Tamás Ferenci's research while affiliated with Neumann University and other places

Publications (158)

Preprint
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Purpose The purpose of the present study was to find the independent predictors of Fractional Flow Reserve (FFR) measured immediately after percutaneous coronary intervention with drug eluting stent implantation (post-PCI FFR) and investigate if applying vessel-specific post-PCI FFR cut-off values to predict target vessel failure (TVF), a composite...
Article
Background: In the hypertensive population, the peripheral arterial disease (PAD) is considered one of the target organ damages. Ankle-brachial index (ABI) measurement represents the widely accepted clinical method that may objectively detect the presence of PAD. The study aimed to assess how PAD revealed by ABI predicts mortality in patients with...
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Several studies have reported the waning effectiveness of COVID-19 vaccines. This study aims to demonstrate the applicability of the screening method for estimating vaccine effectiveness (VE) in a pandemic. We report VE in Hungary, estimated with the screening method, in 2021, covering a period of Alpha and the Delta variant, including the booster...
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This randomized study aims to compare the left atrial (LA) lesion size, function, and tissue damage following pulmonary vein isolation (PVI) by high-power short-duration (HPSD) radiofrequency (RF) and second-generation cryoballoon (CB2) ablation. We enrolled 40 patients with paroxysmal atrial fibrillation who underwent PVI by HPSD RF (n = 21) or CB...
Article
Background: We evaluate the prognostic value of measuring fractional flow reserve (FFR) after percutaneous coronary intervention (post-PCI FFR) and intravascular imaging in patients undergoing PCI for three-vessel coronary artery disease (CAD) in the FAME 3 trial. Methods: The FAME 3 trial is a multicenter, international, randomized study comparing...
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Background IDegLira is a fixed-ratio combination of insulin degludec and liraglutide with proven efficacy against simpler regimens and non-inferiority against basal-bolus insulin therapy. However, the evaluation of its real-world effectiveness is hindered by technical issues and requires further exploration. Thus we aimed to compare effectiveness o...
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Background Data from primary care regarding the prevalence of symptoms of depression and anxiety, and their effect on glycemic control among people with diabetes is lacking in Hungary. The recently introduced Patient Health Record (PHR) requires family doctors to screen for depressive symptoms. Objectives We aimed to investigate the prevalence of...
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Background Data on how differences in risk-factors, treatments and outcomes differ between sexes in European countries are scarce. We aimed to study sex-related differences regarding baseline characteristics, in-hospital managements, and mortality of ST elevation myocardial infarction (STEMI) patients in different European countries. Methods Patie...
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Background: Appropriate feeding of infants and young children is essential for healthy growth and the prevention of stunting, wasting, and overweight. We aimed to assess the beneficial versus harmful effects of providing fortified complementary foods to children in the complementary feeding period. Methods: In this systematic review and meta-ana...
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Cancer therapy optimization is an issue that can be solved using the control engineering approach. An optimal therapy generation algorithm is presented and tested using a tractable mouse model of breast cancer. The optimized therapeutic protocol is calculated in a closed-loop manner at fixed time instants, twice in a week. The controller consists o...
Article
Összefoglaló. Bevezetés: Szívinfarktust túlélt betegeknél a thrombocytaaggregáció-gátló (TAG-) kezelésnek fontos szerepe van az újabb ischaemiás események megelőzése szempontjából. Célkitűzés: Annak vizsgálata, hogy a kórházi távozás idején a betegek milyen arányban részesültek clopidogrel-, prasugrel- és ticagrelorkezelésben, és az utánkövetés ide...
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Background: Lower limb major amputations represent a substantial public health burden in Hungary, where previous research revealed markedly high rates with significant spatial variations. Therefore, we aimed to assess to what extent healthcare and socio-economic factors in the local environment explain the regional disparity. Patients and methods:...
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Background: Healthy life expectancy (HLE) is becoming an important indicator of population health. While actuarial estimates of HLE are frequently studied, there is scarcity of research on the subjective expectations of people about their HLE. The objective of this study is to compare actuarial and subjective HLE (sHLE) estimates in the ≥50-year-o...
