Sushma Ashwin's research while affiliated with Victoria University Melbourne and other places

Publications (4)

Article
Full-text available
Background: Observational data during the pandemic have demonstrated mixed associations between frailty and mortality. Aim: To examine associations between frailty and short-term mortality in patients hospitalised with coronavirus disease 2019 (COVID-19). Methods: In this systematic review and meta-analysis, we searched PubMed, Embase and the...
Article
Full-text available
Frailty is often used in clinical decision-making for patients with coronavirus disease 2019, yet studies have found a variable influence of frailty on outcomes in those admitted to the ICU. In this individual patient data meta-analysis, we evaluated the characteristics and outcomes across the range of frailty in patients admitted to ICU with coron...
Preprint
Full-text available
Purpose: Frailty is often used in clinical decision-making for patients with COVID-19, yet studies have found variable influence of frailty on outcomes in those admitted to the intensive care unit (ICU). In this individual patient data meta-analysis, we evaluated the characteristics, and outcomes of frail patients admitted to ICU with COVID-19. Met...
Article
Full-text available
Rationale: Initial reports of case fatality rates (CFR) among adults with coronavirus diease-19 (COVID-19) receiving invasive medical ventilation (IMV) are highly variable. Objective: To examine the CFR of patients with COVID-19 receiving IMV. Methods: Two authors independently searched PubMed, Embase, medRxiv, bioRxiv, the COVID-19 living syst...

Citations

... To date, seven studies have performed metaanalyses to assess the impact of frailty on short-term mortality risk from COVID-19 (15, 16, 24, 51- analysis in this population. The primary outcome of all studies was short-term mortality, defined as in-hospital death or within 30 days, although three of them (24,51,52) also reported additional outcomes such as delirium, risk of COVID-19 severity, admission to intensive care unit, application of invasive mechanical ventilation, and long hospital length of stay. For screening purposes for frailty in COVID-19 settings, CFS emerges as a feasible and practical tool to enable efficient workflow within hospitals, even when faced with limited human resources and increasing demand for medical services as in the pandemic era (17, 54, 55). ...
... [28,39] One IPD-MA had frailty as the exposure. [40] A. Shows overlap between the focus, included study designs, and type of IPD-MA for all the ongoing or completed IPD-MAs. B. Shows overlap between the included study population, interventions/exposures, and outcomes of all the ongoing or completed IPD-MAs. ...
... A high proportion of diseased patients require hospitalization, and a small subset with severe coronavirus disease 2019 (COVID-19) become critically ill and require invasive mechanical ventilation (IMV) for life-threatening respiratory failure [2][3][4][5]. High mortality has been reported in this subpopulation [4,[6][7][8][9], irrespective of survival benefits from established treatments, such as corticosteroids and IL-6 receptor antagonists [10,11]. ...