T. Neogi's research while affiliated with Boston University and other places
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Publications (80)
Objective
To investigate the risks and trajectories of hospital admission for ambulatory care sensitive conditions (HACSCs) in gout.
Methods
Among individuals aged 35-85 years residing in Skåne, Sweden, in 2005, those with no doctor-diagnosed gout during 1998–2005 (n=576,700) were followed from January 1st 2006 until an HACSC, death, relocation ou...
Objective
The study objective was to determine the relationship of magnetic resonance imaging (MRI)-detected features of patellofemoral joint osteoarthritis to pain and functional outcomes.
Methods
We sampled 1,099 participants from the 60-month visit of the Multicenter Osteoarthritis Study (mean ± SD age: 66.8 ± 7.5 years; body mass index: 29.6 ±...
Objective
Knee osteoarthritis (OA) is predominantly characterized by pain with weight-bearing activities. Pain at rest also occurs but the mechanisms for this are not clear. We evaluated the relations of nociceptive signal alterations to weight-bearing and non-weight-bearing pain in knee OA.
Design
We used data from a NIH–funded longitudinal cohor...
Mindfulness-based stress reduction (MBSR) is an evidence-based non-pharmacological approach for chronic low back pain (cLBP), yet it is not readily available or reimbursable within primary care clinics. Primary care providers (PCPs) who wish to avoid prescribing opioids and other medications typically have few options for their cLBP patients. We pr...
Background
Pain is a hallmark symptom of hand osteoarthritis (OA). A subset of people with hand OA display centrally driven pain characteristics. Pain is driven by person-related factors, but how comorbidities are related to the hand OA pain experience is undetermined. Changes in pain pathophysiology and pain levels by for instants low-grade inflam...
Background
Classification criteria for calcium pyrophosphate deposition disease (CPPD) will facilitate clinical research on this common crystalline arthritis. ACR/EULAR are jointly sponsoring development of CPPD classification criteria using a multi-phase process.
Objectives
To report preliminary results from the first two phases of a four-phase p...
Background
There are known and established risk factors for gout flares; however, no study has examined the factors specifically associated with a polyarticular gout flare.
Objectives
Evaluate risk factors of a polyarticular gout flare in a longitudinal study of individuals with gout.
Methods
We used data from the Boston Online Gout Study, a long...
Objective:
Disagreement exists between rheumatology and primary care societies regarding gout management. This paper describes a formal process for gathering input from stakeholders in the planning of a trial to compare gout management strategies.
Methods:
We recruited patients, nurses, physician assistants, primary care clinicians, and rheumato...
Objective
Establish the impact of pain severity on the cost-effectiveness of generic duloxetine for knee osteoarthritis (OA) in the United States.
Design
We used a validated computer simulation of knee OA to compare usual care (UC) - intra-articular injections, opioids, and total knee replacement (TKR) - to UC preceded by duloxetine in those no lo...
Objective
There is an interest in identifying a metabolic OA phenotype. We therefore assessed the relation of diabetes and cardiovascular disease to prevalent and incident radiographic (ROA) and symptomatic knee osteoarthritis (SxOA).
Design
In two large cohort studies of individuals with or at risk for knee OA, the Multicenter Osteoarthritis Stud...
Gout is the most common inflammatory arthritis affecting nearly 4% of adults (9.2 millions) in the U.S. Initiation of urate‐lowering therapy (ULT) is strongly recommended for all patients with tophaceous gout, radiographic damage, or frequent gout flares. While allopurinol is the first‐line ULT, some patients do not tolerate or adequately respond t...
Objective
Bone marrow lesions (BMLs) contribute to pain and progression of knee OA. Bisphosphonates may be a potential disease-modifier through amelioration of BMLs. We sought to determine the effect of oral bisphosphonates on BML volume over 12 months.
Design
Women in the Osteoarthritis Initiative who newly initiated an oral bisphosphonate were p...
Current management of osteoarthritis (OA) is primarily focused on symptom control. Intra-articular corticosteroid (IACS) injections are often used for pain management of hip and knee OA in patients who have not responded to oral or topical analgesics. Recent case series suggested that negative structural outcomes including accelerated OA progressio...
Objective
To determine the association between dysregulated central pain processing and treatment response in rheumatoid arthritis (RA).
Methods
One‐hundred and eighty‐two participants with active RA were followed for 12 weeks after initiating a disease‐modifying anti‐rheumatic drug (DMARD). To assess central pain processing, participants underwen...
Background
Pressure pain threshold (PPT) is a measure of pain sensitization; altered pain mechanisms in the peripheral and/or central nervous system causing increased pain sensitivity. PPT testing may be a useful tool to classify pain phenotypes but requires special equipment not available in the clinic. The Doyle index (DI) is a clinical measure o...
Background
Overweight and obesity are well-known risk factors for osteoarthritis (OA) in weight-bearing joints. However, the role of increased body mass index (BMI) and waist circumference in OA of the non-weight-bearing joints is more controversial. Few hand OA studies have explored the associations between increased BMI/waist circumference and pa...
