T Watanabe’s research while affiliated with Keio University and other places

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Publications (131)


4491837a
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February 2013

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36 Reads

K Asahi

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K Ichimori

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K Kurokawa
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Skin autofluorescence is associated with severity of vascular complications in Japanese patients with Type 2 diabetes

September 2011

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35 Reads

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60 Citations

Diabetic Medicine

Skin autofluorescence, a non-invasive measure of the accumulation for advanced glycation end products, has been reported to be a useful marker for diabetic vascular risks in the Caucasian population. The aim of this study was to evaluate associations between skin autofluorescence and vascular complications in non-Caucasian patients with Type 2 diabetes. Subjects in this cross-sectional study comprised 130 Japanese patients with Type 2 diabetes. Skin advanced glycation end products were assessed by skin autofluorescence using an autofluorescence reader. Association between skin autofluorescence and severity of vascular complications was evaluated. Of the 130 patients, 60 (46.2%) had microvascular complications such as diabetic retinopathy, neuropathy and nephropathy, 10 (7.7%) had macrovascular complications and 63 (48.5%) had micro- and/or macrovascular complications. Skin autofluorescence increased with severity of vascular complications. Independent determinants of skin autofluorescence were age (β = 0.24, P < 0.01), mean HbA(1c) in previous year (β = 0.17, P = 0.03), microvascular complications (β = 0.44, P < 0.01) and macrovascular complications (β = 0.27, P < 0.01). Multiple logistic regression analysis revealed that diabetes duration (odds ratio 1.15, P < 0.01), systolic blood pressure (odds ratio 1.04, P = 0.01), skin autofluorescence (odds ratio 3.62, P = 0.01) and serum albumin (odds ratio 0.84, P < 0.01) were independent factors for the presence of vascular complications in these patients. Skin autofluorescence had independent effects on vascular complications in Japanese patients with Type 2 diabetes. This indicates that skin advanced glycation end products are a surrogate marker for vascular risk and a non-invasive autofluorescence reader may be a useful tool to detect high-risk cases in non-Caucasian patients with diabetes.


Lower plasma arginine in enteral tube-fed patients with pressure ulcer and improved pressure ulcer healing after arginine supplementation by Arginaid Water

April 2011

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105 Reads

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21 Citations

The Journal of Nutrition Health and Aging

To determine the presence or extent of arginine deficiency in pressure ulcer (PU) patients on percutaneous endoscopic gastrostomy (PEG) feeding and to examine the effects of arginine supplementation on PU healing. All eligible PEG patients, with and without PU, were cross-sectionally assessed for plasma arginine. Three-month supplementation with arginine-enriched water (Arginaid Water) was performed on a subset of patients with PU. This intervention study was a prospective, non-controlled trial with 5 PU patients. Geriatric ward of a rural clinical hospital in Japan. Thirty-nine inpatients with PEG feeding were assessed for plasma arginine. Five of the 13 patients with PU and five of 26 patients without PU underwent amino acid profiling. Five of the patients with PU received Arginaid Water supplementation. Plasma amino acid measurements and biochemical analyses were performed. For those with PU on Arginaid Water supplementation, plasma arginine concentration and PU status were monitored every month. Patients with PU showed significantly lower plasma arginine concentration compared to those without PU (control vs. PU; 80.2±21.3 vs 62.8±14.7 nmol/ml, p<0.01). After the addition of Arginaid Water, plasma arginine concentration increased (before vs 3 months later; 57.9±1.8 vs 83.1±8.5, p<0.01), and PU area, perimeter, DESIGN-R and PUSH scores significantly improved. Plasma arginine was lower in PEG patients with PU. The healing rate of PU is improved with Arginaid Water supplementation. The findings from this study support the use of arginine supplementation in PEG patients with PU.


ChemInform Abstract: Synthesis of Fluorescent Substrates for Protein Tyrosine Phosphatase Assays

October 2010

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6 Reads

ChemInform

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.


ChemInform Abstract: Total Synthesis of (.+-.)-Aglaiastatin, a Novel Bioactive Alkaloid.

September 2010

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10 Reads

ChemInform

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.





