Sung Ku Ahn’s research while affiliated with Yonsei University Hospital and other places

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Publications (159)


Dr. Donald S. Mattson and His Service in Gangwon Province
  • Article
  • Full-text available

May 2023

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14 Reads

Yonsei Medical Journal

Sang-Hoon Lee

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Solam Lee

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Jong Won Yoon

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[...]

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Sung Ku Ahn
Download

Fig. 2. (A) Dr. Roth in surgery and (B) during outpatient treatment.
In Memory of Dr. Robert Frank Roth: Founder of Plastic Surgery in the Gangwon Province

April 2023

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9 Reads

Yonsei Medical Journal




Decrease of Ceramides with Long‐Chain Fatty Acids in Psoriasis: Possible Inhibitory Effect of Interferon Gamma on Chain Elongation

July 2021

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32 Reads

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26 Citations

Experimental Dermatology

Reportedly, decreases in fatty acid (FA) chain length of ceramide (CER) are associated with interferon‐γ (IFN‐γ), which shows increased expression in psoriasis. However, the underlying mechanism of this association remain unclear. Therefore, in this study, we aimed to clarify this association between FA chain length of CER , IFN‐γ, and the major transcriptional factors involving psoriasis. CER profiling according to FA chain length and class was performed in murine epidermis (n = 10 BALB/c mice topically treated with imiquimod (IMQ), n = 10 controls) and human stratum corneum (SC) (n = 12 psoriasis, n = 11 controls). The expression of lipid synthetic enzymes, including elongases (ELOVLs), in murine epidermis was also measured using RT‐PCR. Furthermore, the association of IFN‐γ with various enzymes and transcription factors involved in the generation of long‐chain CERs was also investigated using in vitro keratinocyte. A significant decrease in the percentage of long‐chain CERs was observed in psoriasis‐like murine epidermis and human psoriatic SC. Additionally, the expression levels of ELOVL1, ELOVL4, and ceramide synthase3 (CerS3) were significantly decreased in psoriasis‐like murine epidermis and IFN‐γ‐treated keratinocyte. There was also a significant decrease in the expression of transcriptional factors, including peroxisome proliferator‐activated receptor (PPAR), in IFN‐γ treated keratinocyte. Thus, it could be suggested that IFN‐γ may regulate ELOVL and CerS levels by down‐regulating the transcriptional factors. Additionally, given the possible involvement of PPARs or liver X receptor agonist in the CER elongation process, they may serve as potential therapeutic agents for lengthening the CER FAs in psoriasis.




Fig. 2. Distribution of the Baumann skin type by region. There was a difference in not only the order of Baumann skin types by region, but also the diversity of reported types in each region. (A) Seoul, (B) Gyeonggi-do/Incheon, (C) Chungcheong-do, (D) Gyeongsangbuk-do, (E) Gyeongsangnam-do, (F) Jeolla-do, (G) Gangwon-do, and (H) Jeju-do. O: oily, D: dry, S: sensitive, R: resistant, N: non-pigmented, P: pigmented, T: tight, W: wrinkled.
Fig. 3. Distribution of the Baumann skin type by age. There was no obvious regular pattern in the rankings of skin type for each age group. (A) Twenties, (B) thirties, (C) forties, and (D) fifties. O: oily, D: dry, S: sensitive, R: resistant, N: non-pigmented, P: pigmented, T: tight, W: wrinkled.
Demographic data of all respondents (n=1,000)
Comparison of the skin type characteristics between males noted in the present study and females described in the study by Ahn et al. 5
Baumann Skin Type in the Korean Male Population

December 2019

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783 Reads

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11 Citations

Annals of Dermatology

Background: Research into the Baumann skin type (BST) has recently expanded, with growing interest in the development of an efficient and effective skin type classification system for better understanding of this skin condition. Objective: We aimed to identify male-specific skin type characteristics with investigation into the distribution of BST by age and region in the Korean male population and to determine the intrinsic and extrinsic factors related to skin type. Methods: A questionnaire was administered to collect information about age, region, working behavior, drinking behavior, smoking behavior, usual habit of sun protection, medical history, and the BST which consisted of four parameters; oily (O) or dry (D), sensitive (S) or resistant (R), pigmented (P) or non-pigmented (N), and wrinkled (W) or tight (T). Results: We surveyed 1,000 Korean males aged between 20 and 60 years who were divided equally by age and region. Of the total respondents, OSNW type accounted for the largest percentage and ORPW type the lowest. In terms of Baumann parameters, O type was 53.5%, S type was 56.1%, N type was 84.4% and W type was 57.5%. Several behavioral factors were found to have various relationships with the skin type. Conclusion: The predominant skin type in the Korean male respondents was OSNW type, and the distribution of skin types with regards to age and region was reported to be distinct. Therefore, skin care should be customized based on detailed skin types considering the various environmental factors.