Background
Imaging plays an important role in determining structural disease severity and potential suitability of patients recruited to disease-modifying osteoarthritis drug (DMOAD) trials. It has been suggested that there may be three main structural phenotypes in OA, i.e., inflammation, meniscus/cartilage and subchondral bone. These may progress...
Importance
Prior studies have identified an association between obesity and prescription opioid use in the US. However, the pain conditions that are factors in this association remain unestablished.
Objective
To investigate the association between obesity and pain diagnoses recorded by primary care clinicians as reasons for prescription of opioids...
Importance:
Monitoring trends in prescription analgesic use among adults with musculoskeletal conditions provides insight into how changing prescribing practices, guidelines, and policy measures may affect those who need pain management.
Objective:
To evaluate trends in prescription opioid use and nonopioid analgesic use among adults with functi...
Résumé
L’hyperuricémie est une maladie courante qui, chez un certain nombre de patients, peut se compliquer de goutte. L’arthrose est la plus fréquente des arthropathies et coexiste fréquemment avec la goutte chez un même patient. La relation entre ces deux entités doit cependant être clarifiée, en particulier l’impact de l’arthrose sur le développ...
Objective:
Thiazide diuretic use is associated with higher bone mineral density (BMD) and possibly lower serum magnesium levels than loop diuretic use, and both high BMD and low serum magnesium have been linked to high prevalent knee osteoarthritis. This study aimed to compare the risk of a clinically relevant endpoint, knee replacement (KR) surge...
Objective
Pain is a significant burden for rheumatoid arthritis (RA) patients despite advancements in treatment. We examined the independent contribution of pain centralization to the pain experience of patients with active RA.
Methods
Two hundred and sixty‐three RA patients with active disease underwent quantitative sensory testing (QST) includin...
The prevalence of obesity has grown rapidly over the past several decades and has been accompanied by an increase in the prevalence of chronic pain and prescription opioid use. Obesity, through its association with pain, may represent an important contributor to the opioid epidemic. This cross-sectional study investigated the relationship between o...
Objective
To update the 1997 OMERACT-OARSI (Outcome Measures in Rheumatology-Osteoarthritis Research Society International) core domain set for clinical trials in hip and/or knee osteoarthritis (OA).
Methods
An initial review of the COMET database of core outcome sets (COS) was undertaken to identify all domains reported in previous COS including...
Objective
To assess the uptake of the OMERACT-OARSI (Outcome Measures in Rheumatology- Osteoarthritis Research Society International) core outcome set (COS) domains in hip and/or knee osteoarthritis (OA) trials.
Methods
There were 382 trials of hip and/or knee OA identified from the ClinicalTrial.gov registry from 1997 to 2017. Frequency of COS ad...
In 1992, the Food and Drug Administration (FDA) instituted the accelerated approval regulations that allow drugs or biologics for serious conditions that fill an unmet medical need to be approved on the basis of a surrogate endpoint or an intermediate clinical endpoint. The current definition of a serious condition includes chronic disabling condit...
Hyperuricemia is a common condition, and in a subset of patients leads to gout, the most common inflammatory arthritis. Osteoarthritis is the most common form of arthritis overall, and gout and osteoarthritis frequently coexist in the same patient. However, the relationship between the two remains poorly defined. More particularly, the impact of os...
Background
-Hyperuricemia and gout are associated with increased risk of cardiovascular disease (CVD). Xanthine oxidase inhibitors (XOI), allopurinol and febuxostat, are the mainstay of urate lowering treatment for gout and may have different effects on cardiovascular risk in patients with gout.
Methods
-Using U.S. Medicare claims data (2008-2013)...
Objective
The Patient Reported Outcomes Measurement Information System (PROMIS) is a calibrated item bank used to assess patient reported outcomes across multiple domains. The purpose of this study was to describe the performance of selected PROMIS measures in rheumatoid arthritis (RA) patients with active disease, initiating a disease‐modifying an...
Background:
The aims of this study were to define changes in catastrophizing that occur with initiation of a new disease-modifying antirheumatic drug (DMARD) and to examine the relationship between changes in Clinical Disease Activity Index (CDAI) and changes in catastrophizing.
Methods:
Participants in an ongoing multisite, prospective observat...
Calcium pyrophosphate (CPP) crystal deposition (CPPD) is prevalent, and can be associated with synovitis and joint damage. The older‐aged population predominantly affected by CPPD is growing rapidly. Since shortfalls exist in many aspects of CPPD, we conducted an anonymous survey of CPPD unmet needs, prioritized by experts from the Gout, Hyperurice...
At a time when advancing understanding of osteoarthritis (OA) has created opportunities for new treatments, development of treatments has remained considerably behind advances in other rheumatic diseases. We suggest elements of trial design and measurements that have inhibited success and offer suggestions that may help break the logjam. Among the...
Background:
Patients with gout are at an increased risk of cardiovascular (CV) disease including myocardial infarction (MI), stroke, and heart failure (HF).
