T.S. Anirudhan's research while affiliated with University of Kerala and other places

Publications (253)

Article
According to the World Health Organization (WHO), fatality of cancer is 9.6 million in 2018. Of these, 1.8 million deaths are due to colorectal cancer. However, it doesn't seem that proper medications are unavailable. Instead, the medications should reach the site of action without causing any further side effects. With the advent of smart biomater...
Article
Combination chemotherapy has attracted more attention in the field of anticancer treatment due to the synergetic effects achieved in the targeted delivery of anticancer drugs. In the present work a hydrogel-based drug delivery system (CS-NSA/A-HA) was successfully developed from chitosan modified by nitrosalicylaldehyde and aldehyde hyaluronic acid...
Article
Molecular imprinting technique (MIT) with electrochemical sensing provides an attractive tool for the fabrication of sensors. Incorporation of conducting copolymer and surface imprinting strategies in the sensing device improves the conducting properties and poor template accessibility, slow binding kinetics at the same time. Here, this technique w...
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Full-text available
The hydrophobicity of most of the anticancer drugs offers a great challenge in selecting a system for their effective transport. Here comes the importance of micelles that offers a hydrophobic core for incorporating these drugs. In this study, Hyaluronic Acid coated Pluronic mixed micelle loaded with Paclitaxel and Curcumin was designed and evaluat...
Article
A silylatedgraphene oxide (Si-GO) based electrochemical sensor was fabricated for the selective and specific detection of a diabetes biomarker 2-Aminoadipic Acid (2-AAA). The fabrication was preceded by molecularly imprinting technology accompanied by electrochemical sensing. Different molecularly imprinted polymers (MIPs) were prepared using diffe...
Article
The design and development of self- assembled hydrogels with macroscopic ordering for the controlled delivery of drug is an emerging area of research interest. The present work describes the development...
Article
Nano-scale drug delivery systems have captivated the scientific community due to their controlled and targeted drug release. Nano carrier-based combination chemotherapy has improved pharmacokinetics of drugs compared to single drug administration. The objective of the present work is to develop a drug delivery system based on aminated mesoporous si...
Article
Targeted delivery and controlled release of drugs are attractive methods for avoiding the drug's leakage during blood circulation and burst release of the drug. We prepared a nano cellulose-based drug delivery system (DDS) for the effective delivery of curcumin (CUR). In the present scenario, the role of nanoparticles in fabricating the DDS is an i...
Article
A novel magnetically separable cysteine-modified graphene [email protected] ferrite @Titanium dioxide ([email protected]2O4@TiO2) composite was fabricated for the effective removal and subsequent photodegradation of the pesticide, chlorpyrifos (CP) from aqueous solutions. The composite material was characterized by DRS, FTIR, Surface Area Analyser,...
Article
A visible-light-driven photocatalyst, nanohydroxy apatite decorated carboxyl functionalized graphene oxide/zinc oxide nanorod ([email protected]/ZnR) composite was prepared and well characterized by FTIR, XRD, SEM/EDS, HRTEM, XPS, AFM, Raman, DRS, Surface area analyser, PL and EIS. [email protected]/ZnR composite exhibited high photoactivity and ph...
Article
Molecularly imprinted allyl trimethoxysilane –grafted- graphene oxide/gold nano particle co polymerised with -allyl amine (AA) /2-aminoethyl methacrylate hydrochloride (AEMA) polymer (GO/AuNP-g-ATMS-co-AEMA/AA) was synthesised by bulk imprinting method. The synthesised product was tested for sensing and quantifying methylmalonic acid (MMA) in blood...
Article
The DDS based on isocyanato functionalized layered double hydroxide (LDH-NCO), folic acid conjugated thiolated chitosan (TCS) and gold nanoparticle (AuNp) was used for actively targeted chemophotothermal therapy of breast cancer. The LDH-NCO was conjugated to TCS and forming LDH-NCO-TCS composite. The AuNp are appended on the surface of the LDH-NCO...
Article
An adsorbent Stearyl Alcohol (SA) - grafted- epichlorohydrin (E) -grafted- aminoproypyl silanetriol (APST) was synthesized, functionalized with sulfonic acid by sulfonation process [(SA-g-E)-g-APST/ SO3H]. The characterization of the adsorbent material was done using FTIR, XRD, SEM and TGA analyses. Adsorption behaviour of bovine serum albumin (BSA...
