TS Anitha's research while affiliated with Sri Balaji Vidyapeeth University and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (17)
Introduction Glioma, coined as a “butterfly” tumor associated with a dismal prognosis. Marine algal compounds with the richest sources of bioactive components, act as significant anti-tumor therapeutics. However, there is a paucity of studies conducted on Fucoidan to enhance the anti-glioma efficacy of Temozolomide. Therefore, the present study aim...
Background
Glioblastomas arise from multistep tumorigenesis of the glial cells and are associated with poor prognosis. Despite the current state-of-art treatment, tumor recurrence is inevitable. Thus, there exists a desperate need for effective therapeutic alternatives to improve glioblastoma outcome. Among the innovations blooming up, drug repurpo...
Introduction
Glioma, coined as a “butterfly” tumor associated with a dismal prognosis. Marine algal compounds with the richest sources of bioactive components, act as significant anti-tumor therapeutics. However, there is a paucity of studies conducted on Fucoidan to enhance the anti-glioma efficacy of Temozolomide. Therefore, the present study aim...
Background
An important hallmark of glioblastoma aggressiveness is its altered metabolism of glucose. This metabolic shift wherein the tumor cells employ aerobic glycolysis regardless of oxygen availability via reprogramming of mitochondrial oxidative phosphorylation is known as the Warburg effect. Previous literatures have linked this metabolic re...
Glioma is the most devastating high-grade tumor of the central nervous system, with dismal prognosis. Existing treatment modality does not provide substantial benefit to patients and demands novel strategies. One of the first-line treatments for glioma, temozolomide, provides marginal benefit to glioma patients. Repurposing of existing non-cancer d...
A series of [Mn (CO)3(L)Br] complexes (1−5) are synthesized using azachalcones as ligands, wherein they are coordinated to the manganese metal through the nitrogen and oxygen donor atoms. Their characterization using various spectroscopic techniques, stability analysis in dimethyl sulfoxide solvent, photodecomposition analysis, and anti‐proliferati...
Glioblastoma multiforme is one of the calamitous primary glial brain tumors with extensive heterogeneity at cellular and molecular levels. While maximal surgical resection trailed by radio and chemotherapy employing temozolomide remains the gold-standard treatment for malignant glioma patients, the overall prognosis remains dismal and there exists...
Aims
Malignant gliomas constitute one of the deadly brain tumors with high degeneration rate. Though temozolomide (TMZ) is the first-line drug for glioma, its efficacy has decreased due to chemo-resistance. Repurposing synthetic and natural compounds have gained increasing interest in glioma. Hence, we combined chloroquine (CHL, synthetic drug), na...
Glioma is one of the most devastating and difficult-totreat brain tumors with a very poor prognosis. Despite the current treatment modalities, the overall survival rate is only 5% contributing to a high mortality rate. Nevertheless, of emerging treatment strategies, there is still a rising need for novel mitigation strategies to counteract glioma a...
Aim
To study the synergistic anti-glioma efficacies of Temozolomide, Metformin and Epigallocatechin Gallate in U87MG and C6 glioma cells.
Background
Glioblastoma (GBM) is the most malignant and invasive tumor of the central nervous system. The current standard treatment comprises surgical resection, followed by adjuvant radiotherapy and chemothera...
Gliomas are one of the most devastating primary brain tumors which impose significant management challenges to the clinicians. The aggressive behaviour of gliomas is mainly attributed to their rapid proliferation, unravelled genomics and the blood–brain barrier which protects the tumor cells from chemotherapeutic regimens. Suspects of brain tumors...
Glioblastoma multiforme (GBM) is one of the most common aggressive and fatal forms of adult brain tumors. According to WHO classification, GBM is usually classified as a grade IV form of a brain tumor. Glioblastoma multiforme exhibits high intra- and inter-tumoral heterogeneity. Free radical generation in GBM plays a robust role in promoting and in...
Genome editing employs targeted nucleases as powerful tools to precisely alter the genome of target cells and regulate functional genes. Various strategies have been risen so far as the molecular scissors-mediated genome editing that includes zinc finger nuclease, transcription activator-like effector nucleases, and clustered regularly interspaced...
Citations
... Naringenin was found to repress Erk1/2 and p38 activities at concentrations of 100, 200 and 300 μM. The inhibition of Erk and p38 was then found to be involved in MMP-2 and MMP-9 expression, which revealed naringenin's ability to inhibit the migration of glioblastoma cells [88][89][90][91]. Decreased levels of MMP-2 and -9 were found to correlate with increased expression of TIMP-1 and -2. ...
... For example, the IDH mutation has recently been found to be associated with decreased immune cell infiltration (12), whereas inactivated NF1 has been associated with increased macrophage infiltration (13). In addition, several major signaling pathways like NFkB, Wnt, and PI3K-AKT-mTOR are reported to be involved in the pathogenesis of GBM and have been used as therapeutic targets for GBM (14)(15)(16). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1176682358681601-1657554344002_Q64/Indrani-Biswas-5.jpg)
... The acridine orange and ethidium bromide (AO/EB) dual staining was implemented on the complexes as well as the free ligands in order to assess the suppression of U-87 MG cell proliferation and to establish the relationship between the cytotoxicity obtained from the MTT analysis and the induced apoptosis or necrosis of the cells. [47] A green shade is imparted to the nucleus when AO intercalates in the DNA of the live cells. This is considered to be an indicator of viability. ...
... Even after consent is obtained, the anonymization of images (to which identifiers are often attached) poses a significant processing burden and risk for re-identification [4]. Finally, the question arises of whether patients should be given the option to not include ML in their care [58,66]. ...
... In brain tumors, oxidative stress also plays a key role. Excess free radicals change the chromosome structure, extensively damage DNA, cause genetic mutation, and develop tumors (Anitha et al. 2020). On the other hand, irregular production of ROS leads to apoptosis of tumor cells and makes an unfavorable environment for the survival of these cells (Orlicka-Płocka et al. 2021). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/604034327134209-1521024414690_Q64/Mariappan-Vignesh.jpg)
... Clustered regularly interspaced short palindromic repeats and CRISPR associated protein-9 (CRISPR-Cas9) acts as "molecular scissors" and is quicker, more precise, and more effective than alternative genome-editing strategies. 94 CRISPR-Cas9 has also shown great potential in the treatment of cancer, including HCC. 95,96 Wang et al reported that the knockout of CXC chemokine receptor 4 (CXCR4), associated with a poor prognosis in HCC, by CRISPR/Cas9 not only suppresses proliferation and invasion but also increases sensitivity to the anticancer drug cisplatin in HCC. 97 Another study has shown that the CRISPR/ Cas9-mediated knockout of nuclear receptor binding SET domain-containing protein 1 inhibits the ability of HCC cells to proliferate and migrate. ...