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Objectives Assessment of variations in utilising lower extremity open and endovascular surgery (LEOPEN and LEENDO) across small geographic areas in Hungary from 2013 to 2017. Introduction of a new metric giving a rough estimate of unwarranted clinical variation in revascularisation practice. Design A retrospective analysis. Materials Healthcare a...
Preprint
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Several studies have reported a waning of the effectiveness of COVID-19 vaccines. We report real-life vaccine effectiveness in Hungary, estimated with the screening method, in 2021, i.e., covering the dominance of both the Alpha and the Delta variant, and including the booster roll-out. Hungary is in the unique position to use six different vaccine...
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Background Limited information is available on the effectiveness of the BBIBP-CorV (Sinopharm, Beijing CNBG) vaccine, especially in the elderly, despite the fact that it is approved in more than 50 countries. Methods RBD-specific antibody titres, as a rapidly available and highly predictive surrogate marker, were measured after two doses of the BB...
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A vérnyomáscsökkentő terápiában a családorvosi gyakorlatban megmutatkozó eltérések elemzése érdekében 2543 családorvos bevonásával online kérdőíves felmérést végeztünk különböző karakterisztikájú – esendőség, SBP és CVD tekintetében –, nagyon idős (80 évesnél idősebb) betegek körében. Arra is kerestük a választ, hogy mennyire befolyásolja a kezelés...
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In the era of novel psychoactive substances (NPS), the internet became a relevant source of information and purchase for those who consume psychoactive drugs. Parallelly, a growing body of research aim to utilize web search metrics (most commonly by relying on Google Trends data) in the prediction of substance use-related trends, including epidemio...
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Objective Characterizing blood glucose curves and providing precise patient level risk assessment of hyperglycemia using extreme value statistics and comparing these assessments with traditional indicators of glycemic variability which are not designed to specifically capture the risk of hyperglycemia. Research Design and Methods One year return l...
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Background Alternative methods could be used to enhance the monitoring and forecasting of re-emerging conditions such as pertussis. Here, whether data on the volume of Internet searching on pertussis could complement traditional modeling based solely on reported case numbers was assessed. Methods SARIMA models were fitted to describe reported week...
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Introduction Women receive less evidence-based care than men and have higher mortality after myocardial infarctions than men. But it is not known how the gender difference in risk factors, treatments and outcomes differs between European countries. Purpose In order to investigate the gender differences in European countries with different economic...
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Prognosis of supraventricular tachycardias in neonates and infants is thought to be excellent with rare fatal outcomes. Nevertheless, initial management can be challenging. The aim of this study was to perform a retrospective analysis in neonates/infants with non-pos-toperative supraventricular tachycardias regarding risk factors for clinical outco...
Preprint
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Background: Limited information is available on the effectiveness of the BBIBP-CorV (Sinopharm, Beijing CNBG) vaccine, especially in the elderly, despite the fact that it is approved in more than 50 countries. Methods: Virus neutralizing antibody titres, as a rapidly available but highly predictive surrogate marker, were measured after two doses of...
Article
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The burden of an epidemic is often characterized by death counts, but this can be misleading as it fails to acknowledge the age of the deceased patients. Years of life lost is therefore widely used as a more relevant metric, however, such calculations in the context of COVID-19 are all biased upwards: patients dying from COVID-19 are typically mult...
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Aim Out-of-hospital cardiac arrest (OHCA) is a severe complication of myocardial infarction. Literature data on the incidence of OHCA are inconsistent, and population-level data are incomplete. Methods Based on the Hungarian Myocardial Infarction Registry, the incidence of OHCA and its 30-day and 1-year mortality, as well as the significance of fa...
Preprint
Full-text available
The burden of an epidemic is often characterized by death counts, but this can be misleading as it fails to acknowledge the age of the deceased patients. Years of life lost is therefore widely used as a more relevant metric, however, such calculations in the context of COVID-19 are all biased upwards: patients dying from COVID-19 are typically mult...
Article
In a recent systematic review, we investigated the medium‐ and long‐term effects of non‐nutritive sweeteners (NNS) in people with diabetes mellitus. We included randomised controlled trials (RCTs) with a duration of four weeks or more comparing any type of NNS with usual diet, no intervention, placebo, water, a different NNS, or a nutritive sweeten...