Article
The present study aims at the synthesis of a magnetic titanium dioxide (mTiO2) incorporated conducting molecularly imprinted polymer (mTiO2-MIP) for the visible light driven degradation of a priority pollutant, diuron (DU). The prepared photocatalyst, mTiO2-MIP was characterized using FT-IR, XRD, SEM, AFM, TEM, VSM, XPS, UV–Vis DRS, photoluminescen...
Article
Graphene oxide (GO) was first modified to amine functionalized GO (AGO) and acts as a cationic polyelectrolyte. Chitosan (CS) was conjugated with folic acid (FA) through N, N´ -Dicyclohexylcarbodiimide coupling to form FA-CS. After this, itaconic acid and acrylic acid monomers are grafted to the hydroxyl group of CS using ethyleneglycol dimethacryl...
Article
Chemotherapy using single drug is not successful now a days due to the emergence of multidrug-resistant cancer cells. In the present work, Methotrexate (MTX) and Mitomycin C (MMC) loaded hydrogel sensitive to both reduction and pH are prepared and well characterized using various instrumentation techniques like FTIR, XRD, SEM and TEM. The drug load...
Article
With the purpose of avoiding leakage of drug during blood circulation and burst release of the drug at the tumor site, a functionalized magnetic Fe3O4 drug delivery system (DDS) with pH and temperature sensitivity was developed for the controlled delivery of 5-fluorouracil (5FU). Fe3O4 nanoparticles were coated with glycidyl methacrylate grafted de...
Article
Nitrogen and sulfur dual-doped ordered mesoporous carbon has been synthesized from a novel polybenzoxazine using resorcinol, 2-aminothiazole, formaldehyde and different ampliphilictriblock copolymers by a simple one-pot strategy. The structure, morphology, and elemental compositions of the carbon was characterized using X-ray diffraction, raman spe...
Article
2,4-Dichlorophenoxyacetic acid (2,4-D) is one of the well-known commercial herbicides hailing from phenoxy family whose impulsive use becomes a serious threat to aquatic ecology and mankind. Herein we report a novel photocatalyst, TiO2 nanotubes/silylated graphene oxide-based molecularly imprinted polymer ([email protected]) for the adsorption and...
Article
Dual stimuli responsive polyelectrolyte nanoparticles have been developed for chemo-photothermal synergistic therapy of colon cancer cells. This novel system is formed by layer by layer (LbL) assembly, which is composed of aminated nanodextran (AND) and carboxylated nanocellulose (CNC) deposited on the surface of chemically modified graphene oxide...
Article
Owing to poor skin permeability, the transdermal (TRD) drug delivery at the required therapeutic rate still remains an arduous task. In the present investigation, a novel TRD enhancement strategy was introduced using the synergistic effect of gold nanoparticle (GNP) and skin electroporation. Diclofenac sodium (DS) was selected as a model drug. An e...
Article
Colorectal cancer is the third most principal reason of death due to cancer. The applicability of the chemo drug, 5-Fluorouracil (5-FU) is limited due to its non-specificity, low bioavailability and overdose. The efficiency of 5-FU in colorectal cancer therapy could be enhanced by nanoencapsulation and combinatorial approach with Bisdemethoxycurcum...
Article
A new adsorbent sulfhydryl and carboxyl functionalized magnetite nanocellulose composite [(MB-IA)-g-MNCC] was synthesized by graft co-polymerization of itaconic acid onto magnetite nanocellulose (MNCC) using EGDMA as cross linking agent and K2S2O8 as free radical initiator. The adsorption occurs maximum in the pH 6.5. The best fitted kinetic model...
Article
A graphene oxide (GO)-based electrochemical sensor, trimethyl silane propyl methacrylate-GO copolymerized with 2-hydroxymethacrylate/methyl methacrylate [TMSPMA-GO-co-HEMA/MMA], to detect creatinine (Cn) was fabricated by molecular imprinting technology followed by electrochemical detection. Electrochemical measurements were made by cyclic voltamme...
Article
Gold nanoparticles (AuNP) have attracted ample attention as a transdermal (TND) drug delivery platform for improving the skin permeability of drug molecules. Herein a novel TND device formed from AuNP and oleylamine functionalized nanodiamond (AuD) has been developed successfully for the TND delivery of Ketoprofen (KP), a model drug. Polyvinyl alco...
