Sundas Asghar’s scientific contributions

Cinnamon is a perennial plant deeply rooted in the world of ethnopharmacology. It is one of the most ubiquitous spices revered globally. Its historical use as a traditional phytomedicine spans several centuries. Cinnamon is a medicinal plant with different compounds in its bark, leaves, fruits, and roots, like cinnamaldehyde, cinnamate, and cinnamic acid. Research on animals, in-vivo and in-vitro, showed that cinnamon has many health benefits as per Ayurveda and medical. These benefits include its ability to fight against various bacteria and fungi, and even some viruses. Similarly, It helps to reduce swelling and also works as an antioxidant. Cinnamon shows promising results in managing conditions like diabetes and cardiovascular health, and it also has effects as an antidepressant and even the potential to inhibit cancer progression. Additionally, its perceived efficacy as an analgesic underscores its multifaceted role in promoting human health. While this review comprehensively illuminates the medicinal and Ayurvedic attributes of cinnamon in both preclinical and clinical studies, its widespread utilisation in everyday life underscores its cultural and practical significance. Nevertheless, given the complex nature of its effects, this review highlights the imperative need for further research to establish comprehensive and conclusive recommendations regarding its optimal usage and potential therapeutic benefits.

The complex landscape of mRNA vaccines is explored in this in-depth review, which focuses on the cutting edge of vaccine research against the deadly parasite Plasmodium falciparum. Parasite life cycle, significance, and host range are introduced, and then the importance of developing new vaccines is stressed. The report elucidates the context of vaccine development, exposing the merits of immunization and the difficulties faced by malaria vaccine efforts. Before diving into an in-depth investigation of new technologies, it is helpful to get a firm grounding in the history and current practices of vaccine development. In particular, the pros and cons of RNA vaccines for protecting against Plasmodium are discussed at length. This review concludes with an optimistic look into the future of mRNA vaccines, emphasizing their potential to treat not only malaria but also other infectious illnesses. The analysis highlights the speed and potential of mRNA vaccine development and tailored cancer vaccines at a time when global vaccination equality is of paramount importance. This voyage of evaluation spans the promise and limitations of mRNA vaccines, providing a complete picture of how they may or may not impact disease prevention and international health security.

Crimean-Congo One of the most significant vector-borne illnesses with the potential to spread to humans after a tick bite is hemorrhagic fever (CCHF). In the Middle East and Asia, the disease is very common. contaminated tick bites, manual tick removal, and contact with contaminated tissue, blood, patients, or cattle during the acute viremic phase are risk factors for this disease. Clinical signs of the illness include fever, muscle discomfort, and increasing hemorrhages. Increased levels of creatinine phosphokinase (CPK), alanine transaminase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) are detected by biochemical testing. Pro-thrombin tests result in longer clotting times, and pathogenesis is mostly associated with epithelial destruction during viral replication and secondary cytotoxic molecule secretion. Endothelial activation is brought on by these substances, which leads to function loss. Infusions of plasma or blood are used in supportive therapy to treat or manage patients. Based on the most recent research, ribavirin, an antiviral medication that effectively prevents the disease, can be used to treat community-onset heart failure. Workers in healthcare are more likely to have infections. A thorough review of the viral epidemiology, zoonotic viewpoints, and important risk factors for community-acquired pneumonia (CCHF) in several Middle Eastern and Asian nations is provided in this book chapter.

Crimean-Congo One of the most significant vector-borne illnesses with the potential to spread to humans after a tick bite is hemorrhagic fever (CCHF). In the Middle East and Asia, the disease is very common. Contaminated tick bites, manual tick removal, and contact with contaminated tissue, blood, patients, or cattle during the acute viremic phase are risk factors for this disease. Clinical signs of the illness include fever, muscle discomfort, and increasing hemorrhages. Increased levels of creatinine phosphokinase (CPK), alanine transaminase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) are detected by biochemical testing. Pro-thrombin tests result in longer clotting times, and pathogenesis is mostly associated with epithelial destruction during viral replication and secondary cytotoxic molecule secretion. Endothelial activation is brought on by these substances, which leads to function loss. Infusions of plasma or blood are used in supportive therapy to treat or manage patients. Based on the most recent research, ribavirin, an antiviral medication that effectively prevents the disease, can be used to treat community-onset heart failure. Workers in healthcare are more likely to have infections. A thorough review of the viral epidemiology, zoonotic viewpoints, and important risk factors for community-acquired pneumonia (CCHF) in several Middle Eastern and Asian nations is provided in this book chapter. The pathophysiology and preventative measures of CCHF have also been examined, along with laws and policies pertaining to public education campaigns, research, and development projects that aim to prevent and control infections and are necessary on a worldwide scale.