T. Suemoto's scientific contributions

Citations

... The most famous derivative of PTZs is methylene blue (MB) (3,7-bis (dimethylamino) phenazathionium chloride), which is used as a drug with complex pharmacology and multiple clinical indications. Among PTZs derivatives are the Azure family, which contains Azure A, Azure B, and Azure C. Azure dyes have been used in diagnosis and treatment areas particularly in diagnosis of amyloid accumulation related diseases 6 , neurodegenerative diseases 7 , treatment of avian influenza virus 8 , oral cavity infection 9 , and protozoan infections 10 , in addition to the important role in pathological tau-tau association in Alzheimer disease [11][12][13] . Azure A (N 0 ,N 0 -dimethylphenothiazin-5-ium-3,7-diamine chloride) ( Figure 1) which is one of the tricyclic phenothiazine synthetic derivative dyes has been shown to prevent Tau aggregation in vitro 14,15 . ...