Teresa Puig Miquel's research while affiliated with Universitat de Girona and other places

Publications (4)

Article
Full-text available
Three-dimensional printing technologies allow for the fabrication of complex parts with accurate geometry and less production time. When applied to biomedical applications, two different approaches, known as direct or indirect bioprinting, may be performed. The classical way is to print a support structure, the scaffold, and then culture the cells....
Article
Full-text available
The majority of patients develop resistance against suppression of HER2-signaling mediated by trastuzumab in HER2 positive breast cancer (BC). HER2 overexpression activates multiple signaling pathways, including the mitogen-activated protein kinase (MAPK) cascade. MAPK phosphatases (MKPs) are essential regulators of MAPKs and participate in many fa...
Article
Full-text available
Triple-Negative Breast Cancer (TNBC) has poor prognosis and no approved targeted therapy. We previously showed that the enzyme fatty acid synthase (FASN) was largely expressed in a small TNBC patients’ cohort and its inhibition synergized with cetuximab in TNBC preclinical mouse models. Here, we evaluated FASN and EGFR expression in a cohort of TNB...
Conference Paper
Background. The majority of patients develop resistance against suppression of HER2-mediated signaling by trastuzumab in HER2 positive breast cancer (BC). HER2 overexpression activates multiple signaling pathways, including the mitogen-activated protein kinase (MAPK) cascade. MAPK phosphatases (MKPs) are essential regulators of MAPKs and participat...

Citations

... Increased DUSP4 expression in CRC correlates with development of distant metastasis and a poor prognosis (Varela et al. 2020). Up-regulation of DUSP4 in HER2 + breast cancer patients with resistance to the anti-HER2 mAb trastuzumab is significantly associated with a worse overall survival (Menyhart et al. 2017). In contrast, low DUSP4 expression correlates with higher tumor stages, tumor metastasis and a worse overall survival in gastric cancer (Bang et al. 2021). ...
... FASN expression has been reported to be associated with a poor prognosis in several types of tumours (15,16); thus, ADP expression in carcinoma cells might be related and occur via overexpression of FASN. In addition, FASN expression has been reported to correlate with the frequency of lymph node metastasis but is uncorrelated with prognosis in TNBC (17). Although an inverse correlation between FASN and ADP expression has been reported in salivary duct carcinomas (18), the relationship between FASN and ADP in TNBC remains unclear. ...