Tudor Sturzoiu’s research while affiliated with Rutgers, The State University of New Jersey and other places

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Publications (2)


Figure 2. SKF82958-induced expression of c-Fos immunoreactivity in the prelimbic cortex of animals that have been characterized for their GCAs. ( Left ) Schematic illustration of the regions of interest (marked by an arrow) for the prelimbic cortex ( center arrow), agranular insular cortex (in a cross-section taken 5.9 mm rostral to the interaural line, left arrow), and the dorsomedial striatum (located 4.48 mm rostral to the interaural line, right arrow). Coordinates conform to Franklin and Paxinos (1997). ( Right ) Marked differences in the expression of c-Fos immunoreactivity were detected in the prelimbic cortex 60 min after SKF82958 administration between animals of high GCAs ( A ) when compared to animals of low GCAs ( C ). No measurable difference was observed between animals of high GCAs ( B ) and low GCAs ( D ) when administered saline. No c-Fos immunoreactivity was observed in a positive control ( E ). 
Dopamine D1 sensitivity in the prefrontal cortex predicts general cognitive abilities and is modulated by working memory training
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October 2013

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47 Citations

Learning & memory (Cold Spring Harbor, N.Y.)

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A common source of variance (i.e., "general intelligence") underlies an individual's performance across diverse tests of cognitive ability, and evidence indicates that the processing efficacy of working memory may serve as one such source of common variance. One component of working memory, selective attention, has been reported to co-vary with general intelligence, and dopamine D1 signaling in prefrontal cortex can modulate attentional abilities. Based on their aggregate performance across five diverse tests of learning, here we characterized the general cognitive ability (GCA) of CD-1 outbred mice. In response to a D1 agonist (SKF82958, 1 mg/kg), we then assessed the relationship between GCA and activation of D1 receptor (D1R)-containing neurons in the prelimbic region of the medial prefrontal cortex, the agranular insular cortex, and the dorsomedial striatum. Increased activation of D1R-containing neurons in the prelimbic cortex (but not the agranular insular cortex or dorsomedial striatum) was observed in animals of high GCA relative to those of low GCA (quantified by c-Fos activation in response to the D1 agonist). However, a Western blot analysis revealed no differences in the density of D1Rs in the prelimbic cortex between animals of high and low GCA. Last, it was observed that working memory training promoted an increase in animals' GCA and enhanced D1R-mediated neuronal activation in the prelimbic cortex. These results suggest that the sensitivity (but not density) of D1Rs in the prelimbic cortex may both regulate GCA and be a target for working memory training.

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Citations (2)


... Here, we found that SKF-38393 application potentiated the EPSCs in neurons from control and CPZtreated mice. Moreover, several studies showed that D1R-like agonists stimulate c-Fos reactivity in the mPFC [69][70][71] and other brain areas expressing D1R, such as the hypothalamus [51,72]. In this work, we demonstrated that CPZ pretreatment impairs the SKF-38393-induced transcriptional activity. ...

Reference:

Chlorpromazine, an Inverse Agonist of D1R‑Like, Diferentially Targets Voltage‑Gated Calcium Channel (CaV) Subtypes in mPFC Neurons
Dopamine D1 sensitivity in the prefrontal cortex predicts general cognitive abilities and is modulated by working memory training

Learning & memory (Cold Spring Harbor, N.Y.)

... Our findings indicate a significant downregulation in the expression of PSD95 and SYN in the hippocampus of mice with diet-induced insulin resistance. Extensive literature supports the beneficial effects of exercise on insulin resistance [32][33][34], hippocampal neuronal synaptic plasticity [35], and cognitive impairments [36][37][38]. Although there is substantial evidence for the positive effects of aerobic exercise on cognitive functions [39][40][41], research on the impacts of resistance training on cognitive functions is less prevalent. ...

Voluntary aerobic exercise increases the cognitive enhancing effects of working memory training
  • Citing Article
  • September 2013

Behavioural Brain Research