Tai-Wen Wang's research while affiliated with National Chiao Tung University and other places

Publications (2)

Article
Full-text available
Background The human CISD2 gene is located within a longevity region mapped on chromosome 4q. In mice, Cisd2 levels decrease during natural aging and genetic studies have shown that a high level of Cisd2 prolongs mouse lifespan and healthspan. Here, we evaluate the feasibility of using a Cisd2 activator as an effective way of delaying aging. Metho...
Article
Full-text available
CDGSH Iron Sulfur Domain 2 (CISD2) is the causative gene for the disease Wolfram syndrome 2 (WFS2; MIM 604928), which is an autosomal recessive disorder showing metabolic and neurodegenerative manifestations. CISD2 protein can be localized on the endoplasmic reticulum (ER), outer mitochondrial membrane (OMM) and mitochondria-associated membrane (MA...

Citations

... Most strikingly, in Cisd2 transgenic mice, increased Cisd2 expression delays cardiac aging and ameliorates age-related cardiac dysfunction [24,30]. Consistently, an elevated level of Cisd2 has been found to delay skeletal muscle aging [17], to slow down liver aging [31] and attenuate liver carcinogenesis [23], as well as reducing Alzheimer's-related neuronal loss [32,33]. Collectively, these mouse genetic studies confirm that Cisd2 is a key player that controls lifespan and healthspan. ...