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July 2022
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4 Reads
Neuroinflamación mediada por los astrocitos en el envejecimiento y la neurodegeneración a través del factor nuclear kβ y el receptor de hidrocarburos de arilo Astrocyte-mediated neuroinflammation in aging and neurodegeneration via nuclear factor kβ and the aryl hydrocarbon receptor
July 2022
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1 Read
July 2022
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3 Reads
System (CNS). It is known that, with advancing age, astrocytes promote chronic neuroinflammation that favors loss of homeostasis and predisposes to neuronal death. These glial cells can respond to inflammatory stimuli through signaling cascades involving two essential transcription factors, Nuclear Factor kβ (NFkβ) and Aryl Hydrocarbon Receptor (AHR). NFkβ is rapidly inducible; it has a significant role in the induction of proinflammatory genes such as cytokines and chemokines. The AHR belongs to a family of receptors linked to vascularization, metabolism, and protection from the toxic effects caused by halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons; it is associated with the systemic inflammatory response and has been described as a negative regulator of NFkβ -mediated inflammation. Knowing the molecular mechanisms involved in astrocytes' inflammatory response helps to understand better the aging process and neurodegeneration, as well as the search for inflammatory mediators as therapeutic targets for associated diseases.
