Tyler J. VanderWeele's research while affiliated with Harvard University and other places

Publications (601)

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Schools of public health are often situated within universities but not infrequently also function as public health advocacy organizations. Viewpoint diversity on many issues is often limited within schools of public health and does not reflect the diversity one finds in society more generally. It is argued that welcoming, and even seeking out, vie...
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Background: While informal helping has been linked to a reduced risk of mortality, it remains unclear if this association persists across different levels of key social structural moderators. Purpose: To examine whether the longitudinal association between informal helping and all-cause mortality differs by specific social structural moderators...
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It is shown, with two sets of indicators that separately load on two distinct factors, independent of one another conditional on the past, that if it is the case that at least one of the factors causally affects the other, then, in many settings, the process will converge to a factor model in which a single factor will suffice to capture the covari...
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The paper puts forward an analytic definition of “love” that is intended to characterize the use of the word in expressions of the form “He/she loves...” It is proposed that when “love” is used in such contexts, it denotes “a disposition towards either (i) desiring a perceived good or desiring union with it, either as an end itself or with it being...
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The detrimental effects of loneliness and social isolation on health and well-being outcomes are well documented. In response, governments, corporations, and community-based organizations have begun leveraging tools to create interventions and policies aimed at reducing loneliness and social isolation at scale. However, these efforts are frequently...
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Background: Growing evidence suggests that informal helping (unpaid volunteering not coordinated by an organization or institution) is associated with improved health and well-being outcomes. However, studies have not investigated whether changes in informal helping are associated with subsequent health and well-being. Methods: This study evalua...
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This paper presents cross-cultural comparisons of well-being among factory work- ers, as measured by the six well-being domains of happiness and life satisfaction, physical and mental health, meaning and purpose, character and virtue, close social relationships, and financial and material stability. Relative ranks of well-being do- mains across exa...
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When investigators test multiple outcomes or fit different model specifications to the same dataset, as in multiverse analyses, the resulting test statistics may be correlated. We propose new multiple-testing metrics that compare the observed number of hypothesis test rejections ( θ ^ ) at an unpenalized α-level to the distribution of rejections th...
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Frequent working from home (WFH) may stay as a new work norm after the COVID-19 pandemic. Prior observational studies on WFH and work outcomes under non-pandemic circumstances are mostly cross-sectional and often studied employees who worked from home in limited capacity. To provide additional insights that might inform post-pandemic work policies,...
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Objective: Negative life events have the potential to undermine an individual's ability to function and thrive, but less is known about the implications of changes in subjective appraisals of those events for long-term well-being. This research examines how exposure to negative life events and subsequent changes in the perceived impact of those ev...
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Social relationships contribute to well-being across the life course and may be especially vital resources for supporting healthy aging among older adults. This research examined associations between perceptions of social support and social strain from children assessed by older adult parents and 35 indicators of physical, behavioral, and psychosoc...
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Objectives: Examine differences in multidimensional well-being from before (January 2020) to three timepoints during the COVID-19 pandemic (June 2020, January 2021, January 2022). Study design: Repeated cross-sectional design. Methods: Nationally representative cross-sectional cohorts of US adults completed the Secure Flourish Index before (Ja...
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Objective: It is increasingly appreciated that mental health may not just involve a relative absence of mental illness, but the active presence of positive psychological desiderata. However, research attention on mental illness and health has tended to remain siloed and disconnected-proceeding along parallel tracks-with their potential relationshi...
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Recent decades have seen a surge of scientific interest in happiness. However, its theoretical conceptualization is a work in progress. Much of the literature focuses on two main forms: hedonic (encompassing life satisfaction and positive affect) and eudaimonic (encompassing phenomena such as character development and meaning in life). However, thi...
Preprint
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Importance: Forgiveness interventions have been shown in prior randomized trials to reduce depression and anxiety symptoms. Most such interventions require trained therapists, limiting scalability. Objective: To determine whether a brief self-directed forgiveness workbook intervention could alter forgiveness, depression symptoms, and anxiety sympto...