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Összefoglaló. Bevezetés: A heveny szívinfarktus gyakoriságának és halálozásának napi és szezonális ingadozása fontos epidemiológiai adat, régóta kutatás tárgya. Célkitűzés: A szívinfarktus gyakoriságának, az általa okozott halálozásnak diurnalis és szezonális vizsgálata nagy esetszámú, válogatás nélküli betegcsoport adatainak elemzésével. Módszer:...
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Aim Describe the characteristics, management and outcomes of hospitalized ST-segment elevation myocardial infarction (STEMI) patients according to national ongoing myocardial infarction registries in Estonia, Hungary, Norway and Sweden. Methods and Results Country-level aggregated data was used to study baseline characteristics, use of in-hospital...
Article
Aims: To study baseline characteristics, in-hospital managements and mortality of non-ST elevation MI (NSTEMI) patients in different European countries. Methods and results: NSTEMI patients enrolled in the national MI registries (EMIR; n = 5,817 (Estonia), HUMIR; n = 30,787 (Hungary), NORMI; n = 33,054 (Norway) and SWEDEHEART; n = 49,533 (Sweden...
Preprint
Recurrent graph convolutional neural networks are highly effective machine learning techniques for spatiotemporal signal processing. Newly proposed graph neural network architectures are repetitively evaluated on standard tasks such as traffic or weather forecasting. In this paper, we propose the Chickenpox Cases in Hungary dataset as a new dataset...
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Introduction: The relationship between clinical outcomes and serum anti-TNF levels is controversial. The aim of this study was to perform simultaneous analyses of serum, mucosal and faecal anti-TNF-α levels. Methods: Consecutive IBD patients who received maintenance anti-TNF-α therapy were enrolled. The number of TNF-α positive cells in the muco...
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Összefoglaló. Bevezetés: A szívinfarktust megelőző revascularisatiós beavatkozások prognosztikai jelentőségével kapcsolatban kevés elemzés ismeretes, hazai adatokat eddig nem közöltek. Célkitűzés: A szerzők a Nemzeti Szívinfarktus Regiszter adatait felhasználva elemezték a koszorúér-revascularisatiós szívműtétet (CABG) túlélt betegek prognózisát he...
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Background Although post-TAVI PAR is commonly seen, its exact evaluation, grading and the true impact on patients' survival are still debated. This single center study aimed to evaluate the effect of post transcatheter aortic valve implantation (TAVI) paravalvular aortic regurgitation (PAR) on patients' survival. The outcome was evaluated by the th...
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Introduction Bleeding and coagulopathy are leading causes of morbidity and lethal outcome after multiple injuries. The pathophysiology of traumatic coagulopathy is under extensive investigations and recent results highlighted the central role of fibrinogen and the fibrin polymerisation process. Our goal was to investigate the factors influencing fi...
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Background: The incidence of lower limb major amputations is an important healthcare quality indicator, as it reflects all efforts aimed to prevent limb loss. Analysis of within-country regional variations in incidence may reveal the sources of disparities in care. Materials and methods: Based on the data of the Hungarian healthcare beneficiary pop...
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COVID-19 epidemic has been suppressed in Hungary due to timely non-pharmaceutical interventions, prompting a considerable reduction in the number of contacts and transmission of the virus. This strategy was effective in preventing epidemic growth and reducing the incidence of COVID-19 to low levels. In this report, we present the first epidemiologi...
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Background Healthcare-associated infections represent a major burden in neonatal intensive care units. Hand antisepsis is the most important tool for prevention, however, compliance among healthcare workers remains low. Objectives To prospectively evaluate the influence of different work shifts (extended working hours, night shifts) on the quality...
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Background: Products sweetened with non-nutritive sweeteners (NNS) are widely available. Many people with type 1 or type 2 diabetes use NNS as a replacement for nutritive sweeteners to control their carbohydrate and energy intake. Health outcomes associated with NNS use in diabetes are unknown. Objectives: To assess the effects of non-nutritive...
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Absztrakt A COVID–19-járvány mindenkit, szakembert és laikust egyaránt váratlanul érintett, jóllehet egy világméretű pandémia lehetőségét egyrészről az epidemiológusok, infektológusok, másrészről szociológusok, kommunikációs, sőt társadalmi szokásokkal foglalkozó viselkedéstudományi szakemberek elméletben már régóta elképzelhetőnek tartották. Mégis...
