Tung X Nguyen's scientific contributions
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Publications (13)
In vivo proof-of-concept of a novel HBV cure strategy using a unique, proprietary vector construct expressing a non-functional, non-coding (nc)RNA (HBV Hijack RNA)
BACKGROUND Glioblastoma (GBM) is a highly aggressive brain tumor with poor survival outcomes. While conventional treatment strategies such as surgery, radiation, and chemotherapy can extend survival, the prognosis for GBM patients after 2 years remains low. One-year progression-free survival (PFS) and complete response (CR) with recurrent GBM is ex...
Hijacking coronavirus machinery to induce infected cell-specific killing.
We evaluated the SARS-CoV-2-specific antiviral activities of gamma-delta T cells isolated from COVID-19 convalescent individuals
Hijacking Influenza polymerase as a potential pan-influenza treatment
We utilize the virus and cellular machinery to kill the infected cells as a potential cure.
Overexpression of ALDH1 provided chemoprotection to CD34+ cell line and human stem/progenitor cells when exposed to low dose cyclophosphamide
Increased expression GCL modifier subunit alone confers substantial chemoprotection against busulfan
ALDH1 overexpression promotes increased engraftment of HSPCs in vivo when combined with low dose cyclophosphamide chemoselection.
A novel approach for a potential cure for chronic HBV
Citations
... We found three case rapports showing presence of the HCMV in glioblastomas [107][108][109]. Three articles [18,110,111] were relevant for the treatment of the HCMV in glioblastoma patients, but none of them presented results of the HCMV detection in samples from patients. ...
... Other approaches employed to enrich gene modified stem cells in the mice include over-expression of the aldehyde dehydrogenase-1 or the mutant drug resistant Methylguanine methyltransferse in HSPCs using lentiviral vectors which provide cellular resistance against cytotoxic agents such as cyclophosphamide and temozolomide. By using this approach they observed a significant increase in the number of gene modified cells in the mice and non-human primate models [35,36]. ...
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