V Gayathri Devi's research while affiliated with Central Tuber Crops Research Institute and other places
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Publications (7)
This study investigated the inhibitory effects of active component isolated from flavonoid fraction of Vernonia cinerea (FVC), lupeol on selenite induced cataract formation. Previous reports suggest that phytochemicals or natural plant products retard the process of cataractogenesis by scavenging free oxygen radicals. Hence, the present study sough...
Free radical mediated oxidative stress plays a crucial role in the pathogenesis of cataract and the present study was to determine the efficacy of luteolin in preventing selenite induced oxidative stress and cataractogenesis in vitro. Luteolin is a bioactive flavonoid, isolated and characterized from the leaves of Vitex negundo. Lenses were extract...
Oxidative stress has long been recognized as an important mediator in the pathogenesis of cataract and the goal of this study was to determine the efficacy of isorhamnetin-3-glucoside (IR3G) in alleviating the toxicity induced by sodium selenite in in vitro culture condition. IR3G is the bioactive flavonoid isolated and characterized from the leave...
Dregea volubilis is a woody climbing plant commonly found in the hotter parts of India. The leaves are edible and used as a green vegetable, while the plant extract has been used traditionally to treat several diseases including eye ailments. Drevogenin D is a triterpenoid aglycone that has been isolated, purified, and characterized as an active co...
Purpose:
Selenite-induced cataractogenesis is mediated by oxidative stress, accumulation of calcium and activation of lenticular calpains. Calpains are a super family of Ca2+ dependent proteases, which are involved in lens protein proteolysis and insolubilization. Many inhibitors could prevent calpain-induced proteolysis of alpha- and beta-crystal...
Emilia sonchifolia Linn. (DC.) is a traditionally used medicinal plant seen in most tropical and subtropical regions worldwide. Various parts of the plant are used for the treatment of diseases like asthma, intermittent fevers, breast cancer, ophthalmia, nyctalopia etc. We have isolated the flavonoid fraction from E. sonchifolia (whole plant). Fema...
Citations
... In carrageenan induced paw edema mice, VC extract can significantly increase the levels of CAT, SOD, GPx and glutathione-S transferase in blood and liver (Kumar and Kuttan, 2009). Lupeol isolated from VC was found effective in treating cataract formation in Sprague Dawley rats via these antioxidant enzymes (Asha et al., 2016). Enhancing these antioxidant enzymes plays an important role in the protective effect of VC against oxidative stress from gamma radiation in mice (Pratheeshkumar and Kuttan, 2011b). ...
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... Apigenin-7-O-glucoside can protect free radical-induced oxidative damage of pBR322 DNA, bovine serum albumin and erythrocytes [31]. [32]. Quercetin-3-O-glucoside inhibits pancreatic cancer cell migration and has an anti-cancer effect [33]. ...
... Tzvelev, Perilla frutescens (L.) Britt., Nepeta cataria L.), which are often used as traditional Chinese medicines to treat diseases. It has a variety of pharmacological properties, such as anti-bacterial (Laban et al., 2003), anti-inflammatory (Zhu et al., 2011;Xie et al., 2021), anti-oxidation (Rooban et al., 2012;Assunção et al., 2021) and anti-tumour (Attoub et al., 2011;Xie et al., 2012) activities. At present, with the whole world experiencing COVID-19, only luteolin and abyssinone II, out of 43 flavonoids from seven different classes, might act as potential therapeutic candidates for SARS-CoV-2 infection because of their good antiviral activities (Shawan et al., 2021). ...
... The phytochemical screening of C. religiosum Linn. indicates the presence of many constituents, such as alkaloids, glycosides, flavonoids, phenolic, saponins, steroids, coumarins, and leucoanthocyanidins [69,70], although isorhamnetin-3-glucosides (methylated quercetin) and myricetinare have also been isolated [70,71]. It has taken two ...
... Engl., in Ivory Coast, Benin, and Guinea [16]. Methanol plant extract (Kerala, India) None identified In vitro cytotoxicity (L-929 murine lung fibroblast, IC 50 = 15 µg/mL) [28] Aqueous leaf extract (Nsukka, Nigeria) None identified Anti-inflammatory (mouse paw edema assay, ED 50 = 780 mg/kg) [23] Ethanol plant extract (Kerala, India) None identified Inhibition of perchlorate oxidative stress (rat model) [29] Methanol leaf extract (Ibiono, Nigeria) None identified Analgesic (acetic acid writing, formalin hind paw, and hot plate assays, mouse model) [25] CH 3 We report herein our investigation into the collection of L. egregia leaf essential oil and the essential oil from the leaves of E. sonchifolia from southwest Nigeria, the analysis of the essential oil compositions, and antimicrobial screening of the essential oils. This investigation is part of our ongoing research aimed at the characterization of the bioactivity and the compositions of the essential oils from Nigerian medicinal plants for potential exploitation in pharmaceutical applications. ...
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... The fatty and sticky material was removed with petroleum ether (60-80°C) and then extracted with hot methanol in a Soxhlet apparatus. [23] The clear solution in the side tube of the apparatus was the endpoint of extraction with methanol. Finally, methanolic extract was concentrated with a Rota vacuum evaporator. ...
... A selenite-induced cataract is one of the good models of senile nuclear cataract and is very rapidly induced [86]. Degradation of calcium homeostasis increased ROS or free radical generation, calpain (calcium-activated protease) activation, insoluble protein, crystal precipitation, phase change, and cytoskeletal loss are the major causes of selenite-induced cataracts [87]. The eye lens possesses a robust antioxidant system as a defensive mechanism against harmful damage from ROS or free radicals. ...
