Swati U. Kolhe’s research while affiliated with AISSMS College of Pharmacy and other places

Introduction: A significant risk factor for cardiovascular illnesses is hyperlipidemia, which is characterized by high blood lipid levels. Innovative pharmaceuticals made from organic materials like plants are desperately needed to treat hyperlipidemia. Compared to synthetic medications, these possible plant-based remedies might provide a therapeutic option that is both economical and free of adverse effects. We performed an experiment utilizing an acute hyperlipidemia model to assess the hypolipidemic efficacy of an aqueous flower extract (FE). Methods: We used 30 female Wistar rats for the experiment, which were split into five groups (n = 6 each) for each model. The standard employed was fenofibrate (250 mg/kg p.o.), and Triton X-100 was used to generate hyperlipidemic activity in the rats. Our study evaluated the effectiveness of an aqueous flower extract over a 15-day period at dosages of 250 and 500 mg/kg (p.o.). Several parameters were used to evaluate the hypolipidemic activity. Results: In the study, the flower extract treatment demonstrated significant positive effects. It notably reduced cholesterol, triglycerides, and LDL levels induced by Triton X-100, indicating its potential in lowering elevated lipid levels. Furthermore, the extract substantially increased HDL levels. However, it did not have a significant impact on VLDL levels. Conclusion: Our study suggests that the flower extract (FE) has the potential to act as a hypolipidemic agent, possibly attributed to its capability to inhibit cholesterol synthesis and intestinal lipid absorption. The FE is abundant in phytochemicals such as flavonoids and phenols, which could be contributing factors to its hypolipidemic effect.

Cinnamomum is a genus belonging to the Lauraceae family and has been traditionally used for medicinal and culinary purposes. Southern India and Sri Lanka are the native habitats of the Cinnamomum genus. The two most significant types of cinnamon are Ceylon and cassia, this can be bought on marketplaces in both Europe and the US. Cinnamon is rich in phytochemicals such asPhyto alkaloids, Bioflavonoids, proteins, glycosides, phenols, terpenoids, tannins, and carbohydrates. The most significant components of cinnamon are cinnamaldehyde, cinnamate and cinnamic acid which are found in the essential oil and contribute to the aroma and numerous biological properties associated with cinnamon. Cinnamon is used in a variety of goods, including traditional spices, incense, fragrances, and food. It is also used in Ayurvedic medicine to regulate the Vata and Pitta elements in the body. It's been discovered that cinnamon possesses anti-diabetic, antibacterial, antioxidant, anti-inflammatory, anticancer, anti-HIV activity, wound healing, and anti-anxiety and depression properties. This review article offers comprehensive insights into theplant morphology, ancestral uses, chemical constituents with their pharmacological actions of various species of cinnamon as medicine.

Introduction: Colocasia esculenta Linn (family: Araceae; synonym: Arum esculentum Linn; Taro) is one of the most important tubers crops worldwide and has been employed for medicinal applications for a significant period. Traditionally, in Indian and Chinese medicine, taro is utilized for many years for medicinal applications such as hypoglycaemic, antifungal, antimicrobial, hepatoprotective, and nervine tonic Taking into consideration the traditional claims, C. esculenta has the potential to be a useful for antioxidant activity. With this perspective in mind, the current research aimed to investigate the antioxidant potential of C. esculenta corms. Method: In vitro antioxidant activity aqueous extract of C. esculenta corms was studied by DPPH method. Ascorbic acid was used as a reference standard. The absorbance of various concentrations of corm extract and ascorbic acid were measured by using UV–Visible Spectrophotometer and the percent radical scavenging activity (% RSA) of the DPPH free radical was measured. Results: The Radical scavenging activity of corm extract of C. esculenta at 400μg/mL was found to be 80.33% at absorbance 0.142. The IC50 value of C. esculenta was found to be 120.16μg/mL which was calculated by using y = 0.0952x+38.56 equation. The Radical scavenging activity of Ascorbic acid at 400μg/ml was found to be 87.67% at absorbance 0.089. The IC50 value of Ascorbic acidwas found to be 28.05μg/mL which was calculated by using y = 0.091x+47.43 equation. Conclusion: Our study indicates that the corm extract has the potential as an antioxidant agent, possibly inhibiting DPPH, when compared with standard ascorbic acid. However, the chemical constituents present in the extract such as saponins, steroids, carbohydrates, glycosides, tannins, flavonoids and proteins may be responsible for such activity.