Objectives:
The authors conducted a cohort study to examine comparative CV safety of the 2 gout treatments-probenecid and allopurinol-in patients with gout.
Methods:
Among gout patients ≥6...
Background:
Gout patients do not routinely achieve optimal outcomes related in part to suboptimal administration of urate lowering therapy (ULT) including first-line xanthine oxidase inhibitors allopurinol or febuxostat. Studies leading to the approval of febuxostat compared this agent to allopurinol in inappropriately low, fixed doses. We will co...
Objective:
To examine whether giant cell arteritis (GCA) is associated with increased all-cause mortality and whether mortality differs according to age, sex, and calendar year of cohort entry.
Methods:
Using the UK-based Clinical Practice Research Datalink we identified 9778 newly diagnosed GCA patients from 1990-2014, and up to 10 non-vasculit...
Objectives:
To evaluate the associations between granulomatosis with polyangiitis (GPA) and a wide range of comorbidities in patients with GPA compared with population-based non-vasculitis patients.
Methods:
Using the UK-based Clinical Practice Research Datalink we identified 570 incident patients with GPA in 1990-2014, and for each case, we sel...
Osteoarthritis (OA) is the most common form of arthritis, with knee OA itself being among the most common conditions and a leading cause of disability among older adults worldwide. Pain is a key symptom in the decision to seek medical attention, yet available therapies for managing OA are limited with only minimal or moderate efficacy. Current appr...
Objective:
Pain sensitization may contribute to pain severity in rheumatoid arthritis (RA), impacting assessment of disease activity. We examined whether pain processing mechanisms were associated with disease activity among RA patients with active disease.
Methods:
This study includes 139 subjects enrolled in the Central Pain in Rheumatoid Arth...
Objective:
To evaluate the associations between GCA and vascular diseases and other comorbidities in patients with GCA compared with non-vasculitis patients.
Methods:
Using the UK-based Clinical Practice Research Datalink we identified 9778 newly diagnosed GCA patients in 1990-2014, and up to 10 non-vasculitis patients randomly matched to each c...
Testing a reading exercise for identification of several typical crystal such as the negatively birefringent needle-shaped crystals that are under polarized light microscopy is the gold standard for diagnosing gout. The objective of this study was to assess current performance of crystal identification by professionals involved in examining synovia...
Objective:
Electronic clinical quality measures (eCQMs) rely on computer algorithms to extract data from electronic health records (EHRs). On behalf of the American College of Rheumatology (ACR), we sought to develop and test eCQMs for rheumatoid arthritis (RA).
Methods:
Drawing from published ACR guidelines, a working group developed candidate...
Background
Gout is a quite prevalent disorder in affluent countries, with the prevalence in males being 3–4 times higher than in females [1]. In practice, gout may be perceived as a “males” disorder and it has been suggested that the phenotype of gout differs between males and females, due to selection bias or by nature of the disease.
Objectives...
Objective: To determine the acceptable level of positive predictive value (PPV) and negative predictive value (NPV) for classification criteria for gout, given the type of study. Methods: We conducted an international web-based survey with 91 general practitioners and rheumatologists experienced in gout. Conjoint analysis was used as the framework...
Background:
Certain immunosuppressant drugs are known to increase the risk of myeloid neoplasms although it is unclear if underlying autoimmune disorder itself increases the risk of myeloid neoplasms.
Methods:
Using a nested case-control study in the General Practice Research Database (GPRD), we estimated the relative risk of myeloid neoplasms,...
Citations
... Studies have shown that it starts from the degenerative changes of knee articular cartilage, gradually affects the subchondral plate and joint capsule, and finally leads to the progressive destruction of articular cartilage and synovial inflammation [12]. Patients with KOA always have clinical symptoms such as joint pain, swelling, and mobility impairment [13][14][15]. KOA is classified as joint pain in traditional Chinese medicine. The Yellow Emperor's Internal Canon of Medicine believes that the combination of wind, cold, and dampness can lead to bone diseases. ...
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... Not all out-patient physical therapists performed telehealth during the shutdowns in the United States (15). It appears that some form of telehealth will continue in most areas of the world long after the pandemic has stabilized (28)(29)(30)(31)(32)(33)(34). ...
... It is expected that by 2030, 20% of adults will have developed OA in Western Europe and North America [3], which imposes the morbidity and economic burdens on patients, their families and the society [4]. Notably, recent studies have also showed robust evidence that OA is a significant risk factor for cardiovascular diseases (CVD) and suggested that patients with OA are twice as likely to develop ischemic heart disease and heart failure which increase mortality [5,6]. ...
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... Characteristics of the included studies are reported in Table 2 [36,38,39,[63][64][65][66][67][68][69][70][71][72][73][74][75][76]. The studies were conducted in Europe (n = 15), North America (n = 19) [36, 37, 39, 42, 45, 46, 48, 51, 54-56, 59, 60, 67-72, 75], South America (n = 1) [65], and Asia (n = 7) [35,44,62,66,73,74,76], and there was also a multi-continental study (n = 1) [34]. ...