Takumi Nishi's research while affiliated with Fukuoka Institute of Health and Environmental Sciences and other places

Publications (30)

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The aim of this study was to investigate the association between pulse pressure (PP) and chronic kidney disease (CKD) progression among the general population in Japan. We conducted a population-based cohort study of the residents of Iki Island, Nagasaki, Japan, from 2008 to 2018. We identified 1042 participants who had CKD (estimated glomerular fi...
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How do people change their healthcare behavior when a public health crisis occurs? Within a year of its emergence, coronavirus disease 2019 (COVID-19) has gradually infiltrated our lives and altered our lifestyles, including our healthcare behaviors. In Japan, which faces China across the East China Sea and accepted 924,800 Chinese tourists in Janu...
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Background Cost sharing, including copayment and coinsurance, is often used to contain medical expenditure by decreasing unnecessary or excessive use of healthcare resources. Previous studies in Japan have reported the effects of a coinsurance rate reduction for healthcare from 30 to 10% on the demand for healthcare among 70–74-year-old individuals...
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Background It is unclear whether women have a higher risk of stroke than men. This study aimed to clarify the effects of a sex difference on the risk of ischaemic stroke in patients with atrial fibrillation (AF). Methods Health check and insurance claims data were used of people who were aged <75 years from 2005 to 2017 in Japan. Patients with AF...
Article
Objective Among patients with atrial fibrillation, the risks of ischaemic stroke and systemic embolism (IS/SE) are high even with effective anticoagulation. Using large-scale, real-world data from Japan, this study aims to clarify residual risks of IS/SE attributable to modifiable risk factors among patients with atrial fibrillation who are taking...
Article
Introduction: Evidence using real-world data is sparse regarding the effects of oral anticoagulants (OACs) among patients with kidney disease. The aim of this study was to investigate the effects of kidney disease on ischemic stroke (IS) or systemic embolism (SE) among patients taking OAC, using large-scale real-world data in Japan. Methods: Thi...
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Background This large‐scale observational study on negative events in a real‐world setting investigated Japanese patients with atrial fibrillation who were not on anticoagulants. This study aims to evaluate the incidence of ischemic stroke and bleeding events (intracranial hemorrhage, gastrointestinal bleeding, others) based on CHA 2 DS 2‐ VAS c sc...
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Background This study aimed to evaluate the effects of income levels on physician visit patterns and to quantify the consequent impact of irregular physician visits on glycemic control, among employees’ health insurance beneficiaries in Japan. Method We obtained specific health check‐up data on untreated diabetes patients from the Fukuoka branch o...
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Objective: The aim of this study was to examine whether anesthetic technique is associated with 30- or 90-day mortality and perioperative length of stay (LOS). Design: We used a retrospective cohort design using a healthcare insurance claims database. Setting: The Fukuoka Prefecture's claims database of older patients who underwent hip fractur...
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Background This study aimed to investigate the rate of first-generation H1-antihistamines use for older adults with dementia in Japan. Methods The study design was retrospective cohort using claims data between fiscal years 2010 and 2013. Subjects were 75 years or older, diagnosed with dementia, and given H1-antihistamines orally during the study...
Data
Supplementary Table 1: list of first-generation H1-antihistamine drugs used for analyses. Supplementary Table 2: rate, crude, and adjusted odds ratio of first-generation H1-antihistamine use. Supplementary Table 3: rate, crude, and adjusted odds ratio of first-generation H1-antihistamine use after excluding cold medication.
Article
Aim The present study aimed to investigate the effects of the 2014 Japanese fee schedule revision on trends in artificial nutrition routes, including gastrostomy, nasogastric tube and parenteral nutrition, among older people with dementia, using time series analysis. Methods The study used claim data in Japan submitted to Fukuoka Late Elders' Heal...
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Purpose Dipeptidyl peptidase‐4 (DPP‐4) inhibitors are a new class of antidiabetic drugs. Although they have been reported to increase the risk of infection, the findings are controversial. Given that urinary tract infections (UTIs) are common in the elderly, we conducted a retrospective cohort study by using health care insurance claims data, to el...
