2-(bis-(2- hydroxyethyl) amino) methyl] benzothiazole (IIA-D) with phosphorus trichloride and phosphorus oxychloride. The intermediates 2-chloromethyl benzothiazole derivatives (IA-D) and 2-[2-(bis-(2-hydroxyethyl)...
Monobromo anthranilic acid and dichloroanthranilic acid were refluxed with chloroacetyl chloride in dry benzene to form chloroacetyl derivatives, which on cyclization with appropriate arylamine in dry toluene yielded cyclized derivatives (1). Compounds (1) were further refluxed with diethanolamine in pyridine to form 2-[2-bis-(2-hydroxyethyl) amino...
The title compounds (IIIa-e) 4-Chloro-1-[4-(6,8-disubstituted-2- chloromethyl-quinazolin-4-one-3-yl)-phenyl] butane 1,3-dione derivatives were synthesized by the reaction of corresponding 2-chloromethyl-3-(acetophenon-4-yl) -4-(3H) quinazolinone (IIa-e) with ethyl chloroacetate in diispropylether and NaOMe in dry methanol. Compound 2-(N-morpholino...
Anticancer and cytotoxic activities of four title compounds were determined. Among the compounds tested, 6,8-dibromo-2-[2-(styryl)]-4- quinazoline-3-(4-benzhydrazides), (IIIb) and 6,8-dibromo-2-[(phenylbutadienyi) ethylene]-4-quinazoline-3-(4-benzhydrazides) (IIId) showed significant activity. The compounds 6,8-dibromo-2-[2-(thiophene)-ethylene]-4-...
The ethyl acetate, acetone and methanol extracts of Wrightia tinctoria bark showed antinociceptive activity on acetic acid-induced writhing test in mice, their effects being comparable to that of acetylsalicylic acid.
Objective: To perform the androgenic and anti-androgenic activity of the total alkaloid fraction of Alangium salviifolium (Family: Alangiaceae). Materials and methods: The total alkaloid fraction of the methanolic extract of stem bark of Alangium salviifolium was used for the experiment. Immature male albino rats received orally a dose of 10 mg and...
Benzimidazole-2-thioacetylhydrazide (I) on treatment with phenylisothiocyanate yielded thiosemicarbazide (II). Compound (II) on chemoselective cyclization with 4% NaOH, H3PO4, KOH/l(2) respectively gave 4-phenyl-5-[(2-benzimidazolyl) thiomethyl]-3-mercapto-1,2,4 (H)-triazole (III), 2-phenyl amino-5-[(2-benzimidazolyl) thiomethyl-1,3,4-thiadiazole (...
Four new quinazolinone derivatives of 6,8-dibromo-2-methyl-3-[3-mercapto-4-(4-phenyl/substituted phenyl)-4(H)-1,2,4-triazol-5-yl-methyl amino]-quinazolin-4(3H) ones were synthesized and characterized by their spectral and analytical data: All compounds could inhibit the oxytocin-induced rat uterus contractions, however, with a degree of variation....
2-[(2,6,8-Trisubstituted-4-(3H)-oxoqunazolin-3-yl) amino]-5-aryl/heteryl-1,3,4-thiadiazoles (4-12) on reaction with nicotinoyl chloride afforded title compounds viz. 3-{[N-(2,6,8-trisubstituted-4(3H)-oxoquinazolin-3-yl) -N-nicotinyl] amino}-5-aryl/heteryl-1,3,4-thiadiazoles (13-21) in quantitative yields. Nine such title compounds were evaluated fo...
New 2-(4-formyl-3-phenylpyrazolo-1-yl)-amidomethyl-5,6-dichloro-benzothiazole (III) was synthesized by reacting acetophenone-5,6-dichlorobenzothiazol-2-yl-amidomethylhydrazone (II) with Vilsmeier-Haack reagent (DMF/POCI 3). Benzaldehyde/4-nitrobenzaldehyde/4-methoxy benzaldehyde-5,6-dichlorobenzothiazol-2-yl amidomethylhydrazones (IV-VI) were obtai...
Schiffs bases (II) were prepared from respective 2-amino-3-carboxyanilido-4,5,6,7-tetrahydrobenzo [b] thiophene (I) and different arylaldehydes which were treated with diazotized sulfanilamide to give (III). The newly synthesized nine compounds were evaluated for local anesthetic and antimicrobial activities. Many of the compounds showed significan...
