T. Wu's scientific contributions

Publications (10)

Article
Clinical research reports are the main form of clinical evidence. Based on the requirements of clinical research reports and the characteristics of clinical research on traditional Chinese medicine, it is an important basic systematic project to construct a standardized system of clinical curative effects study report on Chinese medicine. This arti...
Article
Clinical trial transparency, include clinical trial registration, unbiased reporting results and sharing individual participant data (IPD), is one of the most important revolutionary concepts following clinical epidemiology and evidence-based medicine in the medical field. Sharing IPD is a medical ethics issue reflected a new sense of worth and con...
Article
Data management system is a major factor affecting the quality of clinical trial. Development of data management system include a steering group and data safety and monitoring board, data collection, database, performance of the data safety and monitoring, as well as locking of database. This article provides key issues of the five parts so as to h...
Article
Objectives To explore potential important factors that impacts the quality of Chinese trials. Methods We randomly selected clinical studies registered in the Chinese Clinical Trial Registry during March 15th, 2016 to December 31st, 2016. The randomized controlled trials protocols were retrieved to assess the quality based on the SPIRIT guideline, t...
Article
Since the public clinical trial registration system was launched twelve years ago in China, as the primary register of the WHO International Clinical Trial Registry, the Chinese Clinical Trial Registry (ChiCTR) has largely promoted the development of clinical trial registration in China, particularly in recent three years. The quantity of registere...
Article
In recent years, CRO has developed rapidly in China, and has played an important role in improving the level of Chinese clinical trials and drug development. However, the development of CRO industry also has problems. This paper discusses the beneficial factors of the main problems and the future direction of CRO, in attempt to attract the attentio...
Article
The quality of clinical trials is key to determine the value of a clinical research and whether it can transform achievements. In this paper, the characteristics and direction of the implementation of quality control in clinical trials in China, and the characteristics of quality control in clinical trials of Chinese medicine are discussed, and the...
Article
This paper introduces the development and changes of clinical practice guidelines based on the enlightenment of the Reporting Items for Practice Guidelines in Health Care (RIGHT), and provides policy recommendations. © 2018, West China University of Medical Science. All rights reserved.
Article
Ethical issues in clinical research are receiving increasing attention. The application of research projects, the registration of clinical trials and the publication of scientific researches have always been involved with ethical issues. This paper elaborates ethical development and changes in Chinese clinical research from the aspects of the devel...

Citations

... Clinical trials are studies based on population, human body, or samples, such as tissues and fluids [1]. Evidence from clinical trials provides a meaningful reference for doctors and policymakers in health care [2]. ...
... Other items, including baseline data (item 15), ancillary analyses (item 18), harms (item 19), limitations (item 20), registration (item 23), protocol (item 24), and funding (item 25) in the "Results" and "Other information" sections, were also reported poorly. Inadequate reporting of trial registration, protocol, and ethical approval significantly compromises the value of massage RCTs, inviting skepticism and criticism [28]. At the same time, we identified a considerable number of NPT Extension items that were missing or incompletely reported; the average reporting rate was only 10%, with a range of 0.04% to 57%. ...
... Traditional Chinese Medicine (TCM) therapies have been used in China for centuries and have attracted increasing attention in the world, yet lack of reliable evidence on its effectiveness and safety could be one of the impediments for its wider application. Although more and more TCM researchers acknowledge the importance of clinical trials [1,2], methodological appraisals and systematic reviews on the published TCM clinical trials suggest poor methodological and reporting quality [1,3,4], pointing out the need for quality improvement. TCM clinical trials discussed in this study are clinical experiments intended to evaluate the efficacy/effectiveness and/or safety of interventions (medicinal or nonpharmacologic) based on TCM theories. ...
... It could be necessary to develop a reporting checklist for TCM trial registrations, as an extension of the WHO TRDS, which will beneficial to improve the quality of TCM trial registrations. Before starting the development, our working group members (ZB and TW) have introduced the rationale for establishing the guideline of TCM trial registration in workshops and academic conferences to solicit comments, as well as relevant articles have also been published [19,20]. In addition, we consulted with professionals from the WHO International Clinical Trials Registry Platform (ICTRP) and the Chinese Clinical Trial Registry and promoted the significance of developing this extension. ...
... Besides, researchers may estimate standardization, accuracy, and completeness of the trial implementation process based on a registered protocol. 29,30 The past few years have witnessed an increase in the number of registrations, but merely 2 (4.55%) articles mentioned, and none reported specific access to full trial protocol. This may reflect the lack of awareness among researchers in the registration of trials on AT for COPD. ...
... It was obviously lower than the proportion of 86% revealed by a survey, which randomly sampled 457 studies registered in 2016 on ChiCTR and downloaded the research plan for analysis. 42 Although the researchers are willing to share the original data of their research, the accessibility of participant-level data is still a challenge. 42 Only 28% of the studies described a correct data management system, and 67% of the researchers may not know that clinical studies should adopt professional and standard data management systems to manage their data. ...