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Psychological well-being, characterized by feelings, cognitions, and strategies that are associated with positive functioning (including hedonic and eudaimonic well-being), has been linked with better physical health and greater longevity. Importantly, psychological well-being can be strengthened with interventions, providing a strategy for improvi...
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Although prior research suggests that residential instability during adolescence can have long-term impacts on health and wellbeing, few studies have identified a robust comparison group and considered a broad set of outcomes. To address these knowledge gaps, we examined the associations between residential instability during adolescence and a wide...
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Background: Spiritual aspects of the human condition may give rise to spiritual pain and suffering, especially in the face of illness or difficult life situations. A growing volume of research documents the effects of religiosity, spirituality, meaning, and purpose on health. In supposedly secular societies, however, spiritual matters are rarely a...
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Psychological climate for caring (PCC) is a psychosocial factor associated with individual work outcomes and employee well-being. Evidence on the impacts of various psychological climates at work is based mostly on self-reported health measures and cross-sectional data. We provide longitudinal evidence on the associations of PCC with subsequent dia...
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Comparing outcomes for individuals remaining married to those for single or divorced individuals might overstate the positive effects of the decision to marry, since marriage carries an inherent risk of divorce and its associated negative outcomes. While a growing literature has examined marital transitions, confounding by past marital history rema...
Preprint
Average treatment effects (ATEs) may be subject to selection bias when they are estimated among only a non-representative subset of the target population. Selection bias can sometimes be eliminated by conditioning on a “sufficient adjustment set” of covariates, even for some forms of missingness not at random (MNAR). Without requiring full specific...
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Research suggests a protective effect of religious service attendance on various health outcomes. However, most research has been done in religious societies, raising the question of whether these associations are also prominent in secular cultures. Here we examine mortality and hospitalisations by religious service attendance among men and women i...
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Prior cross-sectional research suggests that the importance assigned to well-being domains may be associated with actual self-reported well-being in these same domains. However, cross- sectional data cannot discern directionality, leaving an open question as to whether valuing well-being leads to higher actual well-being or the other way around—hig...
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We used prospective data (spanning 8 years) from a national sample of older U.S. adults aged > 50 years (the Health and Retirement Study, N = 13,771) to evaluate potential factors that lead to subsequent religious service attendance. We applied a lagged exposure-wide epidemiologic design and evaluated 60 candidate predictors of regular subsequent r...
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Suffering is an experiential state that every person encounters at one time or another, yet little is known about suffering and its consequences for the health and well-being of nonclinical adult populations. In a pair of longitudinal studies, we used two waves of data from garment factory workers (Study 1 [T1: 2017, T2: 2019]: n = 344) and flight...
Preprint
A response to: Breznau, et al., Observing many researchers using the same data and hypothesis reveals a hidden universe of uncertainty. PNAS 119(44), e2203150119 (2022).
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A wealth of research has suggested the West tends toward individualism and the East toward collectivism. We explored this topic on an unprecedented scale through two new items in the 2020 Gallup World Poll, involving 121,207 participants in 116 countries. The first tapped into orientations toward self-care versus other-care (“Do you think people sh...
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As our society ages and healthcare costs escalate, researchers and policymakers urgently seek potentially modifiable predictors of reduced healthcare utilization. We aimed to determine whether changes in 62 candidate predictors were associated with reduced frequency, and duration, of overnight hospitalizations. We used data from 11,374 participants...
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Our understanding of well-being, and related concepts such as health and flourishing, is shaped by the metaphors through which we think about such ideas. Current dominant metaphors—including a pyramid, ladder, and continuum—all have various issues. As such, this paper offers two other metaphors which can better do justice to the nuanced complexitie...
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We discuss certain critiques of the research literature on flourishing. We fully agree with calls for greater attention to qualitative work, to cultural differences, and to questions of power and justice concerning flourishing. We argue, however, that in spite of notable differences in understandings of flourishing across cultures, there is also a...
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Vitality has been underappreciated and underexplored by academia at large. This oversight is potentially explained by the Western-centric nature of most fields, with vitality having been comparatively neglected in the West relative to elsewhere. One explanation for this lacuna is that vitality is not easily pigeonholed within the ontological catego...
