T Weinke's research while affiliated with Ernst von Bergmann Klinikum Potsdam and other places

Publications (65)

Article
Die Reisediarrhö ist die häufigste Krankheit des Fernreisenden und kommt bei 10–50 % dieser Zielgruppe vor. Bei gut 90 % der Diarrhöepisoden klingen die Beschwerden innerhalb von 3 bis 5 Tagen ohne Komplikationen ab. Es ist jedoch wichtig, komplikationsträchtige Verläufe zu erfassen und rasch zu therapieren. Enterotoxinbildende E.-coli-Stämme (ETEC...
Article
Travelers diarrhea affects millions of tourists each year. Most cases are caused by a variety of bacterial enteropathogens: toxigenic Escherichia coli, Campylobacter, Shigella, Salmonella, Aeromonas, Plesiomonas and non-cholera vibrios. Treatment may include antibacterial therapy with either ciprofloxacin, or azitrhomycin, or rifaximin. Viral patho...
Article
Neuroendocrine tumors (NET) of the stomach are on the rise. In the United States they have increased about tenfold in the last 35 years. Prognosis has been much improved over the last three to four decades. Nowadays most of such NETs are diagnosed at an early stage. Quite often gastric NETs are found incidentally during a gastroscopy, performed for...
Article
Neuroendokrine Tumoren (NET) des Magens sind auf dem Vormarsch: in den USA haben sie in den letzten 35 Jahren um ca. 1000 % an Häufigkeit zugenommen. Zeitgleich hat sich aber die Prognose der Patienten wesentlich verbessert, da die Mehrzahl dieser Tumoren heutzutage in einem frühen Stadium festgestellt wird. Nicht selten erfolgt die Diagnose „en pa...
Article
More than 10,000 people die each year from pneumococcal disease. The incidence depends on various risk factors, such as age and immunocompetence. The drug of choice in the treatment of pneumococcal infections is penicillin. However, increasing antibiotic resistances must be considered when using this therapy. Vaccination against pneumococcal diseas...
Article
Seasonal influenza causes yearly increased morbidity and mortality especially in older adults and patients with a comorbidity. Vaccination coverage in Germany reaches 60 % in the age group of persons over 60 years, but fails to reach the WHO target of 75 %. Improved immunogenicity of vaccines is necessary because of the occurrence of immunosenescen...
Article
Die saisonale Influenza führt jährlich zu erhöhter Morbidität und Mortalität, insbesondere bei älteren Personen und bestehenden Begleiterkrankungen. Die Durchimpfungsraten in Deutschland mit 60 % bei den über 60-Jährigen erreichen nicht die WHO-Zielkriterien von 75 %. Aufgrund des immunologischen Alterungsprozesses ist eine verbesserte Immunogenitä...
Article
Traveller's diarrhoea (TD) constitutes the most common disease relevant to travel medicine with ETEC as the leading causative pathogen. Cholera is the most serious, but very rare form of TD. ETEC and cholera share pathogenic mechanisms by producing a toxin that has an 80% amino acid homology. A consensus of German-speaking experts sees the indicati...
Article
Die Reisediarrhoe ist die häufigste Erkrankung bei Fernreisen und wird besonders durch Enterotoxin-bildende Escherichia coli-Stämme (ETEC) hervorgerufen. Die Cholera kommt in einigen tropischen Gebieten endemisch vor, bei Reisenden stellt sie jedoch nur ein marginales Problem dar. Der Pathomechanismus von ETEC ist dem von V. cholerae vergleichbar:...
Article
Leishmaniasis is a rare, non-notifiable disease in Germany. Epidemiological and clinical data, therefore, are scarce. Most infections seen in Germany are contracted outside the country. The German surveillance network for imported infectious diseases (Surveillance Importierter Infektionen in Deutschland, or SIPMID) recorded 42 cases of imported lei...
Article
Acute travellers' diarrhoea usually starts a few days after arrival in the travel destination and resolves after 3-5 days. The most common pathogens in the acute form are ETECs, salmonella, campylobacter, and shigella. Chronic travellers' diarrhoea, which persists for more than 10-14 days is often associated with parasitic causes, like Giardia lamb...
