Tomasz Baron’s research while affiliated with Uppsala University and other places

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Publications (1)

Flow chart of the inclusion process. The SUDDY cohort contained 78 sudden cardiac death (SCD) victims in Sweden with congenital heart disease (CHD) between the years 2000 and 2010. Death certificates, autopsy and forensic reports of these individuals had been collected within the scope of that study. Finally, 39 participants from the SUDDY cohort with available autopsy reports and confirmed CHD and SCD diagnoses were included in this study. The study individuals were later divided according to being registered or not in the national quality register for CHD, the SWEDCON register.
The underlying pathologies, according to the autopsy protocols divided into seven main groups: ventricular septal defect (VSD) (n = 3), VSD with other pathology (n = 7), atrial septal defects (ASD) (n = 2), aortic stenosis (n = 2), aortic stenosis with other pathology (n = 3), mitral valve pathology (n = 6) and moderate to severe lesions, including coronary anomalies (n = 16).
The distribution of age at death, overall and for those registered in SWEDCON and not registered, respectively. The horizontal lines within each box represent the median, the dotted line represents the mean, and the upper and lower edges of the box represent the first and third quartiles. The whiskers extend to 1.5 times the interquartile range.
Autopsy results and factors associated with sudden cardiac death in young individuals with congenital heart disease – a nationwide study
  • Article
  • Full-text available

March 2025

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16 Reads

Emma Galos

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Tomasz Baron

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Objectives Sudden cardiac death (SCD) is a leading cause of mortality among individuals with congenital heart disease (CHD), and risk stratification remains challenging. This study aimed to describe the underlying structural cardiac abnormalities in a national cohort of SCD victims with CHD, their socioeconomic status, and interactions with the healthcare system before death. Methods The Swedish study of Sudden Cardiac Death in the Young, 2000–2010, included SCD victims under 36 years, along with population-based controls and their parents. Of 903 SCD victims, 39 with autopsy-defined CHD were included in this study, together with 195 controls. Information on socioeconomic variables and healthcare contacts was gathered from Swedish national registers. Results The median age for SCD was 24 years, and 64% were male. The CHD was undiagnosed before death in 31% of the cases, of whom 8 had coronary anomalies. Moderate to complex CHD was observed in 41%. Structural abnormalities of the ventricles were prevalent, with left ventricular hypertrophy present in 56% and fibrosis in 64%. The cases had a higher frequency of hospital admissions within 6 months before SCD compared to controls (OR 14.1,95% CI 3.80–52.44), p < 0.001. No socioeconomic differences were observed. Conclusions This study identified a broad spectrum of underlying anatomical defects, with ventricular structural abnormalities being a common autopsy finding. The majority of cases had moderate to severe lesions. An increased frequency of healthcare contacts prior to death was noted, which may be a variable needing more attention as a predictor for a higher risk of SCD.

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