Ulrich Hennecke’s research while affiliated with Vrije Universiteit Brussel and other places

... 201,202 Later, Ye and Zhu 203 investigated the intermolecular hydroamination of N-tosylated 5-amino-1pentene by employing a cobalt catalyst, to produce N-tosylated 2-methylpyrrolidine derivatives. Recently, Hennecke and coworkers 204 reported the hydroamination of N-Nosyl 5-amino-1pentene. Hultzsch et al. 205 synthesized chiral rare-earth-metal Please do not adjust margins Please do not adjust margins (yttrium and lanthanide) complexes containing biphenolate and binaphtholate amido complexes, which were utilized for the hydroamination/cyclization of 5-amino-1-pentene. ...

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’Green’ synthesis of amines from renewable resources? A detailed analysis of case studies using the CHEM21 Green Metrics Toolkit

... Boc and Fmoc are the most common protecting groups used and are removed under acidic and basic conditions respectively [174]. Various resins have been used in SPPS, for example: polystyrene, Merrifield, hydroxymethyl, phenylacetamidomethyl, Wang, Sieber, Rink amide and 4methylbenzhydrylamine resins [174,175]. SPPS based on Fmoc chemistry is the most popular choice of synthesizing peptides nowadays [174]. Since the invention of solid phase synthetic methods by Merrifield in 1963, the number of research focusing on peptide synthesis and their applicability has grown exponentially, finally enabling the routine production of peptides on industrial scale [174,175]. ...

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Nanotechnology in Drug Delivery: Anatomy and Molecular Insight into the Self-Assembly of Peptide-based Hydrogels

... Out of these, lactones are crucial synthetic intermediates in the synthesis of many biologically active natural products. [14][15][16][17] Given the high importance of lactones, numerous methodologies were developed, [18][19][20][21] and amongst them, halolactonization [22][23][24][25][26][27] is widely used to synthesize many natural and biologically active compounds. Due to its high synthetic utility and poor atom economy, there is a great demand for alternative methods, which are mild, efficient, and more atom economical. ...

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Dual Au/Ag Catalyzed Regiospecific Intramolecular Hydroacyloxylation and Hydroalkoxylation of Unactivated Geminal‐Substituted Olefins

... The cyclic dipeptides cyclo (L-phenylalanine-Lproline (2) was derived from the ethyl acetate fraction of endophytic fungus Marchantia polymorpha as major volatile chemical compound, showed cytotoxic and anticancer activity [20]. Previously, Silva et al. [21] synthesized quinoline and its derivatives, moreover quinolone derivatives isolated from pathogen microorganism P. aeruginosa [22]. In our preset work we obtained metabolite 1-methylquinolin-4(1h)-one (3) ethyl acetate extract of most active endophtytic bacteria B. halotolerans XJB-35 for first time. ...

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Secondary metabolites and their biological activities from endophytic bacteria B. halotolerans XJB-35 associated with Vernonia anthelmintica

... This innate stereochemical characteristic is highly reliable and thus indispensable for the stereoselective synthesis of organohalides [3][4][5][6][7][8][9][10][11] . Furthermore, the recent advancements in this field have even reached a remarkably sophisticated level of enantioselectivity control [12][13][14][15][16][17][18][19][20][21][22][23] . On the other hand, the alteration of the diastereochemical course turns out to be more challenging, and only limited examples can be found in the old chemical literature (Fig. 1b) [24][25][26] . ...

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Stereospecific syn-dichlorination of allylic amines enabled by identification of a superior stereo-directing group

... 1.13.11.47) from Pseudomonas putida (Qi et al., 2007) and 2-heptyl-3-hydroxy-4(1H)-quinolone dioxygenase (AqdC) from Mycobacteroides abscessus (Wullich et al., 2019) have been structurally characterized. Although HOD and QDO only share 37 % identity, both act on similar substrates, mainly the name-giving 1H-3-hydroxy-4-oxoquinaldine (Scheme 17) (Steiner et al., 2007). ...

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Harnessing Nature's Catalysts: Advances in Enzymatic Alkene Cleavage

... The chlorinated TPs formed from QSMs very likely lead to reduced QS activity (Syrpas et al., 2014b), reduced bacterial growth (Ritzmann et al., 2019) or/and are potentially harmful (Richardson et al., 2007). For the halogenation of 3-Oxo-C n -AHL, reduced QS activity was observed in Escherichia coli JB523 bioassays (Syrpas et al., 2014b) and a loss of the total QS activity for the final cleavage of the halogenated N-acyl chain was reported (Syrpas et al., 2014a). ...

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Chlorination of Quorum Sensing Molecules: Kinetics and Transformation Pathways

... Later in 2019, the Hennecke group reported an asymmetric dichlorination of unfunctionalized alkenes using C10a as catalyst (Scheme 10). [31] In the following year Yeung group. reported a novel amino-acid-derived phthalazine reagent C10b for the enantioselective fluorocyclizations of prochiral indoles. ...

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Halogen and Chalcogen Activation by Nucleophilic Catalysis

... This innate stereochemical characteristic is highly reliable and thus indispensable for the stereoselective synthesis of organohalides [3][4][5][6][7][8][9][10][11] . Furthermore, the recent advancements in this field have even reached a remarkably sophisticated level of enantioselectivity control [12][13][14][15][16][17][18][19][20][21][22][23] . On the other hand, the alteration of the diastereochemical course turns out to be more challenging, and only limited examples can be found in the old chemical literature (Fig. 1b) [24][25][26] . ...

Reference:

Stereospecific syn-dichlorination of allylic amines enabled by identification of a superior stereo-directing group

... In addition, adamantylidene-adamantane (8) did not retard the reaction (Table 1, entry 9), which is consistent with the fact that the isolated bromiranium ion of 8 was used as a reactive brominating agents. [18] Moreover, as expected in Scheme 2b, trans-cycloocten-5-ol (9) did not possess inhibitory effects (Table 1, entry 10), indicating the negative influence of the generation of HBr. Indeed, the addition of pyridine hydrobromide significantly accelerated the reaction in the presence of 1 a (Table 1, entries 2 and 11). ...

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trans‐Cyclooctenes as Scavengers of Bromine Involved in Catalytic Bromination