Article
This is a case report of a 45-year-old woman who presented herself in our hospital with increasing retrosternal tenderness to pressure, dysphagia, and symptoms of reflux oesophagitis. The clinical examination and laboratory results showed no pathological findings. Oesophagogastroduodenoscopy revealed a bluish-livid, bulging mass from 32-38 cm abora...
Article
A 51-year-old asthenic patient attended the hospital with syncope, head injury, tarry stool and severe anemia. There was a history of alcohol and nicotine abuse, but no known preceding diseases of the liver or gastrointestinal tract. Except hypotension, examination of the patient did not show any further abnormalities. DIAGNOSTIC PROCEDURE: An uppe...
Article
Inflammatory bowel disease (IBD) encompasses two forms of intestinal inflammation: ulcerative colitis and Crohn's disease. The cause of these major forms of IBD are unknown. Many other inflammatory disorders affect the gastrointestinal tract and should be excluded. The diagnostic steps and clinical features are discussed. It is often difficult to d...
Article
Extra-intestinal symptoms and findings are often related to chronic intestinal diseases namely; ulcerative colitis and Crohn's disease, whose clinical pictures are differently influenced. Principle differences may be drawn between the manifestation of extra-intestinal inflammation and extra-intestinal complications. Difficulties between the two occ...
Article
Severe to mild development of Crohn's disease requires an intermittent therapy with steroids in combination with 5-aminosalicylic acid as the standard therapy. Severe disease development and steroid dependence should be treated with azathioprine as early as possible. Methotrexate (MTX) is supposed to be used as reserve medication. Other immunosuppr...
Article
The case described concerns a 68-year-old male patient, who received intravesical BCG instillations for non-resectable urothelial carcinoma (stage pT1, G2). After the third instillation, which was complicated by hematuria during catheterization, he had a high temperature, dyspnoea, a weight-loss of 15 kg and critical recurrent hypotension for 3 wee...
Article
A survey was conducted among Latin American immigrants living in Berlin to investigate the presence of Trypanosoma cruzi infection and to evaluate possible risk factors. One hundred persons were interviewed about risk factors (rural origin, contact with the reduviid bug) and evaluated serologically. The sera were tested with indirect immunofluoresc...
Article
To examine the prevalence of stool viruses and their role in the pathogenesis of diarrhea in HIV infection, we evaluated biopsies and repeated stool samples of 256 HIV-infected patients undergoing diagnostic endoscopy because of diarrhea (n = 136) or other symptoms (n = 120) for bacterial, protozoal, and viral enteropathogens. In 70% of the patient...
Article
The DOT-STRIP-ELISA was evaluated in the laboratory as a serodiagnostic tool for Schistosoma haematobium infection in order to assess the potential of introducing the technique under field conditions in the developing world. Out of 100 individuals with parasitologically confirmed Schistosoma haematobium, 87 reacted positively (sensitivity 87%), whe...
Article
Travellers to malarious areas are increasingly advised to carry an emergency medication for self-treatment of suspected malaria in absence of medical attention. However, no data are available so far how travellers cope with self-diagnosis and stand by treatment (SBT). We therefore investigated the frequency, circumstances and outcome of emergency s...
Article
Malaria chemoprophylaxis does not rely on causal aspects but is based on suppression of clinical symptoms after infection has taken place. Chloroquine remains the standard for infection against the "benign" forms of malaria. Due to the widespread chloroquine-resistance of Plasmodium falciparum a chemoprophylaxis will consist of mefloquine or chloro...
Article
Full-text available
The diagnostic yields of stool cultures and biopsy specimens for the detection of enteric bacterial pathogens in 213 human immunodeficiency virus-infected patients were compared. Forty-five percent (19 of 42) of the pathogens were detected exclusively by stool culture, 2% (1 of 42) of the isolates were detected exclusively by culture of biopsy spec...