Article
A novel amidoxime functionalized adsorbent, poly(amidoxime)-grafted-chitosan/bentonite composite [P(AO)-g-CTS/BT] was prepared by in situ intercalative polymerization of acrylonitrile (AN) and 3-hexenedinitrile (3-HDN) onto chitosan/bentonite composite using ethylene glycol dimethacrylate (EGDMA) as cross linking agent and potassium peroxy disulpha...
Article
A novel zinc oxide nanorod incorporated carboxylic graphene/polyaniline ([email protected]/PANI) composite was synthesized for the effective removal and subsequent photodegradation of the pesticide diuron (DU) from aqueous solutions. The photocatalyst was characterized by FTIR, XRD, SEM, TEM, Surface Area Analyzer, Raman spectroscopy AFM, DRS, PL a...
Chapter
5-Fluorouracil (5-FU) is a widely used anticancer drug. To minimize the toxic side effects of 5-FU, a suitable drug delivery system (DDS) is needed for its controlled release. In the present chapter, we conducted a study that compared two different controlled-release systems into which 5-FU had been incorporated. The two delivery systems compared w...
Article
Silylated Graphene oxide–grafted-chemically modified nanocellulose (Si-GO-g-CMNC) is fabricated for selective sensing of Cholesterol. Zinc oxide (ZnO) incorporated in chemically modified nanocellulose (CMNC) for enhancing the conducting nature. The sensitivity of sensor was checked by modifying the glassy carbon electrode surface (GCE) with Si-GO-g...
Article
A rapid, effective and simple method for quantitative determination of Bisphenol-A (BPA) is important in environmental monitoring and health perspectives. In this work, a multi-walled carbon nanotube (MWCNT) based molecularly imprinted polymer (MIP) was successfully developed and used for modifying glassy carbon electrode (GCE) for the electrochemi...
Article
The aim of the present study was to develop a novel pH sensitive gelatin methacrylate hydrogel for the controlled delivery of Gentamicin (GS) and Ampicillin (Amp). GS and Amp having synergistic activity is effective in killing multi drug resistant bacteria. The hydrogel was well characterized using FTIR, XRD and SEM techniques. The drug loading and...
Article
A novel drug delivery system is architectured at achieving systematically improved therapeutic success for drugs including those that have limited use because of toxicity, uneven distribution pattern, stability and formulation of difficulties. In the present work, we report on the preparation of a novel composite formulation, i.e., biodegradable Th...
Article
Transdermal (TD) drug delivery is an attractive technique for drug delivery compared to oral and intravenous injection. However the permeation of drug molecules across the skin is difficult due to the presence of highly ordered lipid barrier. This investigation details the development of a novel TD system, which has the potential to simultaneously...
Article
Full-text available
Thorium(Th) contamination in the ground water an emerging environmental issue and Th recovery from sea water and nuclear wastewater is of high significance, as it is a major player in the energy sector. For the adsorption and recovery of Th, polymer grafted bio materials are reported as most efficient materials. P(IA/MAA)-g-NC/NB was prepared and a...
Article
With the advent of smart biomaterials, environmental stimuli have always been the trigger for targeted drug delivery. Conventional routes of drug administration suffer from serious drawbacks like first pass metabolism,...
Article
The present work proposes the synthesis of chitosan (CT), nanocellulose (NC) and sodium alginate (Na-Alg) based polymeric system as a dual drug carrier for 5-Fluorouracil (first line anticancer drug) and Levamisole hydrochloride (a biomodulator). Carboxylated NC-CT composite was coated with Na-Alg and further modified with vinyl monomers to impart...
Article
Due to changing lifestyles of modern world, cardiac failures are increasing day by day. Drug delivery systems that can overcome the drawbacks of conventional drug administration are highly desired. Diltiazem hydrochloride (DTZ) is a common and effective drug used for cardiac failures. However, its efficient loading, high bio availability and sustai...
Article
A novel potentiometric sensor was developed with high selectivity and sensitivity for the detection of hemoglobin using surface modified multiwalled carbon nanotube (MWCNT). MWCNT is first oxidized using concentrated nitric acid, and then grafted with epichlorohydrin (ECH). The epoxide ring present on the surface of MWCNT reacts with allyl alcohol...