Citations
... They are well known as pharmacophores due to their privileged structure. Benzimidazole nuclei have been commonly used as preferred scaffolds for the development of therapeutic molecules of pharmaceutical or biological interest [3], several of the studies show that this type of molecule has antihemic activities [4], anti-HIV [5], anticonvulsant [6], anti-inflammatory [7], antihepatic [8], antineoplastic [9], antiulcer [10], and antioxidants [11]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/738123566837763-1552993780797_Q64/Muthiah-Ramanathan.jpg)
... Những nghiên cứu thành phần hóa học đã xác định nhiều nhóm hợp chất trong các bộ phận của loài Alangium salviifolium như Bảng 1. [6,7,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/314950113792003-1452101366834_Q64/Gowramma-Byran.jpg)
... Further in vivo studies of these compounds did not produce any significant effect on fetal development. Hence, from this it was concluded that the test compound has significant uterine relaxation property and it may be correlated to estrogenic action [236]. The immunological activities of novel g-fluoromethotrexate modified in pteridine ring 320e321 (Fig. 62) was evaluated by in vitro effects on the responses of both Band T cells to lipopolysaccharide, mitogens and concanavalin A, respectively. ...
... The stability of the nucleus, coupled with biological versatility, has inspired numerous researches of the quinazoline scaffold. Currently, quinazoline-4(3H)one and its derivatives are popularly acknowledged as an analgesic [4], antiviral [5], anticancer [6], antibacterial [7], antifungal [8], antimalarial [9] and herbicidal agent [10]. Consequently, the development of new efficient synthetic methods for the construction of structurally diverse quinazolines as potential medicinal agents forms an important area of synthetic and medicinal *Address correspondence to this author at the Department of Pharmaceutical Sciences, Dr. Harisingh Gour Viswavidyalaya, Sagar, MP, India; E-mail: drasmitapatil27@gmail.com ...
... Aqueous extract of seeds of Indian plant 'Cassia fistula' showed antiimplantation activity in female rats (39). The 'bark' of an Indian herb 'Alangium salvifolium' showed antifertility effect in female wistar rats (40). A composite root extract of five plants viz. ...
... In addition, anti-cancer data reveals that 4bromo, 4-chloro and 4-nitro phenyl derivative showed significant decrease in percentage increase in the body weight. Whereas, the rest of two compounds i.e., phenyl and 4-methoxy phenyl derivative exhibited less activity as compared to the control group [96]. Anti-tumor activity of 2-amino-1-(2H)-isoquinolinone, 3-amino-4-(3H)-quinazolinone and 1-substituted-5-amino-1,5-dihydro-4Hpyrazolo-[3,4-d]-pyrimidin-4-one derivative were done by total packed cell volume method in mouse. ...
... Using a 4 mg/kg dose yielded lower activity than piroxicam or diclofenac for the three derivatives. A structural modification was conducted by the introduction of the nicotinyl thiadiazole group at C-3 of 28 to improve the anti-inflammatory activity [58]. Nicotinyl-5-pyridyl thiadiazole of substituted 2-phenylquinazolinone yielded the highest activity, equivalent to standard ibuprofen. ...
... Extraction of compounds from microalgae requires cell disruption as a pretreatment and the extraction yield of carotenoids and antioxidant compounds increase when cells were disrupted using SC-CO 2 rapid depressurization (Uquiche, Antilaf, & Millao, 2016). Another useful application is the extraction of intracellular enzymes, which can be enhanced over those obtained with sonication (Juhász, Székely, Simándi, Szengyel, & Réczey, 2003) and microbial oils produced by oleaginous organisms (Brahmani Priyadarshini, Balaji, & Murugan, 2008); in some cases also for nonfood oils, as in the extraction of lipids from oleaginous yeast using US-assisted SCF extraction, which did not show influence on fatty acid composition . ...
... However, since then no further Med Chem efforts on this scaffold including Structure-Activity Relationship (SAR) studies have been reported. On the other hand, though anticancer / anti-proliferative properties of 2-phenyl-3substituted quinazolin-4-(3H)-ones (B, Fig. 2) have been reported earlier [4][5][6] similar properties of quinazolin-4-(3H)-ones having no substituent at C-2 e.g. (A, Fig. 1) are not known in the literature. ...
... Continuous administration of the extract for seven days significantly decreased the blood sugar (3.53 ± 0.13 mmol/l). Murugan et al. (2002) have carried out androgenic activity of alkaloid fractions extracted from methanol extract of stem bark against Wistar albino rat model. The oral administration of the fraction at 20 mg/kg concentration has significantly increased the weights of testis (468.9 ± 19.26), seminal vesicles (44.0 ± 2.14), ventral prostate (26.0 ± 1.4) and epididymis (84.8 ± 1.65), exhibits its androgenic potentiality. ...