Intraocular soluble IL-2 receptor alpha in a patient with adult T cell leukaemia with intraocular invasion

October 2006

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21 Reads

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8 Citations

The British journal of ophthalmology

It has been reported that human T cell lymphotropic virus type I (HTLV‐I) infection is related to a wide range of ocular disorders, such as intraocular lymphoma,1,2 uveitis,3 and cytomegalovirus (CNV) retinitis.4 The diagnosis of adult T cell leukaemia (ATL) cell infiltration in the eye is often difficult, even when characteristic ocular findings are present and cytological examinations of intraocular fluids are performed. It is well known that determination of patient serum interleukin 2 receptor alpha (sIL‐2Rα) levels is critical in the evaluation of the clinical status of the disease.5 We report here a patient with systemic ATL who developed vitreous opacities and subretinal lesions and in whom vitreous measurement of the soluble form of sIL‐2Rα provided information that could be used in making a diagnosis and in treating associated ocular disorders.


DHMEQ, a new NF-B inhibitor, induces apoptosis and enhances fludarabine effects on chronic lymphocytic leukemia cells

June 2006

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62 Reads

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47 Citations

Leukemia

Chronic lymphocytic leukemia (CLL) is a low-grade lymphoid malignancy incurable with conventional modalities of chemotherapy. Strong and constitutive nuclear factor kappa B (NF-kappaB) activation is a characteristic of CLL cells. We examined the effects of a new NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), on CLL cells. Dehydroxymethylepoxyquinomicin completely abrogated constitutive NF-kappaB activity and induced apoptosis of CLL cells. Apoptosis induced by DHMEQ was accompanied by downregulation of NF-kappaB-dependent antiapoptotic genes: c-IAP, Bfl-1, Bcl-X(L) and c-FLIP. Dehydroxymethylepoxyquinomicin also inhibited NF-kappaB induced by CD40 and enhanced fludarabine-mediated apoptosis of CLL cells. Results of this study suggest that inhibition of constitutive and inducible NF-kappaB by DHMEQ in combination with fludarabine is a promising strategy for the treatment of CLL.


Citations (53)


... The research on TiO 2 photocatalysts is steadily increasing since the discovery of UVlight assisted electrochemical water splitting [1]. The extensive research has shed light on the relevant mechanisms and reaction pathways [2][3][4]. As a result, more than four million tons of TiO 2 per year are nowadays produced to satisfy the growing research and industrial demand in environmental and energy-related fields [5,6]. ...

Reference:

Mixed Metal Oxide W-TiO2 Nanopowder for Environmental Process: Synergy of Adsorption and Photocatalysis
TiO2 photocatalysis: Fundamentals and applications
  • Citing Article
  • January 1999

Russian Journal of Electrochemistry

... Technologies that sustainably treat oxoanions directly to innocuous byproducts are ideal. Catalytic technologies (i.e., heterogeneous, photo-, electro-) have received attention for their ability to efficiently treat oxoanions to innocuous and stable byproducts (Mori et al., 1999Mori et al., , 2000 Kominami et al., 2005a; Zhang et al., 2007; Lozovskii et al., 2009; Li et al., 2010; Mishra et al., 2011; Hirayama et al., 2014; Pan et al., 2012; Gekko et al., 2012; Cappelletti et al., 2008; Liu et al., 2012; Tanaka et al., 2013; Gherbi et al., 2011; Qu et al., 2013; Noguchi et al., 2002; Zhao et al., 2011; Ye et al., 2013). Photocatalysis in particular is appealing because it could be operated using solar light. ...

Removal of bromate ion from water using TiO(2) and alumina-loaded TiO(2) photocatalysts
  • Citing Conference Paper
  • January 2002

Water Science & Technology

... Recent studies have demonstrated that MBD1 participated in the transcriptional silencing of MGMT, MLH1 and p53BP2 and so on (Yu et al. 2004, Danam et al. 2005, Lyst et al. 2006). In addition, previous study has suggested that MBD1 might also be involved in DNA repair through its interaction with methylpurine DNA glycosylase, which removes the damaged purines produced by methylating or oxidative agents (Shoda et al. 2003). Mutation analyses also revealed that a number of mutations in the MBD1 gene exist in colon and lung cancer cell lines (Bader et al. 2003). ...