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The incidence rates of hip fracture have been increasing in Japan. Length of stay among hip fracture patients in Japan is much longer than other developed countries, and the Japanese government introduced financial incentives for regionally coordinated femoral neck fracture care to reduce health care resource utilization. The objective of this stud...
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Objective: To examine the impact of inter-provider care coordination on health-care resource utilization among elderly acute stroke patients. Design: A retrospective cohort study using health-care insurance claims data. Setting: Claims data of the Fukuoka Prefecture Wide-Area Association of Latter-Stage Elderly Healthcare. Participants: Abou...
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There is a possibility that unnecessary treatments and low-quality medical care, such as inappropriate indwelling urethral catheter use, are being provided to older Japanese individuals. The aim of this study was to investigate contextual effects relating to indwelling urethral catheters in older people with dementia and to clarify the effects of i...
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Introduction: The aim of this study was to quantify the effects of diabetes with pharmacotherapy-treated breast cancer on care resource use. Materials and Methods: The study was designed as a single institutional retrospective cohort study using hospital administrative data. The subjects were 152 patients admitted to a hospital from 2008 to 2012 di...
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The aim of this study is to clarify whether there is small area variation in the use of gastrostomy that is explained by hospital physician density, so as to detect the existence of supplier-induced demand (SID). The study design is a retrospective cohort using claim data of Fukuoka Late Elders’ Health Insurance, submitted from 2010 to 2013. Study...
Article
Few studies have evaluated the effects of lifestyle habits, such as eating behaviors, on the development of nonalcoholic fatty liver disease (NAFLD). It is known that NAFLD increases the risk of type 2 diabetes, prediabetes, cardiovascular disease, and chronic kidney disease. Therefore, a retrospective cohort study was conducted to evaluate the eff...
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Background: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide. Renin-angiotensin system (RAS) inhibitors are the first-line treatment for diabetic patients with hypertension. However, whether RAS inhibitors prevent the development of DKD remains controversial. We conducted a retrospective cohort study quantify...
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We examined the impact of opportunistic infections on in-hospital mortality, hospital length of stay (LOS), and the total cost (TC) among adult T-cell leukaemia (ATL) patients. In this retrospective cohort study, we identified 3712 patients with ATL using national hospital administrative data. Analysed opportunistic infections included Aspergillus...
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Objective Older people are more likely to have insomnia. One of the most prescribed hypnotics in Japan is triazolam. Although some studies showed the possibility of adverse effects of triazolam in older people, there have been few studies investigating these effects in a clinical setting. The aim of this study was to determine whether patients who...
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Aims/IntroductionNon-alcoholic fatty liver disease (NAFLD) is the most common liver disease in developed countries, and it was required to monitor patients with prediabetes. However, there have been few reports establishing the risk for diabetes mellitus (DM) among patients with prediabetes. The purpose of the present study was to evaluate the effe...
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Objective The aim of this study was to quantify the effects of psychiatric disorders on major surgery outcomes and care resource use. Methods This study adopted a retrospective cohort study design. The samples consisted of hospital stays. Subjects were patients who had undergone major surgery. We used multilevel regression analysis to quantify the...
Article
This study aimed to quantify the risks of Pneumocystis pneumonia (PCP) among adult T-cell leukaemia (ATL) patients without prophylaxis. We used hospital administrative data collected nationwide in Japan over 4 years. The research design was a retrospective cohort study. Subjects were 4369 patients diagnosed with ATL aged 18 years or older. The subj...
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Background Japan has a high prevalence of adult T-cell leukaemia (ATL), especially in the Kyushu/Okinawa region. Regional differences in prevalence might cause regional differences in physicians’ experiences and the efficiency of care-resource use. This study investigated regional differences in the performance of bone marrow transplantation (BMT),...
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Aims/IntroductionThe objective of the present study was to evaluate the risk of diabetic macrovascular complications and in-hospital mortality among diabetic patients with irregular physician visits. Materials and Methods We carried out a health insurance-based retrospective cohort study using claims data from diabetic patients who were newly hospi...
Article
Abstract This study examined the impact of expenditures for preventive health care services on health care costs among those insured with health insurance societies in Japan using cross-sectional and longitudinal designs. The subjects of the study were those insured with Japan's 1481 health insurance societies belonging to the National Federation o...

