Timothy M. Wright's research while affiliated with Hospital for Special Surgery and other places
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Publications (309)
Aims:
When performing revision total hip arthroplasty using diaphyseal-engaging titanium tapered stems (TTS), the recommended 3 to 4 cm of stem-cortical diaphyseal contact may not be available. In challenging cases such as these with only 2 cm of contact, can sufficient axial stability be achieved and what is the benefit of a prophylactic cable? T...
Aims:
Mid-level constraint designs for total knee arthroplasty (TKA) are intended to reduce coronal plane laxity. Our aims were to compare kinematics and ligament forces of the Zimmer Biomet Persona posterior-stabilized (PS) and mid-level designs in the coronal, sagittal, and axial planes under loads simulating clinical exams of the knee in a cada...
Background:
Modular dual mobility (MDM) acetabular component use is rising in total hip arthroplasty. However, concern of mechanically-assisted crevice corrosion (MACC) at the shell-liner interface remains. We investigated shell-liner corrosion using retrieval analyses and corrosion chamber testing.
Methods:
We analyzed fretting and corrosion on...
Introduction:
Dual mobility (DM) liners were introduced to reduce instability in total hip arthroplasty. They were found to allow for motion predominantly at the femoral head and the inner bearing of the acetabular liner; however, little is known if this motion is sufficient to alter polyethylene material characteristics. We assessed crosslink (XL...
Introduction:
Fractures of the polyethylene post are a rare but known complication after posterior-stabilized (PS) total knee arthroplasty (TKA). We evaluated the polyethylene and patient characteristics for 33 primary PS polyethylene components that were revised with fractured posts.
Methods:
We identified 33 PS inserts revised between 2015 and...
Background:
Knee instability is a leading cause of dissatisfaction following total knee arthroplasty (TKA). Instability can involve abnormal laxity in multiple directions including varus-valgus (VV) angulation, anterior-posterior (AP) translation, and internal-external rotation (IER). No existing arthrometer objectively quantifies knee laxity in a...
Introduction
The tibial component in total knee arthroplasty (TKA) is often chosen to maximize coverage of the tibial cut, which can result in excessive internal rotation of the component. Optimal rotational alignment may require a smaller baseplate with suboptimal coverage that could threaten fixation. We asked: does undersizing the tibial compone...
Background:
Dissatisfaction occurs in nearly 20% of patients after total knee arthroplasty (TKA); however, there remains only limited understanding of the biologic mechanisms that may contribute to suboptimal postoperative outcomes requiring revision surgery. Expansion of effector T and B cells, could promote an abnormal healing response via local...
BACKGROUND CONTEXT
Alignment of the cervical spine likely has significant effects on the clinical longevity of the subaxial motion segments. The biomechanical effects of changes in alignment on the cervical spine remain to be understood. Single-level ACDF is a commonly performed procedure and cervical alignment may influence motion transfer to adja...
Objective
Clinical evidence suggests that abnormal mechanical forces play a major role in the initiation and progression of osteoarthritis (OA). However, few studies have examined the mechanical environment that leads to disease. Thus, using a mouse tibial loading model, we quantified the cartilage contact stresses and examined the effects of alter...
A subset of patients undergoing total knee arthroplasty (TKA) for knee osteoarthritis develop debilitating knee stiffness (reduced range of motion) for poorly understood reasons. Dysregulated inflammatory and immune responses to surgery correlate with reduced surgical outcomes, but the dysregulated gene signatures in patients with stiffness after T...
Background:
In TKA, soft tissue balancing is assessed through manual intraoperative trialing. This assessment is a physical examination via manually applied forces at the ankle, generating varus and valgus moments at the knee while the surgeon visualizes the lateral and medial gaps at the joint line. Based on this examination, important surgical d...
Background
While component offset can affect impingement after total hip arthroplasty (THA), the exact impact is unclear. Evaluation of offset on an anterior-posterior pelvic radiograph is different than evaluation in functional positions of impingement, namely flexion/internal rotation and extension/external rotation. We quantified the effect of a...
Background
A uniquely designed, non-heat treated moderately cross-linked acetabular polyethylene liner used in total hip arthroplasty (THA) demonstrated excessive wear during routine follow-up, prompting an evaluation of the linear wear rate.
Methods
All THAs were performed by the senior author. The study group included 38 THAs using the uniquely...
Background
Mobile bearing designs are intended to reduce wear, but mixed results were reported from retrieval analyses. Postmortem evaluation (PM) provides the opportunity to assess polyethylene damage in successful implants. We compared damage patterns, MRI presentation, and histology between mobile bearing and fixed tibial inserts retrieved postm...
Background
Wear and corrosion at the junctions of modular implants are increasingly recognized issues in the design of hip and knee arthroplasty prostheses, yet less is known about their significance in shoulder arthroplasty.