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Background Despite the adequate antibiotic prophylaxis, the incidence and mortality rate of infective endocarditis (IE) is still high. In the past few decades, several studies have noted an increase in the proportion of IE caused by staphylococcal species. Aims The aim of our retrospective study was to assess the clinical and microbiological chara...
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Background Infective endocarditis (IE) is a rare, but life-threatening complication of cardiac device implantation. Despite recent preventive strategies, and advances in antimicrobial and surgical treatment, morbidity and mortality rates are still high. Aims The objective of our study was to assess the epidemiological characteristics, temporal ten...
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Background Faecal drug concentration is not routinely measured as per therapeutic drug monitoring strategies in inflammatory bowel disease (IBD) patients receiving anti-TNF therapy. However, our previous research work suggested the importance of faecal drug monitoring of anti-TNF agents since active disease may be present in spite of normal serum a...
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Background Anti-tumour necrosis factor (TNF) therapy has dramatically changed the treatment of inflammatory bowel disease (IBD). The relationship between clinical outcomes and serum anti-TNF levels is controversial. This study aimed to perform simultaneous analyses of the serum, mucosal and faecal infliximab and adalimumab levels to determine the m...
Article
Mathematical models of tumor growth in response to chemotherapy are crucial for therapy optimization and outcome. We create a relatively simple tumor growth model describing the antitumor effect of pegylated liposomal doxorubicin (PLD) validated with real experimental data obtained in a genetically engineered mouse model of breast cancer. We use fo...
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Objective: The aim of this study was to assess the long term trends of lower limb amputation and revascularisation in Hungary over 14 years. Methods: This was a retrospective cohort study that included all patients who underwent lower limb amputation or revascularisation over a 14 year period (2004-2017) in Hungary. Inpatient administrative data...
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Introduction: There are conflicting data on the prevalence and prognosis of AMI patients with non-obstructive coronary artery disease (MINOCA). Aim: We studied the prevalence and prognosis of MINOCA patients. Method: In the Hungarian Myocardial Infarction Registry (HUMIR) 45,223 patients (pts) with acute myocardial infarction (AMI) were found who w...
Conference Paper
Abstract Background: Adequate food intake and adequate water intake (AWI) plays a vital role in body development, human health and total wellbeing. Water intake (WI) is one of the major and crucial nutrients for health promotion and disease prevention. Beverage consumption is also a medium through which water is consumed but the content of the bev...
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Although more and more data on lower limb amputations are becoming available by leveraging the widening access to health care administrative databases, the applicability of these data for public health decisions is still limited. Problems can be traced back to methodological issues, how data are generated and to conceptual issues, namely, how data...
Article
Background There are conflicting data about the proportion and prognosis of patients (pts) with acute myocardial infarction (AMI) with nonobstructive coronary arteries (MINOCA). Purpose To define the incidence and prognosis of MINOCA pts in different types of AMI. Methods The Hungarian Myocardial Infarction Registry (HUMIR) is a nationwide, manda...
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Introduction The latest ESC/ESH guidelines recommended fixed dose combinations (FDC) for first therapy in hypertension. Preferred two-drug combinations are a RAS (renin–angiotensin system) blocker with a CCBs (calcium channel blockers) or a diuretic. There are no available data about these FDCs adherence in hypertension. Aim To assess one year per...
Article
The objective of the current study is to compare the relative performance of decision tree, neural network, and logistic regression for predicting 30-day and 1-year mortality in a real-word, unfiltered dataset (n=47,391) of patients hospitalized with acute myocardial infarction. Area under the ROC curve (AUC) was used for evaluating performance of...
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Introduction: The most recent European guidelines for the treatment of hypertension suggest the use of renin-angiotensin-aldosterone system antagonists (RAAS inhibitors) and calcium channel blockers (CCBs) or diuretics fixed-dose combinations (FDCs) as the first therapeutic option. In antihypertensive therapy, the patient's adherence is one of the...