Article
In the present study, a magnetic protein-polyelectrolyte complex of casein coated iron oxide nanoparticles and folic acid conjugated chitosan-graft-poly(2-dimethylaminoethyl methacrylate) was prepared for the delivery of an anticancer drug, 5-fluorouracil (5-FU) and characterized using FTIR, XRD, VSM, FESEM, TEM, DLS and zeta potential studies. Sus...
Chapter
The field of biopolymer-clay mineral composites is enjoying high resurgence of interest as drug delivery vehicles for oral applications owing to their excellent properties of degradation, biocompatibility, and tunable mechanical properties. The present work reveals the potential uses of novel hybrids of carboxymethylated starch and smectite clay mi...
Chapter
Functionalized nanomaterial composites are interesting materials in the field of toxic metal removal by adsorption process. A novel multicarboxyl-functionalized nanocellulose/nanobentonite composite [P(IA/MAA)-g-NC/NB] was synthesized by grafting biodegradable itaconic acid and methacrylic acid monomers on to nanocellulose (NC)/nanobentonite (NB) c...
Article
Transdermal (TD) route of diltiazem hydrochloride (DH) administration attracts ample attraction, but remains strenuous due to slower penetration of drug across the skin. In the present investigation, we studied the possibility of using gold nanoparticle (GNP) to enhance the skin permeation of DH. A novel TD device was fabricated from polyelectrolyt...
Article
The aim of the present work is to develop the polyelectrolyte complexes (PEc) coated on the surface of aminated mesoporous silica nanoparticles (AMSN) through layer by layer (LbL) assembly for the controlled delivery of 5-flurouracil (5-FU). The polyelectrolyte complexes coated aminated mesoporous silica nanoparticles were characterized by FTIR, XR...
Article
Full-text available
In the present work ability of the two novel adsorbents, sulphonyl and carboxyl functionalized stearyl alcohol-grafted epichlorohydrin, SA-g-E-SO3H, SA-g-E-COOH; to remove lysozyme (LYZ) from aqueous solution was assessed. The adsorbent characterization was done using FTIR, XRD, SEM and TGA analyses. The adsorption efficiency was influenced by solu...
Article
Skin cancer is one among the many prominent diseases of the modern world and millions of people are suffering due to the lack of proper medication. Even though transdermal drug delivery systems (TDDS) provide an efficient route of drug administration, the advantages of combination chemotherapy has rarely been extended into TDDS. In the present work...
Article
Cancer continues to be a serious disaster to mankind. Chemotherapy is an efficient and effective treatment against cancer. Lack of selectivity is the main challenge faced by chemotherapy. In present study we used folic acid (FA) as a targeting ligand, which selectively targets the cancer cell lines with over expressed folate receptors (FR). We graf...
Article
A novel magnetic molecularly imprinted polymer (MMIP) for the preconcentration of melamine, a non-protein nitrogen food additive from complex matrices was synthesized and characterized using FT-IR, XRD, SEM and VSM techniques. Surface imprinting was done on vinyltrimethoxysilane coated Fe3O4 (Fe3O4-VTMS) using 2-acrylamido-2-methylpropane sulfonic...
Article
Chemically modified graphene oxide (CMGO)/nanohydroxy apatite (nHA) composite was synthesized via a facile chemical modification of graphene oxide (GO) by triethyltetramine (TETA). Band gap of GO could be tuned for photo degradation under visible light through surface modification as well as by the composite formation with nHA. Pseudo-second-order...
Article
Polyacrylic acid-grafted-carboxylic graphene/titanium nanotube (PAA-g-CGR/TNT) composite was synthesized. It was effectively used as adsorbent as well as photocatalyst. The composite was characterized by FTIR, XRD, SEM, TEM, Surface Area Analyzer, XPS and DRS. The photocatalytic activity of PAA-g-CGR/TNT composite was evaluated on the basis of the...
Article
of this study is to report the synthetic procedure of a novel photo catalyst, nano zinc oxide incorporated graphene oxide/ nanocellulose (ZnO-GO/NC) for the effective adsorption and subsequent photo degradation of ciprofloxacin (CF), an antibiotic widely used in the poultry. Self cleaning property in cellulose was achieved by introducing a nano zin...
Article
An extended wear therapeutic contact lens (TCL) for the sustained delivery of timolol maleate (TML) was fabricated based on molecular imprinting technique. The designed TCL comprised of a TML imprinted copolymer of carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-polyacrylamide (CmCS-g-HEMA-g-pAAm) embedded onto a poly HEMA matrix (pHEMA). Suc...