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Factor analysis is often used to assess whether a single univariate latent variable is sufficient to explain most of the covariance among a set of indicators for some underlying construct. When evidence suggests that a single factor is adequate, research often proceeds by using a univariate summary of the indicators in subsequent research. Implicit...
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Background Studies of preterm delivery after COVID-19 are often subject to selection bias and do not distinguish between early vs. late infection in pregnancy, nor between spontaneous vs. medically indicated preterm delivery. This study aimed to estimate the risk of preterm birth (overall, spontaneous, and indicated) after COVID-19 during pregnancy...
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In this commentary, we offer some remarks concerning distinctions that might be drawn between psychological well-being, emotional well-being, well-being more generally, and flourishing. We put forward a flexible map of flourishing to help understand the relative place of these and other terms, and their respective nestings. We discuss some of the c...
Chapter
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Scholarly understanding of happiness continues to advance with every passing year, with new ideas and insights constantly emerging. Some constructs, like life evaluation, have been established for decades, generating extensive research. Cantril’s “ladder” item on life evaluation, for example – the question in the Gallup World Poll upon which this r...
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We examined the associations between a sense of purpose and all-cause mortality by gender and race/ethnicity groups. Data were from the Health and Retirement Study, a nationally representative cohort study of U.S. adults aged >50 (n = 13,159). Sense of purpose was self-reported at baseline (2006/2008), and risk of all-cause mortality was assessed o...
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This paper examines demographic differences in flourishing, defined as “complete well-being” and consisting of six domains: emotional health, physical health, purpose, character strengths, social connectedness, and financial security. Results are based on a random, cross-sectional sample of 2363 survey respondents drawn from employees of a large, n...
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Aims: Prior research documents strong associations between an increased sense of purpose in life and improved health and well-being outcomes. However, less is known about candidate antecedents that lead to more purpose among older adults. Methods: We used data from 13,771 participants in the Health and Retirement Study (HRS) — a diverse, national...
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Background Higher risk of dementia among racial/ethnic minorities compared to White populations in the U.S. has been attributed to life-course exposures to adverse conditions such as lower educational attainment, but most studies have not considered additional disparities in education quality. We sought to determine the extent to which disparities...
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Depression and the subjective experience of suffering are distinct forms of distress, but they are sometimes commingled with one another. Using a cross-sectional sample of flight attendants (n = 4,652), we tested for further empirical evidence distinguishing depression and suffering. Correlations with 15 indices covering several dimensions of well-...
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This survey study assesses well-being among US adults by age group.
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Purpose Excellent character, reflected in adherence to high standards of moral behavior, has been argued to contribute to well-being. The study goes beyond this claim and provides insights into the role of strengths of moral character (SMC) for physical and mental health. Methods This study used longitudinal observational data merged with medic...
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While growing evidence documents strong associations between volunteering and improved health and well-being outcomes, less is known about the health and well-being factors that lead to increased volunteering. Using data from 13,771 participants in the Health and Retirement Study (HRS)-a diverse, longitudinal, and national sample of older adults in...
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Happiness is an increasingly prominent topic of interest across academia. However, relatively little attention has been paid to how it is created, especially not in a multidimensional sense. By ‘created’ we do not mean its influencing factors, for which there is extensive research, but how it actually forms in the person. The work that has been don...
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Importance: Despite growing evidence, the role of spirituality in serious illness and health has not been systematically assessed. Objective: To review evidence concerning spirituality in serious illness and health and to identify implications for patient care and health outcomes. Evidence review: Searches of PubMed, PsycINFO, and Web of Scien...
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A systems perspective explains dynamics of human flourishing based on the relations between its constituents. Using cross-sectional data from emerging adults (ages 18–29) in 10 countries (N = 7221), this study explored the interrelatedness among constituents of flourishing – happiness & satisfaction with life, mental & physical health, meaning & pu...
