T S Nikitina's research while affiliated with Central Research Institute of Epidemiology and other places

Publications (8)

Article
Anti-HVA IgM, HBsAg, anti-HBc IgM, anti-HVC were determined in the blood sera and saliva specimens obtained from patients with acute hepatitis A, B, C (HA, HB, HC) and from healthy persons of the control group. 37 HA patients, 27 HB patients and 24 HC patients, observed in the dynamics of the disease (for a period of 1 month and longer from the app...
Article
To determine the present-day specific clinical features of viral hepatitis A (HA) in children, observation on 447 children aged 1 year and 10 months to 14 years with verified HA monoinfection was carried out. At the season of 1993 essential differences were observed in the clinical picture of HA: the disease took a more severe course with the preva...
Article
The authors describe the results of the first experience gained with the use of recombinant alpha 2-interferon in children with acute viral hepatitis B. The drug was administered rectally in combination with antioxidants (tocopherol). The study was carried out by the double blind method with randomization and two control groups (given tocopherol al...
Article
A total of 102 children aged 5 to 14 years with virus hepatitis B were examined for the status of the mononuclear phagocytic system in accordance with the absolute monocyte count in the circulating blood, esterase and acid phosphatase activity in the monocytes, for function of organ macrophages of the liver and spleen using dynamic scintigraphy wit...
Article
To form a judgement about function of liver and spleen macrophages (MP) in vivo, use was made of dynamic scintigraphy with Tc-colloid. Sixty-seven children aged 5 to 14 years were examined. Of these, 45 children were afflicted with virus hepatitis B (VHB), 16 with virus hepatitis A (VHA), and 6 children had VHA associated with asymptomatic HBsAg ca...

Citations

... Two different studies reported that vitamin E plasma levels were signifi cantly lower in children with CHB; therefore, combined therapy of interferon-␣ and vitamin E should be used as therapy. 21,22 Another study suggested that an antiviral and immunomodulator preparation named Viferon, produced as rectal suppositories containing recombinant ␣ -2b-interferon and anti-oxidants, should be used in complex therapy of viral chronic hepatitis B and C in children. In this case, it was claimed that higher complete response ratios were achieved. ...
... One Russian government respondent noted: "seroprevalence data for some regions show high antibodies; however, we do not have exact data for most regions in different age groups." Overall, the published epidemiological data in Russia were quite variable, suggesting variations in measurement, reporting, or interpretation [27][28][29]. In Russia, the literature reported several outbreaks in cities [30] and following natural disasters [31][32][33], some of which were mentioned by respondents. ...
... Some studies evaluated the detection of HBsAg in saliva and found that saliva could be used as an alternative sample for serum to identify HBV carriers [7,8,18,[55][56][57][58][59][60]. The oldest reports employed RIA as methodology assay for detecting HBV markers in saliva demonstrating sensitivity varying from 75% to 100% [54][55][56][57]. ...