Article
A novel efficient transdermal (TD) lidocaine (LD) delivery device based on chitosan (CS) and hyaluronic acid (HA) was successfully developed in the present investigation. CS was grafted with glycidyl methacrylate (GMA) and butyl methacrylate (BMA) to fabricate a versatile material with improved adhesion and mechanical properties. HA was hydrophobic...
Article
Inconsistent dosage of insulin (INS) for type 2 diabetes patients lead to severe adverse effects like limb amputation, blindness and fatal hypo or hyper glycaemia. Hence, a drug delivery system (DDS) capable of consistent INS release by sensing changes in blood glucose level is essential. Herein, we report a glucose responsive DDS comprised of olei...
Article
The principle aim of the present study is to synthesis a novel mesoporous silica-based dual drug delivery system (DDDS) with unique features for the delivery of amoxicillin (antibiotic) and thiamine hydrochloride (vitamin). The DDDS was characterized by Fourier transform infrared, X ray diffraction, differential scanning calorimetry, scanning elect...
Article
Curcumin (Cur), a poly phenolic yellow colored compound present in Indian spice turmeric, has wide variety of biological properties. Bioavailability of Cur is limited by its low water solubility, rapid metabolism and low stability. In the present study, we mainly focus on synthesis and characterization of dextran based nano-sized drug carrier (GHDx...
Article
The present work describes a novel method for the synthesis of silver polymer nanocomposite for the delivery of amoxicillin (AMO). Silver nanoparticles (AgNPs) were synthesized with chitosan and silver nitrate. The reaction parameters were optimized. Three-dimensional polymeric networks were synthesized by simple free-radical graft copolymerization...
Article
In the present work, we present a system of hydrogel/micelle composite as dual-drug release vehicle. The hydrogel is prepared from poly(ethyleneglycol) PEG and poly(vinyl alcohol) PVA. Polymeric micelles are enjoying high resurgence of interest in biomedical field as promising candidates for the stabilization and delivery of water insoluble drugs....
Article
A novel adsorbent, poly (itaconic acid/ methacrylic acid)-grafted-nanocellulose/nanobentonite composite [P(IA/MAA)-g-NC/NB] with multi carboxyl functional groups for the effective removal of Cobalt(II) [Co(II)] from aqueous solutions. The adsorbent was characterized using FTIR, XRD, SEM-EDS, AFM and potentiometric titrations before and after adsorp...
Article
Polymeric micelles are enjoying high resurgence of interest in biomedical field as promising candidates for the delivery of water-insoluble drugs. This property was used to design and synthesize fatty acid grafted polysaccharide-based copolymer micelles for the sustained release of Cefixime trihydrate (CFX): a third-generation cephalosporin. Chitos...
Article
A novel adsorbent, poly(ethyleneimine)-modified poly(acrylic acid)-grafted nanocellulose/nanobentonite superabsorbent hydrogel (PEI-PAA-g-NC/NB) was prepared by free radical graft copolymerization technique and well characterized. Swelling behavior of adsorbent was studied under different pH and temperatures. The various adsorption parameters for t...
Article
The performance of hexadecyltrimethylammonium chloride (HDTMA)-intercalated bentonite clay (organoclay) for the removal of acid red (AR) from aqueous solutions has been evaluated in this study. The adsorbent HDTMA-modified bentonite clay was prepared by the reaction of Na-bentonite with (HDTMA(+)) cations equal to twice the cation exchange capacity...
Article
Full-text available
The aim of the present work was to test the use of a surface modified multi-walled carbon nanotube based molecularly imprinted polymer (MWCNT-MIP) for the selective identification of monosodium glutamate (MSG) in food samples. The hydroxylated MWCNTs were reacted with allyl bromide to form vinylated MWCNTs (MWCNT-CH=CH2). The MWCNT-MIP was synthesi...
Article
The present investigation concerns the development and evaluation of a novel drug delivery system, aminated-glycidylmethacrylate grafted cellulose-grafted polymethacrylic acid-succinyl cyclodextrin (Cell-g-(GMA/en)-PMA-SCD) for the controlled release of 5-Fluorouracil, an anticancer drug. The prepared drug carrier was characterized by FT-IR, XRD an...