Methods
A query of paired total shoulder implant specimens (e.g., humeral head and stem components from the same patient) w...
Background
Surgeons may resect additional distal femur during primary posterior stabilized (PS) total knee arthroplasty (TKA) to correct a flexion contracture. However, the resultant joint line elevation (JLE) increases midflexion laxity. We determined whether a mid-level constraint (MLC) insert reduced mid-flexion laxity after JLE.
Methods
Six co...
Background
Patients with TKA stiffness are commonly presumed to have arthrofibrosis though no specific test exists. In patients undergoing revision TKA, we asked: (1) Do patients who are revised for stiffness display a synovial reaction on MRI that is different than patients revised for other reasons? (2) Do these patients have a different magnitud...
Background
Cementless total knee arthroplasty is gaining interest as total knee arthroplasty patients become younger, more active, and interested in long-term biologic fixation. New porous coatings have altered mechanical properties to improve bone osseointegration, although limited data exist on this topic. We measured the bone ongrowth on retriev...
Background
Aseptic loosening from implant-associated osteolysis in reverse shoulder arthroplasty (RSA) may contribute to premature implant failure. While articular side polyethylene (PE) damage has been well-documented in the literature, no studies to date have investigated backside wear in RSA. The aims of this investigation were to: (1) document...
Despite growing evidence supporting the evaluation, classification, and treatment of acetabular bone loss in revision hip replacement, advancements have not been systematically incorporated into a single document, and therefore, a comprehensive review of the treatment of severe acetabular bone loss is needed. The Stavros Niarchos Foundation Complex...
Background:
Satisfactory management of bone defects is important to achieve an adequate reconstruction in revision TKA. Metaphyseal cones to address such defects in the proximal tibia are increasingly being used; however, the biomechanical superiority of cones over traditional techniques like fully cementing the implant into the defect has not yet...
Component alignment in total knee arthroplasty is a determining factor for implant longevity. Mechanical alignment, which provides balanced load transfer, is the most common alignment strategy. However, a retrospective review found that varus alignment, which could lead to unbalanced loading, can happen in up to 18% of tibial baseplates. This may b...
Aims
Dual mobility implants in total hip arthroplasty are designed to increase the functional head size, thus decreasing the potential for dislocation. Modular dual mobility (MDM) implants incorporate a metal liner (e.g. cobalt-chromium alloy) in a metal shell (e.g. titanium alloy), raising concern for mechanically assisted crevice corrosion at the...
Background
An extended trochanteric osteotomy (ETO) safely addresses femoral component removal during challenging revision total hip arthroplasty. However, no prior study has evaluated whether a difference in axial stability exists between ETO closure performed before (reconstitution) or after (scaffolding) canal preparation and stem impaction. We...
Post‐traumatic osteoarthritis (PTOA) is associated with abnormal and increased subchondral bone remodeling. Inhibiting altered remodeling immediately following joint damage can slow PTOA progression. Clinically, however, inhibiting remodeling when significant joint damage is already present has minimal effects in slowing further disease progression...
Aims:
Surgeons commonly resect additional distal femur during primary total knee arthroplasty (TKA) to correct a flexion contracture, which leads to femoral joint line elevation. There is a paucity of data describing the effect of joint line elevation on mid-flexion stability and knee kinematics. Thus, the goal of this study was to quantify the ef...
Concerns persist that the Optetrak Logic posterior-stabilized (PS) total knee arthroplasty (TKA) femoral component might correlate with early failures due to aseptic loosening. The primary aim of this study was to examine if the use of the Optetrak Logic PS femoral component is associated with early (<5 years) and more extensive aseptic loosening c...
Background
Titanium tapered stems (TTS) achieve fixation in the femoral diaphysis and are commonly used in revision total hip arthroplasty. The initial stability of a TTS is critical, but the minimum contact length needed and impact of implant-specific taper angles on axial stability are unknown. This biomechanical study was performed to better gui...
Introduction
This study examined a cohort of retrieved rotating hinge (RH) total knee arthroplasty implants of four different designs with emphasis on the surface damage observed on the polyethylene components. Our purpose was to determine if differences in polyethylene damage existed among the designs, and if those differences could be explained b...
Preoperative flexion contracture is a risk factor for patients’ dissatisfaction following primary total knee arthroplasty (TKA). Previous studies utilizing navigation technology and cadaveric models attempted to identify surgical techniques to correct knees with flexion contracture and minimize undesirable outcomes such as knee instability. However...
Early periprosthetic fractures after total knee arthroplasty are rare but devastating complications which require revision surgery and lead to poor patient satisfaction. We present 2 siblings who underwent primary total knee arthroplasty on the same day and then both presented 2 weeks after surgery with atraumatic periprosthetic femur fractures. Th...
