Takahiro Miyakoshi's research while affiliated with Aizawa Hospital and other places

Publications (9)

Article
Full-text available
Background/objectives: It has been unknown if attenuated insulin sensitivity (Si) in non-alcoholic fatty liver disease (NAFLD) is a cause or a result. We examined the impact of attenuated Si on NAFLD evolution. Subjects/methods: We observed 4856 NAFLD- and diabetes-free participants for a mean 2.9 years. Si was indexed by single point insulin se...
Article
Full-text available
Purpose We aimed to clarify the onset of diabetes. Methods Data from 27,392 non-diabetic health examinees was retrospectively analyzed for a mean of 5.3 years. Trajectories of fasting plasma glucose (FPG), body mass index (BMI) and the single point insulin sensitivity estimator (SPISE), an index of insulin sensitivity (Si), 10 years prior to diagn...
Article
A hypothesis that postchallenge hyperglycemia in subjects with low body weight (BW) may be in part due to small glucose volume (Gv) was tested. We studied 11,411 non-diabetic subjects with a mean BW of 63.3 kg. 5,282 of them were followed for a mean of 5.3 years. In another group of 1,537 non-diabetic subjects, insulin sensitivity, secretion, and a...
Article
Full-text available
Objective: To describe hypocalcaemia due to vitamin D deficiency in ‘hikikomori’ syndrome. Materials and methods: A 37-year-old man with ‘hikikomori’ syndrome for a year was admitted with hypocalcaemia (serum ionic calcium 1.17 mmol/l). Serum 1,25(OH)2-vitamin D3 determined by liquid chromatography–tandem mass spectrometry was depressed at 12.1 pg/...
Article
Aim: To clarify the natural course of prediabetes and develop predictive models for conversion to diabetes. Methods: A retrospective longitudinal study of 2105 adults with prediabetes was carried out with a mean observation period of 4.7years. Models were developed using multivariate logistic regression analysis and verified by 10-fold cross-val...
Article
To develop diabetes risk score (RS) based on the current definition of diabetes, we retrospectively analyzed consecutive 4,159 health examinees who were non-diabetic at baseline. Diabetes, diagnosed by fasting plasma glucose (FPG) ≥7.0 mmol/L, 2hPG ≥11.1 mmol/L and/or HbA1c ≥6.5% (48 mmol/mol), developed in 279 of them during the mean period of 4.9...
Article
Background/objectives: The quantitative impact of weight gain on prediabetic glucose dysregulation remains unknown; only one study quantitated the impact of weight loss. We quantified the impact of weight gain on the evolution and regression of prediabetes (PDM). Subjects/methods: In 4234 subjects without diabetes, using logistic regression anal...
Article
Aim: Risk profile for incident chronic kidney disease (CKD) in Japanese subjects has not been established. Methods: Consecutive 171536 health examinees (median age 49 yrs and estimated glomerular filtration rate (eGFR) 78.2 mL/min/1.73 m(2) ) without CKD were re-examined after a median period of 6.2 yrs. Results of Cox proportional hazards model...

Citations

... Among these, the SPISE was developed as an easy and affordable tool for the evaluation of whole-body insulin sensitivity, which is comparable to clamp-derived M-value in sensitivity as well as specificity (19). Several studies have evaluated the SPISE in adult as well as juvenile populations (20,(41)(42)(43)(44)(45)(46). Correa-Burrows et al. assessed SPISE for its validity in diagnosing cardiometabolic risks, namely IR and metabolic syndrome, in post-pubertal Hispanic adolescents. ...
... In particular, the risk factors for type 2 diabetes and their contributions in the initial phases of the disease remain uncertain [1,[3][4][5][6][7][8][9][10][11]. Specifically, the trajectory of plasma glucose level before clinical diagnosis of diabetes and prediabetes reveal that a stable, long-lasting, slow elevation is followed by an accelerated rise for several years before the diagnosis [7,[12][13][14][15]. This so-called multistage model strongly suggests unfavorable interactions between minimally elevated glucose per se and the glucose regulatory mechanism. ...
... Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated, as reported in the original study: (FPG × fasting immunoreactive insulin)/405, where the units of measurement are mg/dL for FPG and μU/mL for immunoreactive insulin [14]. Then, the reciprocal of HOMA-IR, 1/HOMA-IR, was adopted as the reference for Si [15], 1/HOMA-IR and SPISE were compared in 1537 non-diabetic health examinees at Iida Municipal Hospital (sex ratio 950:587, mean age 52.8 years), whose characteristics are shown in Supplemental Table 1 [16]. ...
... Koda reported an eating disorder and vitamin D deficiency in a patient, which was caused by a combination of inadequate nutrition intake and lack of sunlight [10], as seen in our case. Miyakoshi reported that "Hikikomori" causes calcium and vitamin D deficiency due to a lack of sunlight exposure [11]. On a sunny day in Japan, the skin can produce adequate vitamin D in only 10 min [12]. ...
... However, these symptoms in T2D are not easily noticeable or may be completely absent due to the gradual progression of disease. Recently many studies have reported that pre-diabetes in itself is marked by serious micro-vascular and macro-vascular complications similar to those of diabetes (Bowen et al. 2018;Yudkin 2016;Yokota 2017). The risk composition of T2D consists of various parameters, which can be broadly categorized into modifiable and non-modifiable risk factors. ...
... Offspring (FOS) Risk [19]. Most T2DM prediction models use logistic [20][21][22] or Cox regression [23][24][25] and use carriage return and automatic direction forward selection, backward elimination, or step-by-step procedures. In this study, the nomogram first constructs a multifactor regression model (LASSO regression and logistic regression), and assigns each value level of each influencing factor according to the degree of contribution of each influencing factor in the model to the outcome variable (the size of the regression coefficient). ...
... Apart from overweight and obesity, weight gain may also increase the risk of progression from prediabetes to diabetes through increased insulin resistance [12,33]. Weight gain, particularly accumulation of visceral fat, could increase inflammation around liver and impair insulin signalling, which in turn worsens insulin sensitivity [34]. ...
... Their findings support the importance of FPG in those with diabetes, as well as in the general elderly population. For non-diabetic population, several previous studies have investigated the role of FPG in reduced renal function [27]. Koshi proposed that FPG was not an independent risk factor for incident CKD (CKD free at baseline but developed into CKD at the follow-up) in 2483 non-diabetic individuals aged 48 ± 8 years, with a mean observation period of 5.3 years [28]. ...