Umberto Olcese's research while affiliated with University of Amsterdam and other places

... Pennartz et al. [15] zero in on the visual cortex in rodent models, marshalling an extensive body of evidence in support of the idea that this region is not, in fact, purely visual. Rather, it incorporates signals from motivational, reward and motor systems, in addition to other sensory modalities. ...

... It is particularly well suited to detecting whether cells are driven by optogenetic stimulation in opto-tagging experiments (Dudok et al., 2021;Schneider et al., 2023;Spyropoulos et al., 2023;Szadzinska et al., 2021). It has also been used to detect response onset latencies (Oude Lohuis et al., 2022), and quantify somatosensory and visual stimulus responsiveness (Burnett et al., 2023;Montijn et al., 2023;Qin et al., 2023;Ziegler et al., 2023). ...

... These areas, similarly to V1, are retinotopically organized [19,20] and play a significant role in processing visual information [21][22][23]. However, they have also long been shown to process other sensory modalities [24][25][26][27][28] and be involved in, for example, short-term memory, evidence accumulation and decision making [29][30][31][32][33]. For this reason, § §2 and 3 of this review will focus on V1, an area that, in contrast, is classically considered to be uniquely dedicated to visual processing. ...

... Introduction Individuals usually display a high level of variability in their cognitive abilities and goaldirected behavior 1,2 , often exceeding what would be expected even from genetically identical subjects [3][4][5] . When performing cognitive tasks such as decision making [6][7][8][9] or multisensory integration [10][11][12][13][14][15] , individuals have often been shown to develop separate choice strategies [16][17][18][19][20] . In the case of mice performing decision-making tasks, Pittaras and colleagues observed a broad distribution of behavioral strategies depending on the risk-aversiveness of the animals 17 . ...

... The rodent visual cortex is commonly subdivided into the primary visual cortex (V1) and a set of secondary visual areas generally referred to as higher order visual areas [16][17][18]. These areas, similarly to V1, are retinotopically organized [19,20] and play a significant role in processing visual information [21][22][23]. However, they have also long been shown to process other sensory modalities [24][25][26][27][28] and be involved in, for example, short-term memory, evidence accumulation and decision making [29][30][31][32][33]. ...

... The current treatment options for major depressive disorder are limited, and approximately one-third of the patients do not reach remission, highlighting the need for more research [68]. Until today, alternative testing methods, especially in the field of neurobiology, unfortunately, cannot replace animal experimentation to a full extent [69]. ...

... Wearables are widely used for continuous, community monitoring of heart rate and some have been evaluated in clinical settings although predominantly in younger age groups [17][18][19][20][21][22][23][24][25]. ...

... First, we computed the power in the 500-5000 Hz range to localize layer 5 with the highest MUA spiking power 76 . Second, we showed contrast-reversing checkerboards before each recording session and computed the current source density profile to estimate layer 4 with the earliest current sink, as previously described 77 . Lastly, this was aligned with the depth registered when the silicon probes were lowered from the dura. ...

... McFadden's CEMI theory attributes the solution to the binding problem to the electromagnetic field of the brain, produced by its neural correlates, which stores and binds the memories and experiences of consciousness. This solution is also problematic due to the fact that memories and experiences in the electromagnetic field of the brain, produced by its NCC, are not conscious awareness, i.e., the hard problem of consciousness; nor does it explain the binding problem associated with the latter, i.e., how do memories and information bind to produce the phenomenal subjective experience of consciousness (Pockett,et al. [3,23,(101)(102)(103)(104)(105)(106)(107)(108)(109)(110)(111)(112)(113)(114)(115)). Mc-Fadden's computationalist field theory is one of nine contemporary field theories, dualist field theory, reductionist field theory, realist field theory, globalist field theory, localist field theory, interactionist field theory, epiphenomenalist field theory, and consciousness field theory, which attempts to resolve the binding or combination problem of consciousness. ...

... This behavioral variability reflects different strategies adopted by networks, including choice biases and different levels of speed-accuracy trade-offs [36][37][38] , and can be externally altered via external modulatory currents 19 . Furthermore, we showed that networks tend to choose more accurately and faster in multimodal rather than unimodal trials, highlighting the importance of multisensory integration mechanisms in perception and in strong agreement with experimental evidence and computational frameworks 10,[12][13][14][15][39][40][41] . Adopting a multisensory decision-making task was an optimal choice for this study, due to the task incorporating not only choice but also modality properties. ...