In total ankle arthroplasty, the interaction at the joint between implant and bone is driven by a complex loading environment. Unfortunately, little is known about the loads at the ankle during daily activities since earlier attempts use two‐ or three‐dimensional models to explore simplified joint mechanics. Our goal was to develop a framework to c...
Finite element (FE) models to evaluate the burden placed on the interaction between total ankle arthroplasty (TAA) implants and the bone often rely on peak axial forces. However, the loading environment of the ankle is complex, and it is unclear whether peak axial forces represent a challenging scenario for the interaction between the implant and t...
Category
Ankle
Introduction/Purpose
Biologic fixation of total joint replacements by bone ingrowth requires minimal bone-implant micromotion [1]. Computational finite element (FE) models used to evaluate the interaction between implant and bone typically only consider simplified loading conditions based on the peak compressive force which occurs n...
Aims:
This combined clinical and in vitro study aimed to determine the incidence of liner malseating in modular dual mobility (MDM) constructs in primary total hip arthroplasties (THAs) from a large volume arthroplasty centre, and determine whether malseating increases the potential for fretting and corrosion at the modular metal interface in mals...
OBJECTIVES/GOALS: To quantify clinical exam in total knee arthroplasty by answering the following questions: (1) What are the magnitudes of forces applied by surgeons during the varus-valgus exam? (2) Is the choice of tibial insert thickness related to the magnitude of the applied forces? (3) How accurately does a surgeon estimate the gaps in the v...
Measured resection is a common technique for obtaining symmetric flexion and extension gaps in posterior‐stabilized total knee arthroplasty (TKA). A known limitation of measured resection, however, is its reliance on osseous landmarks to guide bone resection and component alignment while ignoring the geometry of the surrounding soft tissues such as...
Background
We evaluated bone volume fraction (BVF) in retrieved acetabular shells with two types of porous coatings: 1) Titanium fiber mesh (HG) components and 2) Tantalum metal coatings (TM) components.
Methods
8 HG shells were matched to 8 TM shells for patient age, BMI, and sex. The mean age at index surgery was 69 (51-82) years, mean BMI was 2...
Biologic failures of hip arthroplasty have emerged as an increasing threat to the longevity of the prosthesis. While wear of modern-day bearings has been greatly reduced with the advent of cross-linked polyethylene, local reaction to metal particles either from the bearing itself or to any of the modular tapers appears to be on the rise. Monitoring...
Background:
We investigated the effect of taper design, head material, and manufacturer on simulated mechanically assisted crevice corrosion (MACC).
Methods:
Six pristine C-taper stems coupled with alumina-zirconia or cobalt-chromium (CoCr) heads were tested in a mechanical/electrochemical setup to measure average fretting currents and fretting...
We present a rare case of a patient who presented with complete and rapid wear-through of a ceramic femoral head through a polyethylene liner and titanium acetabular cup. In addition, this patient exhibited significantly elevated serum titanium ion levels, which may serve as a marker of severe metallosis in cases where the preoperative plain radiog...
Background:
To avoid the morbidity of removing well-fixed implants during revision surgery, the off-label practice of mixing femoral heads with dual mobility (DM) polyethylene liners from different manufacturers is commonly performed. The resistance to intraprosthetic dislocation, when the inner prosthetic head disengages from the polyethylene bea...
Background:
Zirconia-toughened alumina ceramic was introduced as a femoral head material for total hip arthroplasty. The material combines the stability of alumina with the toughness of zirconia. Despite inherent benefits for bearing surfaces, concern exists in the medical field that phase transformation of the zirconia grains could worsen wear re...
Compliant self-adjusting compression implants are a novel approach to increase the durability of megaprosthesis fixation. However, there is no report of current implant designs that documents the bone-prosthetic interface of this implant. A well-fixed compliant, self-adjusting distal femoral replacement was retrieved from a patient undergoing revis...
Introduction:
Unfulfilled expectations, assessed postoperatively, have been consistently associated with dissatisfaction after total knee arthroplasty (TKA). However, identifying these expectations preoperatively has been a challenge. We aimed at identifying specific expectations that are most likely to affect postoperative dissatisfaction.
Metho...
Objective:
Mechanical loading and joint health have a unique relationship in osteoarthritis (OA) onset and progression. Although high load levels adversely affect cartilage health, exercise that involves low to moderate load levels can alleviate OA symptoms. We sought to isolate the beneficial effects of mechanical loading using controlled in vivo...
Background:
The metaphyseal region of the bone has been recognized by its importance to the overall stability of a revision construct. Porous titanium metaphyseal sleeves to enhance biologic fixation can be used to manage bone loss encountered during revision total knee arthroplasty. While clinical results for metaphyseal sleeves are encouraging,...