Article
Full-text available
The present study describes the feasibility of a novel adsorbent cum photocatalyst, poly(pyrrole-co-aniline)-coated TiO 2 /nanocellulose composite (P(Py-co-An)-TiO 2 /NCC), to remove eosin yellow (EY) from aqueous solutions. The removal of EY was investigated by batch adsorption followed by photocatalysis. The effect of various adsorption parameter...
Article
Full-text available
The removal of tetracycline hydrochloride (TCH) from aqueous solutions with a novel photocatalyst, polypyrrole coated iron-doped titania polymerised with itaconic acid [poly(IA)-(Fe-TiO2-PPy)] was investigated in a batch system. All the prepared samples were characterized using scanning electron microscopy (SEM), Transmission electron microscopy (T...
Article
A novel drug delivery system (DDS) was prepared by graft polymerization of chitosan coated magnetic nanoparticles (CS-MNP) with acrylic acid and grafted with ethylenediamine derivative of β-cyclodextrin (β-CD) for the sustained and controlled release of anticancer drug, curcumin (CUR). The DDS was characterized by means of SEM, TEM, DLS, FT-IR, XRD...
Article
In this study, the removal of Pb(II) ion from aqueous solutions by glutaraldehyde-cross-linked epoxyaminated chitosan (GA-C-ENCS) was investigated. The adsorbent (GA-C-ENCS) was characterized by FTIR, SEM–EDS, X-ray photoelectron spectroscopy, and potentiometric titration. Equilibrium sorption experiments were carried out at different operational c...
Article
In the present study, a cellulose based adsorbent, P(MB-IA)-g-MNCC was synthesized by graft co-polymerization of itaconic acid onto MNCC using EGDMA as crosslinking agent and K2S2O8 as free radical initiator. P(MB-IA)-g-MNCC was characterized by FTIR, XRD, SEM, TG and VSM. Cd(II) adsorption occurs maximum at pH 6.0. Kinetic and isotherm data were d...
Article
The present study reveals a new method of preparation of an adsorbent, poly(itaconicacid)-poly(methacrylicacid)-grafted-nanocellulose/nanobentonite composite (P(IA/MAA)-g-NC/NB), using cellulose extracted from cotton for the effective removal of Uranium(VI), [(U(VI)] from aqueous solutions. The adsorbent was synthesized by graft copolymerization re...
Article
Polymeric materials have been used for wide range of applications in the modern medicine, as much of them are biocompatible with blood, tissues, cells and in the human body. In the present work, we prepared thiolated chitosan (TCS) immobilized–amino acid intercalated montmorillonite (AM-MMT) as a drug carrier vehicle for the controlled release of t...
Article
A novel composite matrix polymethacrylic acid-grafted Chitosan/Bentonite (PMAA-g-CS/B) was prepared through graft copolymerization reaction of methacrylic acid and chitosan in the presence of bentonite and N, N'-methylene-bisacrylamide as cross linker. The composite was well characterized using FTIR, XPS, SEM, TG/DTG, surface area analyzer and pote...
Article
A novel adsorbent, 2-mercaptobenzamide modified itaconic acid-grafted-magnetite nanocellulose composite [P(MB-IA)-g-MNCC] was synthesized for adsorbing mercury(II) [Hg(II)] ions selectively from aqueous solutions. Fourier transforms infrared spectroscopy, X-ray diffraction, scanning electron microscopy and thermogravimetric studies were performed t...
Article
The concept of novel drug delivery systems aims at achieving systematically improved therapeutic success for drugs including those that have limited use because of toxicity, uneven distribution pattern, stability and formulation of difficulties. The paper reveals the potential uses of novel hybrids of oleic acid-g-chitosan and montmorillonite (OA-g...
Chapter
Stimuli-sensitive polymers are very promising and versatile materials for biomedical applications, especially in controlled drug delivery systems (DDS). Controlled DDS provide a therapeutical quality of medicines to the proper site in the body in order to achieve the desired effect with minimum toxicity. DDS are promising in diseases like asthma, c...
Article
A novel drug delivery system (DDS), 3-methacryloxypropyl trimethoxy silane coated magnetic nanoparticles polymerized with glycidylmethacrylate-grafted-maleated cyclodextrin (MPTMS-MNP-poly-(GMA-g-MACD)) was prepared in the presence of ethyleneglycoldimethacrylate as cross-linker and a,a'-azobisisobutyronitrile as initiator and characterized by mean...
