Tamires dos Santos Vieira's research while affiliated with Universidade Federal do Espírito Santo and other places

... Notably, the same brain region contains a vast range of neuronal types that are classified by morphological, anatomical, and physiological features. [26,27] The function underlying depressive function in mouse model [28][29][30] Response to antidepressants [20,[31][32][33][34] Anxiety-like behaviors [28,29] Cocaine reward-seeking behavior [17] Relations with nicotine addiction in human beings [35,36] Circadian rhythm [22] Sleep regulation and NREM sleep [37] VI Spatial memory reversal and Contextual memory extinction [38] Dendrites localization and Distal dendritic development [24] Relations with schizophrenia patients [21] Schizophrenia-like phenotypes in mice [11] To investigate the function of specific Bdnf promoters, our group (Dr. Bai Lu and colleagues) generated mouse lines, named Bdnf -e1 −/− , e2 −/− , e4 −/− , and e6 −/− mice, in which Bdnf Promoters I, II, IV, and VI were selectively disrupted. ...

... However, there were no methylation differences between the buffy coats of individuals with and without MetS in the CpGs evaluated for the 1F region, even though the expression of these genes is similar in blood and hypothalamus. Although no association studies of MetS with NR3C1 differential methylation were found in the literature, variations in its methylation patterns have been observed for related comorbidities, such as cardiovascular diseases [22], subclinical arteriosclerosis (hypermethylation of the 1F promoter, in a study with monozygotic twins) [66], overweight (hypomethylation of the 1F region, CpGs 40 to 47) [51], unfavorable prognosis for coronary acute syndrome in individuals with depression (hypermethylation of exon 1F) [67], blood pressure (hypermethylation of 1F and 1H promoters associated with lower blood pressure) [68], and a positive association between methylation and glucose levels as well as insulin resistance [69]. Considering the multiple alternative first exons and their variability in tissue-specific expression, and that each of these exons has its own active promoter, DNA methylation and other epigenetic mechanisms should be evaluated in other regions. ...

... The NR3C1 gene is highly expressed in the brain, and its main transcripts are similarly expressed in brain tissues and whole blood [50]. Thus, methylation and gene expression profiles in the buffy coat probably reflect those in the brain, and may also reflect alterations in the HPA axis [51]. In the present study, we investigated NR3C1 polymorphisms, methylation patterns in CpGs mapped to the 1F region, and their expression in buffy coats from MetS subjects and controls of an isolated population. ...

... Thus, all biscuit formulations showed adequate acidity. In a study, Vieira et al. (2015) evaluated the potential of different flours as substitutes for wheat flour in the development of biscuits and found that in the formulation containing the greatest amount of cassava starch, the pH stayed around 7.19 and the acidity was 0.04. This shows evidence that dry products such as flour and starch obtained from cassava roots can increase the pH and reduce the acidity of biscuits. ...