Citations (77)


... Psoriasis-associated altered circulating lipid levels 45 and abnormal lipid composition in plaque and nonlesional skin 3 have been linked with decreased fatty acid elongation and disruption of the skin barrier function. [46][47][48][49] For instance, ELOVL3, FADS1 and FADS2, which encode enzymes that participate in the elongation of long-chain fatty acids are downregulated in plaque and non-lesional skin compared to healthy skin. 34,[50][51][52][53][54] The upregulation of genes such as ELOVL3 and PECR in non-lesional skin and ELOVL3 and FADS2 in plaque skin may improve lipid barrier function, suggesting that bevacizumab could potentially alleviate epidermal barrier dysfunction and limit disease progression in psoriasis. ...

Reference:

Vascular Endothelial Growth Factor a Inhibition Remodels the Transcriptional Signature of Lipid Metabolism in Psoriasis Non-Lesional Skin in 12 H Ex Vivo Culture
Decrease of Ceramides with Long‐Chain Fatty Acids in Psoriasis: Possible Inhibitory Effect of Interferon Gamma on Chain Elongation
  • Citing Article
  • July 2021

Experimental Dermatology

... Ultimately, conclusions are derived from consumer self-reports gathered through a questionnaire. Comparison of data gathered in China, Korea, and the US indicate no significant difference in skin type prevalence between Asian and Caucasian populations [5], which supports the BSTI as a valuable and comprehensive tool for determining skin types [6][7][8]. ...

Baumann Skin Type in the Korean Male Population

Annals of Dermatology

... A patient waiting for treatment described their experience by saying, "We await the medical missionary workers like children waiting for their parents. " From 1925 to 1929, Sa Young Ahn 3 and Eun-gye Lee (two doctors trained in Severance Hos-pital) worked as doctors in the Swedish Methodist Hospital. In particular, Ahn served the community faithfully through many different roles, including medical service to teaching as well as missionary and administrative work (Singanhoe). ...

Dr. Sa Young Ahn (1890–1968), A Compassionate Devotion to Humanity

Yonsei Medical Journal

... The Swedish Methodist Hospital (Fig. 2) re-opened in February 1925, thanks to the proactive efforts of a medical missionary worker named Anderson. 2 The closure of the hospital turned out to be a blessing in disguise, as the people of the area began to appreciate the hospital more in its absence. For a short period after its re-opening, the hospital only offered out-patient treatments due to the time required to train assistants and nurses required to operate the hospital. ...

Albin Garfield Anderson (安道善, 1882–1971): A History of Medical Missionary Work

Yonsei Medical Journal

... Наиболее часто данные изменения определяются в более позднем возрасте у женщин. При этом внутриопухолевые жировые депозиты различаются по морфологии и размерам по сравнению с подкожной клетчаткой при световой микроскопии [20]. Различают также атипические нейрофибромы, состоящие из клеток с гиперхромными ядрами. ...

Liponeurofibroma: Clinicopathological features and histogenesis
  • Citing Article
  • January 2018

The Journal of Dermatology

... Ultimately, conclusions are derived from consumer self-reports gathered through a questionnaire. Comparison of data gathered in China, Korea, and the US indicate no significant difference in skin type prevalence between Asian and Caucasian populations [5], which supports the BSTI as a valuable and comprehensive tool for determining skin types [6][7][8]. ...

Baumann Skin Type in the Korean Female Population

Annals of Dermatology

... There are only three reports of porokeratosis ptychotropica in the Korean literature [11][12][13], and 45 cases have been reported in the dermatologic literature. Therefore, in this case report, we attempted to highlight the awareness of this condition and emphasize that clinicians should consider porokeratosis ptychotropica in their differential diagnosis when encountering pruritic eruptions in the gluteal regions. ...

Porokeratosis Ptychotropica Coexisting with Tinea Corporis

Annals of Dermatology

... These results tell us that the prevalence of psoriasis is low in sub-Saharan Africa and lower than that of Western countries. Indeed, in a systematic review, Parisi et al. demonstrated that psoriasis is unevenly distributed across geographic regions and is more common in high-income countries and regions with older populations [11]. The study population was dominated by men with a sex ratio of [14] in their study in Maghreb found a female predominance with a sex ratio of 0.6. ...

The Clinical Profile of Patients with Psoriasis in Korea: A Nationwide Cross-Sectional Study (EPI-PSODE)

Annals of Dermatology

... Other abnormalities can include horseshoe kidneys, hernias, hearing defects, intellectual disability and congenital heart disease [11,14]. From published research relating to FDH, there are only nine cases of unilateral/almost unilateral FDH, out of approximately 250 cases [15][16][17][18][19][20][21][22]. This report demonstrates a rare case of FDH presenting with unilateral symptoms and will subsequently only be the 10th unilateral FDH published in the literature and only the second male case. ...

Almost Unilateral Focal Dermal Hypoplasia

Annals of Dermatology

... Hypersensitivity reactions to injected agents, such as hyaluronan, can cause symptoms similar to those of septic arthritis, including joint pain and swelling [58]. Additionally, bone conditions like Gorham disease, SAPHO syndrome, chronic recurrent multifocal osteomyelitis, Paget disease, systemic mastocytosis, and synovial chondromatosis can present with atypical and challenging clinical manifestations [30]. ...

A Rare Cutaneous Adverse Reaction after Intra-Articular Injection of Hyaluronic Acid

Annals of Dermatology