Article
Full-text available
To investigate behaviour in the use of drug prophylaxis against malaria and the risk factors for non-compliance, 507 European or North American travelers returning from endemic areas were studied retrospectively at Berlin in a 11-year period from 1980 to 1990. Compliance was significantly correlated with shorter travel duration: the group with good...
Chapter
Eines der häufigsten klinischen Probleme bei HIV-infizierten Patienten ist die akute oder chronische Diarrhö; es wurde berichtet, daß in entwickelten Ländern 18–50% der Aids-Patienten über eine Durchfallsproblematik klagen [22, 34, 37, 44], während es in Entwicklungsländern bis zu 90% sein können [28]. In vielen Fällen werden in Zusammehang mit der...
Article
The prevalence of enteropathogenic bacteria over a three-year period was 3.1% in an urban population in Germany. Nontyphoidal Salmonella spp. (1.8% prevalence) represented 59.3% of all positive isolates, followed by Campylobacter spp., which constituted 22.1% of such isolates. Clostridium difficile toxin was detected in 5.6% of samples submitted sp...
Article
The efficacy (criteria: cure rate, time to resolution of fever or absence of parasites) and safety (criteria: clinical side effects, altered laboratory parameters) of halofantrin were investigated in a multi-centre study of 96 non-immune patients (71 men, 25 women, mean age 34.3 [21-62] years) with malaria imported from regions of high resistance i...
Article
Full-text available
Im Rahmen einer prospektiven Multizenterstudie wurden die Wirksamkeit (Kriterien: Heilungsrate, Zeit bis zur Entfieberung oder Parasitenfreiheit) und Verträglichkeit (Kriterien: klinische Nebenwirkungen, veränderte Laborparameter) von Halofantrin bei 96 nicht-immunen Malaria-Patienten (71 Männer, 25 Frauen, mittleres Alter 34,3 [21-62] Jahre) unter...
Article
In an attempt to identify risk factors for Staphylococcus aureus septicemia, 136 consecutive HIV-infected patients were investigated for the presence of nasopharyngeal colonization with Staphylococcus aureus and subsequent Staphylococcus aureus infection. Sixty of 136 (44.1%) HIV-infected patients had staphylococci which were detected in the nasoph...
Article
Bacterial infections of the gastrointestinal tract are found in 13-40% of HIV-infected patients with gastrointestinal symptoms. In general, these infections show a tendency to bacteraemia, persistence and relapses despite antibiotic therapy which is probably the result of the underlying immunodeficiency. Mycobacterium avium complex is the most freq...
Article
Full-text available
The therapeutic effects and side effects of mefloquine in falciparum malaria were investigated in an open prospective trial involving 20 patients. None of them had a history of neurologic or psychiatric disorders. Mefloquine was given in a total dose of 1500 mg base. The cure rate was 100%, fever and parasitemia subsided within 3 days. Side effects...
Article
Amebic colitis and amebic liver abscess were diagnosed in a 45-year-old patient who had returned from Thailand. Ultrasound scans performed after starting treatment with metronidazole showed an abscess located above the right kidney that had enlarged to a maximum diameter of 9.7 cm. Since rupture of this lesion was felt to be imminent, ultrasound-gu...
Article
This is a case report of a 24 year-old woman who is HIV-infected since three years (stage III B, CDC). She developed malaria tropica during her touristic stay in the Cameroons, Africa. No clinical complications were detectable even though she had a high parasitemia of 18% blood cells infected with Plasmodium falciparum. After quinine therapy deferv...
Article
The clinical symptomatology of bacterial septicemias was analysed in 417 patients of a University Hospital in West Berlin. Sepsis was caused by Gram-negative organisms in 229 cases, and by Gram-positive bacteria in 177 cases; 11 cases presented with a mixed type sepsis involving both Gram-positive and Gram-negative pathogens. With the exception of...
Article
The clinical course and response to therapy of seven patients with cryptococcosis and AIDS were reviewed. One patient was still in the primary stage of cryptococcosis in AIDS, i.e. the stage that is characterized by the sole cultural detection of Cryptococcus neoformans in the respiratory tract. The other six patients were in the secondary stage, w...
