Thomas Bücher’s research while affiliated with University of Wuppertal and other places

This paper reports investigations led on the combination of the refractive index and morphological dilation to enhance performances towards breast tumour margin delineation during conserving surgeries. The refractive index map of invasive ductal and lobular carcinomas were constructed from an inverse electromagnetic problem. Morphological dilation combined with refractive index thresholding was conducted to classify the tissue regions as malignant or benign. A histology routine was conducted to evaluate the performances of various dilation geometries associated with different thresholds. It was found that the combination of a wide structuring element and high refractive index was improving the correctness of tissue classification in comparison to other configurations or without dilation. The method reports a sensitivity of around 80% and a specificity of 82% for the best case. These results indicate that combining the fundamental optical properties of tissues denoted by their refractive index with morphological dilation may open routes to define supporting procedures during breast-conserving surgeries.

This letter presents a 210–291-GHz $8\times$ multiplier chain in the 0.13- $\mu \text{m}$ SiGe Bipolar CMOS (BiCMOS) technology for the broadband generation of carrier signals, imaging, and spectroscopy. It consists of three cascaded Gilbert-cell doublers with compact input matching networks to generate quadrature collector currents in the switching quad for broadband flat conversion gain. The multiplier chain generates a saturated output power of −7.7 dBm at 244.5 GHz with a 3-dB bandwidth of 81 GHz. It consumes 0.24 W of dc power and occupies 0.86 mm ² of chip area.

Breast Cancer is one of the most frequently diagnosed cancer diseases worldwide, and the most common invasive tumour for women. As with all cancers, early detection plays a major role in reducing the mortality and morbidity rate. Currently, most breast cancers are detected due to clinical symptoms, or by screening mammography. The limitations of these techniques have resulted in research of alternative methods for imaging and detecting breast cancer. Apart from this, it is essential to define precise tumour margins during breast-conserving surgeries to reduce the re-excision rate. This study presents the advances in the development of a silicon-based THz sub-wavelength imager usable in life science applications, especially for tumour margin identification.