Preprint
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Background: Research suggests a protective effect of religious service attendance on various health outcomes. However, most research has been done in religious societies, raising the question of whether these associations are also prominent in secular cultures. Here we examine mortality and hospitalisations by religious service attendance among men...
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Background: Little research has examined associations between disaster-related home loss and multiple domains of health and well-being, with extended long-term follow-up and comprehensive adjustment for pre-disaster characteristics of survivors. Objectives: We examined the longitudinal associations between disaster-induced home loss and 34 indic...
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In meta‐analyses, it is critical to assess the extent to which publication bias might have compromised the results. Classical methods based on the funnel plot, including Egger's test and Trim‐and‐Fill, have become the de facto default methods to do so, with a large majority of recent meta‐analyses in top medical journals (85%) assessing for publica...
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In longitudinal studies with time-varying exposures and mediators, the mediational g-formula is an important method for the assessment of direct and indirect effects. However, current methodologies based on the mediational g-formula can deal with only one mediator. This limitation makes these methodologies inapplicable to many scenarios. Hence, we...
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The apolipoprotein E allele 4 (APOE-ε4) is established as a major genetic risk factor for cognitive decline and late-onset Alzheimer’s disease. Accumulating evidence has linked ε4 carriership to abnormal structural brain changes across the adult lifespan. To better understand the underlying causal mechanisms, we investigated the extent to which the...
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Objectives: Evidence on social stimuli associated with mental health is based mostly on self-reported health measures. We aimed to examine prospective associations between social connectedness and clinical diagnosis of depression and of anxiety. Methods: Longitudinal observational data merged with health insurance data comprising medical informatio...
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Background: Estimates of effect heterogeneity (i.e. the extent to which the causal effect of one exposure varies across strata of a second exposure) can be biased if the exposure-outcome relationship is subject to uncontrolled confounding whose severity differs across strata of the second exposure. Methods: We propose methods, analogous to the E...
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PurposeGrowing evidence documents strong associations between overall life satisfaction and favorable health and well-being outcomes. However, because most previous studies have assessed satisfaction with one’s life as a whole, we know little about whether specific domains of life satisfaction (e.g., satisfaction with family life, income) might be...
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Meta-analyses contribute critically to cumulative science, but they can produce misleading conclusions if their constituent primary studies are biased, for example by unmeasured confounding in nonrandomized studies. We provide practical guidance on how meta-analysts can address confounding and other biases that affect studies’ internal validity, fo...
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During the COVID-19 pandemic, the United Kingdom (UK) government introduced public health safety measures to mitigate the spikes in infection rates. This included stay-at-home orders that prevented people from leaving their homes for work or study, except for urgent medical care or buying essential items. This practice could have both short and lon...
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Background: There is a growing cohort of head and neck cancer (HNC) patients affected by late- and long-term posttreatment side effects. Our study evaluates the relationship between the demographics, clinical characteristics, and posttreatment symptom burden with the subjective sense of flourishing among HNC survivors. Methods: A cross-sectional...
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What is the best way to estimate the size of important effects? Should we aggregate across disparate findings using statistical meta-analysis, or instead run large, multi-laboratory replications (MLR)? A recent paper by Kvarven, Strømland and Johannesson (Kvarven et al. 2020 Nat. Hum. Behav. 4, 423-434. (doi:10.1038/s41562-019-0787-z)) compared eff...
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Background In-person religious service attendance has been linked to favorable health and well-being outcomes. However, little research has examined whether online religious participation improves these outcomes, especially when in-person attendance is suspended. Methods Using longitudinal data of 8951 UK adults, this study prospectively examined...
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The longitudinal interrelationships between domains of human well-being or flourishing remain understudied empirically. While different aspects of flourishing may be sought as their own end, it is also the case that well-being in one domain may influence well-being in other domains. Using longitudinal data form a sample of employees from a large na...
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Introduction Human flourishing is a multidimensional concept characterized by a state of complete wellbeing. However, much of the prior research on wellbeing has principally focused on population averages assessed using a single item of wellbeing. This study examined trends in population averages and inequalities for a multidimensional index of wel...
