T.C.K. Brown's research while affiliated with The Royal Melbourne Hospital and other places

Publications (29)

Article
The polio epidemic in Copenhagen in 1952 was a significant stimulus to the development of Intensive Care. Eighty-five percent of the patients with respiratory involvement died despite the use of Cuirass negative pressure ventilators. After some controversy Ibsen, an anesthetist, was consulted. He found that many patients were dying with CO(2) reten...
Article
The physiological application of OHMS LAW explains the basis of hypotensive anesthesia. V = IR translates into: Pressure = Flow × Resistance or Blood pressure = Cardiac Output × Peripheral Resistance. If peripheral resistance is reduced by a vasodilator such as sodium nitroprusside (a short acting, vascular smooth muscle relaxant) or phenoxybenzami...
Article
Coaxial tomography (CT) and magnetic resonance imaging (MRI) scans are so much part of neurological investigation these days and provide such detailed information that even thorough neurological clinical examination may be neglected. The investigations in common use forty years ago were pneumoencephalography, ventriculography in babies with hydroce...
Article
John Inkster died on September 10th 2011. He started life early, weighing only 2 pounds (0.9 kg). The outlook for him and his twin sister was poor so his mother, who was a nurse trained at the Childrens Hospital, Great Ormond Street, took them home to look after them herself. This showed that very small premature babies could survive with special c...
Article
In 1984, David Steward (in Figure 1, front row) and Seizo Iwai (Figure 2) organized a meeting of pediatric anesthetists in Manila during the World Congress of Anesthesiologists. Following the meeting, there was a dinner at which John Zorab, then Secretary of the World Federation of Societies of Anaesthesiologists (WFSA), told the audience that if t...
Article
Fifty years ago, a baby born at 24-26 weeks was not considered viable. It was a tragedy for the mother having carried it for so long. I witnessed such an event as a student. The scourge of premature deliveries was the lack of surfactant in many tiny babies. In general, if a premature infant with hyaline membrane disease, as it was called respirator...
Article
Digby Leigh was a pioneer of Canadian pediatric anesthesia. He was an outstanding man - once met, never forgotten. My only contact with him was at the First Paediatric Anaesthesia Workshop at HSC in Toronto organized by Alan Conn in 1964. He chaired a panel with Jackson Rees from Liverpool and Bob Cope, a gentlemanly senior anesthetist at the Hospi...
Article
The history of local and regional anesthesia began with the discovery of the local anesthetic properties of cocaine in 1884. Shortly afterwards nerve blocks were being attempted for surgical anesthesia. Bier introduced spinal anesthesia in 1898, two of his first six patients being children. Spinal anesthesia became more widely used with the advent...

Citations

... With great fortitude and the help of splendid assistants, Helene Wood, Mary Dwyer, Kester Brown, and others, he held both departments together till his tragic early death in 1974 from complications of cancer surgery. 19 Twenty-five years after his passing, John Stocks was commemorated for his exceptional contributions to paediatric care in Australasia. 20 Kester Brown succeeded John Stocks as the next director of RCH Department of Anaesthesia , leading the department into the new millennium. ...
... In case 4, however, even doubling minute volume could hardly correct the hypercapnia and it is exactly this inappropriateness that points at hypermetabolism and a possible MH crisis. Therefore, we entirely agree with the dictum by Brown that "the most useful clinical sign of MH is an end-tidal CO 2 that continues to rise despite increasing ventilation" 28 . ...
... In order to paralyze prey they would dip the tips of their arrows into a dark, tarry liquid which contained an unknown compound that would result in paralysis [Keesey 2002]. The first documented account of the use of these paralyzing poisoned arrows was recorded in 1516 by Peter Martyr D'Anghera when describing use of these arrows by hunters in South America [Brown 2013]. This compound was later identified as curare [Keesey 2002;Brown 2013;Murphy et al., 2020;Scheindlin 2010]. ...
... Kalow (1957) describe que la duración de acción dependía de la colinesterasa plasmática. Se continuó estudiando y aparecieron los efectos adversos: bradicardia (por su actividad parasimpática en corazón), 19 aumento de la presión intragástrica (1962), mialgias (1954), liberación de potasio (1954) e histamina (1957). ...
... [8] The use of controlled hypotension in pediatric surgery was first reported in 1953; thereafter, widely used in various pediatric surgical procedures, including scoliosis surgery, vascular surgery, and neurosurgery. [5] Although the use of dexmedetomidine was limited in pediatrics, several studies had used it with clinically acceptable results as regards intraoperative HR and MAP in pediatric age group. [13,14] El Saied et al. found that dexmedetomidine infusion in cochlear implantation in pediatric patients was better in inducing deliberate hypotension and providing better quality scale of surgical field compared to fentanyl infusion. ...
... While no formal evaluations of quality exist, they are proving remarkably accurate in determining cerebral anatomy for instance [46]. While such imaging results are obviously inferior to those produced by newer 64 or 128 slice CT scanners they would for instance still greatly improve upon the performance of ''blind'' craniectomies or those directed by physical exam [47]. ...
... There were many problems to be solved and lessons to be learnt. [9] A tube passed through the nose bypassed the normal humidifying function of the nose. Consequently secretions in the airway dried and caused obstruction. ...
... Mit der vorliegenden Arbeit konnte gezeigt werden, dass eine Leckage bei nasaler Hochfre- 10 7,5 7,6 8,0 8,5 7,2 6,6 6,0 5,5 10,1 9,6 9,7 9,5 10,4 9,8 9,8 9,7 2 10 7,3 7,5 8,0 8,5 6,9 6,5 5,5 5,4 9,7 9,5 9,5 9,5 10,0 9,7 9,7 9,7 3 10 7,3 7,6 8,1 8,5 6,9 6,5 5,6 5,4 9,8 9,5 9,4 9,5 10,1 9,7 9,6 9,7 4 10 7,5 7,7 8,1 8,7 7,1 6,6 5,7 5,5 10,3 9,7 9,8 10,1 10,2 9,6 9,7 10,0 5 10 10,5 11,1 11,6 12,2 7,4 7,6 8,1 8,6 7,0 6,5 5,7 5,7 10,6 10,1 10,2 10,3 10,3 9,7 9,8 9,9 10,3 9,7 9,7 9,9 ...
... Recibido: 04/08/2020 Aprobado: 28/09/2020 Introducción Las técnicas de anestesia y analgesia regional en la población pediátrica son conocidas desde 1899; sin embargo, su utilización frecuente es reciente al demostrarse la facilidad de realización de los bloqueos, así como la estabilidad hemodinámica y respiratoria que producen. (1) Desde el primer reporte médico pediátrico en 1933, el uso de la anestesia caudal se ha incrementado enormemente, de manera particular para cirugías de abdomen inferior. Varios estudios describen la importancia de esta técnica, sus indicaciones, el nivel de analgesia, las dosis recomendadas y la farmacocinética de los anestésicos locales usados, además de las ventajas y desventajas específicas y generales. ...