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Introduction: In the treatment of non-valvular atrial fibrillation (AF) with oral anticoagulants (OAC), medical adherence is a relevant factor for stroke prevention. Aim: To evaluate the one-year persistence of vitamin K antagonists (VKA) and direct oral anticoagulants (DOAC) in patients suffering from AF and already treated with OACs. Method:...
Article
Background Online activity‐based epidemiological surveillance and forecasting is getting more and more attention. To date, Google search volumes have not been assessed for forecasting of tick‐borne diseases. Thus, we performed an analysis of forecasting of the Lyme disease incidence based on the traditional data extended with Google Trends. Method...
Article
Background: The authors analyzed data from the Hungarian Myocardial Infarction Registry (HUMIR) to examine the potential impact of gender on the treatment and 30-day and 1-year mortality of patients with myocardial infarction (MI). Materials and methods: The National Registry of Myocardial Infarction included 42,953 patients between January 1, 2...
Article
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Introduction: Fixed dose combinations (FDC) has a better adherence compared to free dose combinations. There are no available data to compare fixed dose combination in relation patients adherence. Aim: We assessed one year persistence FDC of renin-angiotensin-aldosterone system inhibitors (RAAS) and calcium channel blockers (CCBs) in hypertensiv...
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Introduction: Patient adherence to chronic drug treatment has a great importance to avoid adverse events. Oral anticoagulant therapy decrease significantly the risk of stroke in atrial fibrillation (AF). Aim: Our aim was to investigate the one year persistence of the newly started vitamin K antagonist (VKA) and novel oral anticoagulnts (NOACs) the...
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Background and Aims Complementary and alternative medicine (CAM) is commonly used among patients with inflammatory bowel diseases (IBD), but evidence about its real-life use is limited. We aimed to assess and compare CAM use in outpatients with IBD and other gastrointestinal diseases. Materials and Methods The use of herbs and botanicals, lifestyl...
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Introduction: The strong, positive relationship between smoking and myocardial infarction was proven in the 1960s and 1970s. The prognostic significance of smoking in the acute phase of the infarction, and later in patients who survive the acute phase is, however, not clear. Numerous international studies focus on the phenomenon called the "smoker...
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Introduction and aim: By using the database of the National Registry of Myocardial Infarction, the authors examine the prognosis of patients treated with acute myocardial infarction, in case of whom there was new or presumably new left bundle branch block (nLBBB) on the ECG recorded at hospitalization. Method: We recorded the details of 18 091 p...
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Background The introduction of anti-TNF therapy has dramatically changed the treatment of refractory inflammatory bowel disease (IBD-Crohn’s disease [CD], ulcerative colitis [UC]). However, the clinical use of anti-TNF therapies is limited by loss of response posing significant challenge for clinicians. Therapeutic drug monitoring has gained increa...
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Introduction: In the treatment of hypertension avoiding adverse cardiovascular complications to achieve target blood pressure is essential. The appropriate drug selection, and if necessary to change to combination therapy, patients adherence is important which may help fixed dose combination. Aim: The aim of the authors was to investigate the on...
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Introduction: In management of hypertension patient adherence is one of the most important factors. In hypertension the cardiovascular risk reduction can be reached only by prolonged and effective pharmacotherapy. Aim: To evaluate the persistence of one-year treatment of free and fixed-dose combination of perindopril/amlodipine in hypertension....
Article
Background: CT-P13, the first biosimilar monoclonal antibody to infliximab (IFX), has been confirmed to be efficacious in inducing remission in inflammatory bowel diseases (IBD). The aim of this study was to evaluate the long-term efficacy and safety of CT-P13 therapy in Crohn's disease (CD) and ulcerative colitis (UC), and to identify predictors...
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Null hypothesis significance testing dominates the current biostatistical practice. However, this routine has many flaws, in particular p-values are very often misused and misinterpreted. Several solutions has been suggested to remedy this situation, the application of Bayes Factors being perhaps the most well-known. Nevertheless, even Bayes Factor...
Article
Introduction and aim: The aim was to study the patients' adherence to some evidence-based medication (statins, beta blockers, platelet and RAS inhibitors) after suffering a myocardial infarction, and its impact on the outcome. Method: Retrospective observational cohort study was carried out from the data of the Hungarian Myocardial Infarction Re...