Microsatellite instability analysis of ATL cells.
  • Citing Conference Paper
  • January 2003

AIDS Research and Human Retroviruses

... Eight switch LSIs and MCM-interface LSIs are mounted on the MCM substrate. The switch LSIs are fabricated by 0.25-m CMOS/separation by implanted oxygen (SIMOX) devices [11]. The switch LSI provides 4 2 switching, handling input and output line speeds of 10 Gb/s. ...

A 40-Gb/s 8X8 ATM switch lsi using 0.25-μm CMOS/SIMOX
  • Citing Article
  • May 1998

IEICE Transactions on Electronics

... The second property of the self-cleaning process is a photoinduced superhydrophilicity which enhances the wettability of the surface. The photocatalytic process is detailed in Linsebigler et al. (1995), Fujishima et al. (1998Fujishima et al. ( , 2000, Mills and Lee (2002) and more recently in Fujishima et al. (2008). ...

Titanium oxide-coated glass: Self-cleaning and anti-fogging properties and applications
  • Citing Article
  • January 1998

... As the number of cycles increases, the density of V O decreases, and the CA increases. This is attributed to the water molecules coordinating with the surface's oxygen vacancies, and dissociative adsorption occurs on the surface [64]. ...

Photoinduced surface wettability conversion of ZnO and TiO2 Thin Films
  • Citing Article
  • January 2001

The Journal of Physical Chemistry B

... Limited by the standard FPGA (Field Programmable Gate Array) devices used in this prototype system, it can handle a 10 Mb/s DTM signal. DTM may offer line speeds of more than 2.4 Gb/s line and throughputs of about 100 Gb/s, because the conventional highest time division switch module has Gb/s throughput [10] and considering the-state-of-the-art CMOS technology [11]. ...

A 40 Gb/s 8/spl times/8 ATM switch LSI using 0.25 /spl mu/m CMOS/SIMOX
  • Citing Conference Paper
  • January 1997

Digest of Technical Papers - IEEE International Solid-State Circuits Conference

... Prior to grow GaN, the Si substrate was cleaned in H 2 ambient at 1000 C, followed by the growth of about 200 nm-thick AlN buffer layer at 1060 C. A 1.2 lm-thick GaN layer was then grown on the AlN buffer layer at 1000 C. The GaN epitaxial layers grown on Si and an additional target n-Si(111) substrate used for the bonding were cleaned with acetone and ethanol in an ultrasonic bath for 300 s, dried under N 2 , and then loaded into the SAB chamber. After their surfaces were activated by fast Ar atom beam irradiation, 35,36 the GaN epitaxial layers were bonded to the target n-Si(111) substrates at room temperature under optimized bonding parameters of a vacuum pressure of 5 Â 10 À7 Pa and an external load of 1 GPa for 60 s, resulting in a Si/GaN/Si heterostructure. After bonding, the grown Si substrate was removed by mechanical polishing and chemical wet-etching. ...

Investigation of the bonding strength and interface current of pSi/n-GaAs wafers bonded by surface activated bonding at room temperature

Journal of Vacuum Science & Technology B Microelectronics and Nanometer Structures Processing Measurement and Phenomena

... Thus, E-selectin can also be used as a diagnostic and prognostic marker for HT. [12,13] Eikendal et al. conducted a study correlating the CAMs E-selectin, P-selectin, vascular CAM-1, intercellular CAM-1 and lipid profile parameters (total cholesterol, high-density lipoprotein [HDL]-cholesterol, triglycerides and glucose) with the thoracic aorta wall thickness and pulse wave velocity (PWV) as demonstrated by cardiovascular magnetic resonance imaging (CMR) performed on a 3.0 T multi-transmit clinical CMR system. Multivariate regression analysis (after adjusting for age, sex and smoking) revealed the following: • P-selectin correlated positively and significantly with aortic wall thickness (P = 0.01) • E-selectin correlated positively and significantly with PWV (P = 0.04) • vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 did not correlate with the aortic characteristics. ...

E-selectin level may be a useful clinical marker for endothelial damage in hypertension
  • Citing Article
  • June 2000

American Journal of Hypertension