Citations

... The Jordan AF study represents the first contemporary study that addresses management practices and major cardiovascular events after one-year of follow-up in a relatively large Middle Eastern cohort of patients enrolled in the era of an increasing utilization of the newer OACs to prevent stroke and SE. The principal findings of the study are as follows: (i) the majority of AF patients (9 of 10) had NVAF; (ii) the majority of patients with NVAF had highrisk CHA2DS2-VASc score (∼80%); and (iii) rates of incidence of major cardiovascular events at one-year of followup were comparable to those reported by studies from other regions in the world [22][23][24]. The AF population we studied was mostly patients with NVAF. ...
... For example, age, smoking, hypertension, and diabetes were included in all previous Japanese stroke risk models [18][19][20][21][22][23][24]. CKD was shown to be associated with stroke in Japanese patients even after adjustment for traditional cardiovascular risk factors, including hypertension [33][34][35][36]. AF was included in the JALS stroke risk model [24] and was found in other Japanese studies to be associated with the increased risk of stroke [25,26]. ...
... 5 As a supraventricular tachyarrhythmia, AF has been associated with degraded health-related quality of life, diminished exercise capacity, ischemic cerebral stroke or extracranial systemic thromboembolism, impaired cognition or dementia, chronic kidney disease, acute myocardial infarction, tachycardia-induced cardiomyopathy, congestive heart failure, sinoatrial node dysfunction, ventricular arrhythmias, and sudden cardiac death. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] In fact, AF confers a 4-to 5-fold increased risk of ischemic stroke, accounting for 15% of all strokes, a 5-fold increased risk of heart failure, and a 2-fold increased risk of demise. 20 Therefore, AF has become a major socioeconomic burden, given that existing treatment regimens are limited in efficacy and are seldom curative. ...
... As reported by Nishi et al, 27 individuals with low income tend to avoid regular check-ups and, consequently, have poorer control over their blood sugar levels than those with high income. Individuals with low income have limited access to materials and services, such as a balanced diet and healthcare facilities required to prevent diabetes onset. ...
... The low incidence of those side effects can not only effectively improve patient satisfaction but also help patients recover faster after surgery [25]. Our meta-analysis confirms previous studies reporting decreased postoperative side effects associated with FNB [3,26,27]. ...
... Many older adults, however, especially those with chronic medical conditions causing sleep disturbance, turn to OTC drugs with H1RA to improve sleep without paying attention to their potential risks (Abraham et al., 2017). One retrospective study of patients aged 75 years or older diagnosed with dementia in Japan, based on claims data between 2010 and 2013, found a total of 12,658 participants in the study, with 8,272 (65.3 %) of them receiving first-generation H1RA (Maeda et al., 2018). The finding in this study might well serve as a reminder for the clinicians caring for those who have been exposed to H1RA about the potential disadvantage and risk of dementia in individuals aged ≥65 years. ...
... Symptomatic hypoglycemia, pancreatitis (acute or chronic), skin disorders of non-extrinsic origin, severe infections, and cancer were collected as major AEs. [18][19][20][21][22] Microvascular and macrovascular complications were also collected. AE terms were referred to MedDRA V.15.1. ...
... PFC programs are generally cost-effective, but there is a high degree of variability in cost-effectiveness given the heterogeneity in resourcing, PFC structures, and outcomes being measured. We identified reports that compared costs of FLSs with costs of standard of care [27,70], costs between different FLSs [71], costs of OGS/hip fracture programs vs. standard of care [72], reimbursement related to PFC programs [72][73][74], and socioeconomic status and financial considerations [75,76]. Details of the identified studies are provided in Online Results 1, under the subheading of Studies on PFC Economics. ...
... Figure 2 presents the types of financial incentives and intervention settings that were identified in the literature. We identify 8 studies investigating the role of rewards in primary care and one study focusing on rewards in hospitals [41]. Reimbursement mechanisms are discussed with relation to primary care in three studies [28,42,43] and hospitals in three studies [28,29,39]. ...
... Perhaps these SMAs have better health care provision, including emergency care services. Furthermore, the high physician-to-population ratio in these SMAs, as reported by Maeda et al. [47], might also explain these findings. Our analysis did not show sizable variations in LOS or total hospitalization cost across SMAs. ...