This review highlights the significance of licorice (Glycyrrhiza glabra) as a traditional medicinal plant with diverse therapeutic benefits. In India, where traditional remedies are widely preferred over allopathic medicines, thanks to its natural nature and fewer side effects, licorice has a notable position. Being one of the four "Medhya Rasayana" in Ayurveda, G. glabra has been used for memory enhancement, cognition, and nerve function improvements for over 4,000 years. Liquorice cultivation is widespread in several countries, and its chemical constituents include flavonoids, glycosides, triterpenoid aglycone, glycyrrhizin, and Glabridin. The plant has demonstrated multiple pharmacological activities such as, anti-inflammatory, antioxidant, memory enhancement, antistress, hepatoprotective, immunomodulation, antihyperglycemic, and anticancer effects. moreover, licorice shows antimicrobial, antinociceptive, dermatological, and neuroprotective properties. These diverse therapeutic effects have led to its potential use in various health-related concerns. To completely comprehend its modes of action, additional research is needed, define optimal dosages, and ensure long-term safety and efficacy. In conclusion, licorice stands as a significant herbal medicine with a rich history of use and remarkable potential for enhancing human health. Its multiple biological activities make it a valuable candidate for complementary and alternative medicine. Standardization of licorice extracts and rigorous quality control are essential for consistent therapeutic applications. As scientific research expands, licorice-based products are anticipated to play an increasingly vital role in holistic healthcare.

Adenocalymma alliaceum, commonly known as Garlic Vine or Lahsun bel, is an herbal shrub belonging to the family Bignoniaceae. It is native to northern Brazil and the Amazon rainforest, and certain species can also be found in the Chhattisgarh, Kerala states of India. This evergreen plant is highly valued for its ornamental qualities, with bright green leaves and tri-colored blooms that emit a distinct garlic-like fragrance. It grows up to 6-8 feet in height and is popular for landscaping purposes. The plant has various pharmacological activities that have been studied particularly in the management of diabetes mellitus. The bark, leaves, stems, and roots of Adenocalymma alliaceum contain a range of bioactive compounds that have been used to treat different diseases and disorders. Phytoconstituents such as diallyl disulfide and diallyl trisulfide are major chemical constituents of the plant, exhibiting antimicrobial, antihyperlipidemic, antifungal, and antimycotic activities. These properties make Adenocalymma alliaceum a promising source for the development of allopathic drugs. While the plant has traditional and cultural significance, it has also gained attention for its potential therapeutic properties. However, it is important to note that although it is used as a folk medicine in local communities, it is not extensively mentioned in published books or literature. In summary, Adenocalymma alliaceum is an intriguing natural resource with a rich cultural heritage and significant pharmacological potential. Further research and exploration of this plant may uncover additional therapeutic benefits and contribute to the development of novel drugs and treatments.

Since the beginning of time people have used plants as a solution for different infections and/or diseases. With the approach of current synthetic medicines, plant medication has frequently been subjected to the edge of therapeutic modalities. However, it is progressively being recognized that the synthetic therapeutic agents have a few limitations particularly in ongoing chronic illnesses like hyperlipidaemia. Hyperlipidaemia is an ailment characterised by an expansion in at least one of the plasma lipids, including cholesterol, triglycerides, plasma lipoproteins such as low density lipoprotein (LDL) and very low density lipoprotein (VLDL) alongside diminished high-density lipoprotein (HDL) levels. Research is continuous to find more current medications and a few novel helpful targets are being investigated for hyperlipidaemia. In the current review, the types of hyperlipidaemias, lipid metabolism, causes and risk factors of hyperlipidaemia has been explained along side the plant derived bioactiveand extracts that have been demonstrated in the past 15 years to have a potential in treatment of hyperlipidaemia has been discussed.

Since the beginning of time people have used plants as a solution for different infections and/or diseases. With the approach of current synthetic medicines, plant medication has frequently been subjected to the edge of therapeutic modalities. However, it is progressively being recognized that the synthetic therapeutic agents have a few limitations particularly in ongoing chronic illnesses like hyperlipidaemia. Hyperlipidaemia is an ailment characterised by an expansion in at least one of the plasma lipids, including cholesterol, triglycerides, plasma lipoproteins such as low density lipoprotein (LDL) and very low density lipoprotein (VLDL) alongside diminished high-density lipoprotein (HDL) levels. Research is continuous to find more current medications and a few novel helpful targets are being investigated for hyperlipidaemia. In the current review, the types of hyperlipidaemia, lipid metabolism, causes and risk factors of hyperlipidaemia has been explained alongsidethe plant derived bioactiveand extracts that have been demonstrated in the past 15 years to have a potential in treatment of hyperlipidaemia has been discussed.