Tina Tylek's research while affiliated with Drexel University and other places

... Interestingly, imine-based COFs are negatively charged associated with them [8,9], and thus can be excellent materials for adsorbing positively charged small molecule metabolites, which are difficult to adsorb and deliver using traditional crystalline or amorphous polymeric matrices [10][11][12]. In fact, positively charged small molecule metabolites such as Kynurenic acid (KyH), spermine, spermidine among others can directly modulate immune cell responses toward anti-inflammatory state [13][14][15][16][17]. However, it is not understood which metabolites induce both upregulation of anti-inflammatory T cells and down-regulation of pro-inflammatory T cells, which is essential for generating an effective anti-inflammatory response [11,12,18]. ...

... Exciting advances in nanotechnology-based drug delivery systems have been utilized as a delivery vehicle for topical based therapies. These include multiple matrix-based delivery systems such as electro-spun collagen or hydrogel-based delivery systems that may facilitate sustained topical delivery of CALR at the wound site and protects its activity from the high protease activity present in chronic wounds (171)(172)(173)(174)(175). Although Frontiers in Medicine 08 frontiersin.org ...

... This is because such bioresorbable ceramics combine a range of biomimetic factors, including high surface roughness, mechanical stiffness, and chemical makeup, that upregulate the osteogenic cellular activity [34][35][36][37][38]. For example, CaP-based bioceramics, can degrade in physiological conditions via dissolution and osteoclastic resorption (analogous to native bone) and regulate immune response [39], which in-turn support formation of new bone and enhanced rehabilitation of the damaged tissue [40][41][42]. ...

... Additionally, interactions between cells and biomaterials are also important. The physical, chemical, biological and mechanical cues of these materials have considerable effects on cell behaviors [5][6][7]. In this context, manipulating the behavior and fate of cells by altering the material properties is an attractive and promising approach for achieving or improving the functions of such materials. ...

... where this system provided great immunomodulatory effects by upregulating the prohealing gene of M2 macrophage (CD206) and markedly reducing the pro-inflammatory gene (IL-1β and IL-8) expression [50]. Macrophage-mannose receptor CD206 was characterized as a negative-prognostic biomarker for many malignancies where this biomarker improves the overall survival (OS) of the patients [51][52][53]. ...

... On the other hand, macrophages were polarized to the M2 phenotype, and chronic inflammation was not observed within the defects in the BPHS0 and BPHS30 groups. The biocompatible and 3D porous scaffold structure induced macrophage polarization toward the M2 phenotype; these results were in good agreement with those of previous studies evaluating macrophage phenotypes 45,55,56 . It was speculated that the interconnected porous structure with Fig. 7 In vivo macrophage polarization assessment (n = 3). ...

... HPLs also appear to be useful for xeno-free expansion of immune cells like macrophages [196], dendritic cells (DCs) [197], T-lymphocytes, and chimeric antigen receptor (CAR)-T cells [196,198]. HPL-expanded DCs exhibit good viability, a normal morphology, a satisfactory endocytic capacity, normal phenotypes, and good functional plasticity [197]. ...

... Depending on their size, EVs can be divided into exosomes (40 -100 nm) and microvesicles (100 -1000 nm) and can deliver pro-peptides, cytosolic proteins, microRNAs, mRNAs, and even organelles from one cell to the other [126,127]. For instance, the transfer of mitochondria between different cell types, including macrophages and MSCs, has been proven to occur via EVs [128,129]. Thereby, mitochondria transfer from MSCs has been related to the increase of ATP levels and the enhancement of phagocytic activity of macrophages [130]. Additionally, mitochondria and other cell materials like vesicles, organelles, and signaling molecules can be transferred via direct contact through tunneling nanotubes (TNTs) [123]. ...