Article
Between 1980 and 1985 falciparum malaria was diagnosed in 28 and tertian malaria in 17 patients. Only three of the 35 non-immune patients complied with the appropriate chemoprophylaxis; these three patients nevertheless developed tertian malaria (recurrences caused by "dormant" merozoites). The main drawbacks of chemoprophylaxis were lack of patien...
Article
We report the case of a 56-year-old patient who first contracted pleuropericardial tuberculosis at the age of 19 years. 37 years later the patient again developed pericarditis. The diagnosis of tuberculous pericarditis was confirmed after a course of several months by bacteriological culture of pericardial fluid. In this case, magnetic resonance im...

Citations

... They should be considered as general diseases with multiple immune pathology. Because of this, clinicians are always interested not only in the local changes or complications of IBD associated immediately with an inflammation in the digestive tube but also abenteric or system manifestations of diseases [5][6][7][8][9][10][11]. ...
... Further prevalent serovars like S. Infantis and S. Derby represented <5 % of the reported cases [3]. Although in most cases salmonellosis is self-limiting, antibiotic treatment may be required for risk group patients and more severe disease, like bloodstream infections [4]. Antibiotics for treatment of salmonellosis comprise β-lactams, fluoroquinolones, macrolides, and trimethroprim-sulfamethoxazole [4]. ...
... [19, 20, 21]. Einige klinische Studien hingegen weisen eine protektive Wirkung für invasive Krankheitsverläufe auch im höheren Alter nach [22, 23] und lassen einen Nutzen auch für nichtinvasive Erkrankungen wie die nicht bakteriämisch verlaufende Pneumokokkenpneumonie vermuten [24, 25, 26]. In einer Metaanalyse [27] CME Gemäß einer Stellungnahme von Experten der Paul-Ehrlich-Gesellschaft (PEG) ist die sequenzielle Impfung zuerst mit PCV13, dann mit PPV23 der derzeitig wahrscheinlich beste erhältliche Impfschutz gegen Pneumokokken [34]. ...
... Most duodenal NETs are discovered at an early treatable stage (tumor diameter ≤10 mm) [69,70]. In the instances when tumors are associated with a syndrome, for example ZES, lesions are often metastatic [71]. ...
... BCG dissemination in the immunodeficiency state is well-documented, however, there are also studies reporting it in apparently healthy individuals [20]. Likewise, there are several reports of BCG dissemination with bone marrow involvement in those with impaired immune system [21,22]. ...
... Der Nachweis neuroendokriner Tumoren des Gastrointestinaltrakts hat in den letzten 3 Jahrzehnten deutlich an Häufigkeit zugenommen [38,39]. Sonografisch und endosonografisch haben sie typische Kriterien: kleine Tumoren liegen primär in der Submukosa und haben ein echoarm-granuläres Binnenmuster ("Pfeffer und Salz"). ...
... Insgesamt ist die Datenlage zum Nutzen der PPV23-Impfung kontrovers: Zahlreiche Studien sehen den Vorteil auf invasive Krankheitsverläufe beschränkt und bewerten ihn eingeschränkt für die Gruppe der chronisch Kranken und Älteren [2,10,13]. Einige klinische Studien hingegen weisen eine protektive Wirkung für invasive Krankheitsverläufe auch im höheren Alter nach [24,25] und lassen einen Nutzen auch für nichtinvasive Erkrankungen wie die nichtbakteriämisch verlaufende Pneumokokkenpneumonie vermuten [4,18,23] ...
... Also multiple previous hospital admission had 88.5% occurrence rate in this study. This is also supported by Chacko who reported that the colonization of individuals with HIV/AIDS by pathogenic microorganisms has been associated with higher risk of morbidity and mortality, principally when related to Staphylococcus aureus [23]. Researchers found a rate of 76.7% of colonization with this bacterium in this population, indicating prolonged hospitalization (over 10 days) as a risk factor for resistance to methicillin. ...
... However, mefloquine side effects were reported from different parts of the world (3,4) . The most common side effects reported were mild late neuropsychiatric disturbances (5,6) . Severe neuropsychiatry reactions due to mefloquine are rare (6) . ...