Article
Cationic surfactant (Hexadecyltrimenthylammonium chloride) modified bentonite clay was prepared and systematically studied its adsorption behavior as an efficient adsorbent for the removal of basic dyes such as Methylene Blue (MB), Crystal violet (CV) and Rhodamine B (RB) from aqueous phase. Organo modified clay shows better capacity for the remova...
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Full-text available
Gene therapy is a new kind of medicine, which uses genes as drugs in order to treat life threatening diseases. In the present work, a nonviral vector, aminated β-cyclodextrin-modified-carboxylated magnetic cobalt/nanocellulose composite (ACDC-Co/NCC), was synthesized for efficient transfection of genes into tumour cells. The synthesized ACDC-Co/NCC...
Article
Novel photocatalyst, poly(itaconic acid-co-2-acrylamido-2-methylpropane-1-sulfonic acid) iron doped titania/silane was successfully prepared by the polymerization of iron doped titania/silane and two functional monomers, itaconic acid and 2-acrylamido-2-methylpropane-1-sulfonic acid in aqueous solution using ethylene glycol dimethacrylate as cross-...
Article
Polysaccharides extracted and isolated from plant products serve as potential candidates in pharmaceutics mainly drug delivery, owing to its biodegradability, bioavailability and non-toxic character. Hydrogels, three-dimensional hydrophilic polymeric networks, exhibit dramatic changes in their swelling behaviour, network structure, and mechanical s...
Article
A novel potentiometric sensor with high selectivity in addition to sensitivity was developed for the determination of lindane, γ-hexachlorocyclohexane (γ-HCCH), based on the modification of γ-HCCH imprinted polymer film onto the surface of Cu electrode. A multiwalled carbon nanotube (MWCNT) was grafted using glycidyl methacrylate (GMA). The reactio...
Article
Superabsorbent polymer composites (SAPCs) are very promising and versatile materials for biomedical applications. This study concentrates on the development of novel cellulose-based SAPC, Poly(acrylic acid-co-acrylamide-co−2-acrylamido-2-methyl-1-propanesulfonic acid)-grafted nanocellulose/poly(vinyl alcohol) composite, P(AA-co-AAm-co-AMPS)-g-NC/PV...
Article
A novel silane based adsorbent material, [stearyl alcohol (SA)-grafted-epichlorohydrin (E)]-grafted-aminoproypyl silanetriol (APST) was synthesized and functionalized with sulfonic acid [(SA-g-E)-g-APST/SO3H]. The adsorbent material was characterized by FTIR, XRD, SEM and BET analysis. Protein-particle interaction was studied by the immobilization...
Article
In recent years, a major class of drug delivery vehicles that has received attention is represented by layered materials, which can intercalate therapeutic compounds between their layers. They can be used as delivery matrices, as the release of drugs from intercalated layered materials is potentially controllable. The purpose of the current study f...
Article
novel potentiometric sensor based on ion imprinted polymer inclusion membrane (IPIM) was prepared from the modification of multiwalled carbon nanotube (MWCNT) based molecularly imprinted polymer for the trace determination of the pesticide 2,4-D (2,4-dichlorophenoxyacetic acid) in natural water samples. MWCNTs are initially functionalized with viny...
Article
In this study, removal of mercury(II) ions from aqueous solutions under different experimental conditions using formaldehyde polymerized banana stem (FPBS) has been investigated. Formaldehyde treatment favored the stabilization of the organic substances of banana stem (BS). The adsorbent was characterized using IR, SEM, TG, and potentiometric titra...
Article
A novel Semi-Interpenetrating Polymer network (IPN) based on Crosslinked carboxymethyl starch (CL-CMS) and Montmorillonite (MMT) was prepared, where carboxymethylation occurs as a result of the reaction between native starch and monochloroacetic acid in isopropanol/water medium at 60°C. The carboxymethyl starch is further crosslinked and made into...
Article
The principle aspiration is to develop a core shell carrier system for 5-Fluorouracil. Trisodiumcitrate crosslinked chitosan containing 5-Fluorouracil coated with cellulose acetate acts as core and copolymer of N-vinyl-2-pyrrolidone, 2-hydroxyethylmethacrylate, and itaconic acid act as shell. SEM, FTIR, and XRD studies were undertaken to characteri...