Surendra Kumar Shukla's research while affiliated with University of Oklahoma Health Sciences Center and other places
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Publications (5)
Therapeutic vaccines are a promising alternative for active immunotherapy for different types of cancers. Therapeutic cancer vaccines aim to prevent immune system responses that are not targeted at the tumors only, but also boost the anti-tumor immunity and promote regression or eradication of the malignancy without, or with minimal, adverse events...
Chemotherapy is a life-sustaining therapeutic option for cancer patients. Despite the advancement of several modern therapies, such as immunotherapy, gene therapy, etc., chemotherapy remains the first-line therapy for most cancer patients. Along with its anti-cancerous effect, chemotherapy exhibits several detrimental consequences that restrict its...
Purpose of Review
An imbalance in reactive oxygen species (ROS) homeostasis can wreak damage to metabolic and physiological processes which can eventually lead to an advancement in cardiovascular diseases (CVD). Mitochondrial dysfunction is considered as a key source of ROS. The purpose of the current review is to concisely discuss the role of bioa...
Interceding nutrients have been acquiring increased attention and prominence in the field of healing and deterrence of various disorders. In this light, the present article encompasses several facets of ketogenic diet as an immunomodulator with respect to its expansive clinical applications. Accordingly, several scientific records, models, and case...
Citations
... The immunosuppressive tumor microenvironment had a role in the cancer vaccines' inability to mediate sustained regression of tumors in several of the clinical investigations. According to preclinical and early clinical studies, monotherapy is less effective than combining chemotherapy or checkpoint blockade with therapeutic cancer vaccines [129][130][131]. Therapeutic cancer vaccines promote immune cells' infiltration into the tumor microenvironment (TME) and cytotoxic immune cell activation, whereas immune checkpoint inhibitors (ICIs) stop and/or reverse the immune cells' dysfunction [132]. ...
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... The poor immunogenicity of tumor antigens and tumor immune evasion mechanisms make the development of cancer vaccines challenging [140]. One of the major obstacles to the development of a successful cancer vaccine is the targeting of tumor antigens that may have low immunogenicity in the tumor environment or that could mutate to avoid the immune response [141]. ...
... The immunosuppressive tumor microenvironment had a role in the cancer vaccines' inability to mediate sustained regression of tumors in several of the clinical investigations. According to preclinical and early clinical studies, monotherapy is less effective than combining chemotherapy or checkpoint blockade with therapeutic cancer vaccines [129][130][131]. Therapeutic cancer vaccines promote immune cells' infiltration into the tumor microenvironment (TME) and cytotoxic immune cell activation, whereas immune checkpoint inhibitors (ICIs) stop and/or reverse the immune cells' dysfunction [132]. ...