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Importance: Researchers and policy makers are expanding the focus from risk factors of disease to seek potentially modifiable health factors that enhance people's health and well-being. Understanding if and to what degree aging satisfaction (one's beliefs about their own aging) is associated with a range of health and well-being outcomes aligns wi...
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Background: Having a purpose in life has been linked to improved health and wellbeing; however, it remains unknown whether having "Ikigai"-a related but broader concept in Japan-is also beneficial for various physical and psychosocial outcomes. Methods: Using data from a nationwide longitudinal study of Japanese older adults aged ≥65 years, we e...
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In a recent concept paper (Verbeek et al., 2021), the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) Working Group provides a preliminary proposal to improve its existing guidelines for assessing sensitivity to uncontrolled confounding in meta-analyses of nonrandomized studies. The new proposal centers on reporting the E...
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The Global Flourishing Study (GFS) will involve data collection for some 240,000 participants, from twenty-two geographically and culturally diverse countries, with annual data collection on the same individuals for five years. The survey includes questions on well-being, along with demographic, social, economic, political, religious, personality,...
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COVID-19 has infected millions of people and upended the lives of most humans on the planet. Researchers from across the psychological sciences have sought to document and investigate the impact of COVID-19 in myriad ways, causing an explosion of research that is broad in scope, varied in methods, and challenging to consolidate. Because policy and...
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Growing evidence documents strong associations between overall life satisfaction and favorable health and well-being outcomes. However, because most previous studies have assessed satisfaction with one’s life as a whole, we know little about whether specific domains of life satisfaction (e.g., satisfaction with income) might be driving better healt...
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Objective: To describe the bias assessment practice in recently published systematic reviews of mediation studies and to evaluate the quality of different bias assessment tools for mediation analysis proposed in the literature. Method: We conducted an overview of systematic reviews by searching MEDLINE (OvidSP), PsycINFO (OvidSP), Cochrane Datab...
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The COVID-19 pandemic and its sequelae have had significant consequences for many people around the world, precipitating loss of resources in various domains. To date, few studies have reported on how resource loss during the public health crisis has contributed to subjective experiences of suffering, especially among vulnerable populations. Using...
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While past empirical studies have explored associations between types of primary and secondary schools and student academic achievement, outcomes beyond academic performance remain less well-understood. Using longitudinal data from a cohort of children (N = 12,288, mean age = 14.56 years) of nurses, this study examined associations between the type...
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The association between religion, spirituality, and body weight is controversial, given the methodological limitations of existing studies. Using the Nurses’ Health Study II cohort, follow-up occurred from 2001 to 2015, with up to 35,547 participants assessed for the religious or spiritual coping and religious service attendance analyses. Cox regre...
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Mendelian randomisation (MR) studies allow a better understanding of the causal effects of modifiable exposures on health outcomes, but the published evidence is often hampered by inadequate reporting. Reporting guidelines help authors effectively communicate all critical information about what was done and what was found. STROBE-MR (strengthening...
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Importance Mendelian randomization (MR) studies use genetic variation associated with modifiable exposures to assess their possible causal relationship with outcomes and aim to reduce potential bias from confounding and reverse causation. Objective To develop the STROBE-MR Statement as a stand-alone extension to the STROBE (Strengthening the Repor...
Preprint
In a recent concept paper (Verbeek et al., 2021), the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) Working Group provides a preliminary proposal to improve its existing guidelines for assessing sensitivity to uncontrolled confounding in meta-analyses of nonrandomized studies. The new proposal centers on reporting the E...
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Psychosocial constructs can only be assessed indirectly, and measures are typically formed by a combination of indicators that are thought to relate to the construct. Reflective and formative measurement models offer different conceptualizations of the relation between the indicators and what is sometimes conceived of as a univariate latent variabl...
Chapter
This book explores the implications for psychiatric practice of virtues shown to foster self-control, benevolence, intelligence, and positivity, roughly corresponding to the four cardinal virtues of Plato and Aquinas. Chapter authors highlight the psychotherapeutic relevance of virtues of self-control (accountability, humility, and equanimity), ben...