Purpose:
A high-resolution cone-beam CT (CBCT) system for extremity imaging has been developed using a custom complementary metal-oxide-semiconductor (CMOS) x-ray detector. The system has spatial resolution capability beyond that of recently introduced clinical orthopedic CBCT. We evaluate performance of this new scanner in quantifying trabecular...
This is the first report, to our knowledge, of a fracture, unrelated to trunnion corrosion, through the midneck of a well-fixed uncemented cobalt-chromium alloy femoral component that had been implanted via a total hip revision arthroplasty 25 years ago. Three years after a second revision for polyethylene wear, the patient noted an acute onset of...
Purpose
The purpose of this study was to evaluate the thickness of medial and lateral posterior femoral condylar bone resected with five implant systems using posterior referencing jigs set at 3° of external rotation. The hypothesis was that posterior condylar resection thickness on the medial side would be equal to the thickness of the femoral imp...
Background:
Whether anterior referencing (AR) or posterior referencing (PR) produces a more balanced flexion gap in total knee arthroplasty (TKA) using measured resection remains controversial. Our goal was to compare AR and PR in terms of (1) medial and lateral gaps at full extension and 90° of flexion, and (2) maximum medial and lateral collater...
Background:
MRI is predictive of adverse local tissue reactions (ALTRs) after THA but how MRI directly relates to implant surface wear, fretting, and trunnion corrosion at different articulations between implant components remains unclear. MRI generates high-contrast images to display soft tissues around arthroplasty and may provide a surgeon the...
Finite element (FE) models are frequently used to assess mechanical interactions between orthopaedic implants and surrounding bone. However, FE studies are often limited by: the small number of bones that are modeled; the use of normal bones that do not reflect the altered bone density distributions that result from osteoarthritis (OA); and the app...
Background:
Our understanding of fretting and corrosion at head-neck junctions in modular THAs in vivo is based largely on the analysis of retrieved implants removed for various diagnoses. Little is known about the condition of head-neck tapers in well-functioning THAs.
Questions/purposes:
Regarding a cohort of well-functioning autopsy-retrieved...
Background:
Prosthetic impingement is implicated in dislocation after total hip arthroplasty (THA). While use of larger diameter femoral heads reduces the incidence of dislocation, the effect of larger heads upon impingement rate is unknown. We assessed retrieved THA components for evidence of impingement to determine if large femoral heads reduce...
Fracture of a well-ingrown femoral component is a rare and often challenging complication. Modular junctions and sleeve interfaces have been identified as one potential point of weakness with corrosion and fretting being contributing factors to ultimate femoral component fracture. Stem fractures at the sleeve interface were reported occasionally fo...
Constrained acetabular liners have been developed for patients who are at high risk for dislocation or who are undergoing revision surgery for recurrent dislocations. We report on 2 cases of failure of tripolar constrained liners due to severe backside polyethylene wear after dissociation of the outer polyethylene liner without dislocation, a mode...
Background:
Highly crosslinked ultrahigh-molecular-weight polyethylene (XLPE) shows reduced wear in total hip arthroplasty compared to direct compression-molded polyethylene (compPE); however, minimal research evaluating polyethylene damage in XLPE tibial inserts in total knee arthroplasty exists.
Questions/purposes:
We evaluated damage and mate...
Background
In knee arthroplasty with preoperative varus deformity, medial collateral ligament (MCL) release may be needed to achieve balance. Pie-crusting allows for controlled release, but questions remain regarding its ability to obtain predictable results.
We compared 16 vs.18 gauge needle punctures and determined the number of punctures require...
Background
Implant related impingement is likely a major causative factor of total hip arthroplasty (THA) instability. Dual mobility (DM) cups can theoretically improve stability in THA, but impingement rates with DM cups are not well studied. We examined retrieved DM THA liners to determine if less evidence existed of prosthetic impingement betwee...
Background:
Oxidized zirconium (OxZr) femoral heads were introduced in hip arthroplasty to reduce wear of the polyethylene compared with metallic heads and to reduce fracture risk compared with ceramic heads. Severe scratches have been reported on OxZr heads in patients undergoing revision for instability, but whether these scratches contribute to...
Background:
The correct amount of external rotation of the femoral component during TKA is controversial because the resulting changes in biomechanical knee function associated with varying degrees of femoral component rotation are not well understood. We addressed this question using a computational model, which allowed us to isolate the biomecha...
Medial unicompartmental knee arthroplasty (UKA) is an accepted treatment for isolated medial osteoarthritis. However, using an improper thickness for the tibial component may contribute to early failure of the prosthesis or disease progression in the unreplaced lateral compartment. Little is known of the effect of insert thickness on both knee kine...