Sundaram Hariharan’s research while affiliated with University of Pittsburgh and other places

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Publications (1)


Figure 1: Testing for COVID-19 infection in ESRD patients on long-term hemodialysis treatment (n = 705) and hemodialysis staff (n = 103) at 9 hemodialysis centers. The number and percentage of COVID-19 positive patients and staff and their subsequent mortality
From Infection to Immunity - Impact of COVID-19 Across Nine Hemodialysis Centres in Mumbai
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November 2021

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1 Citation

Indian Journal of Nephrology

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Sundaram Hariharan

Introduction: There are several studies of symptomatic hemodialysis patients with proven COVID-19 infection. However, there is paucity of data on asymptomatic COVID-19 infection in the outpatient hemodialysis population. The true prevalence and transmission of this infection in hemodialysis centres is unknown. This study was conducted across hemodialysis centers by testing all patients and staff for COVID-19 PCR and later for IgG antibody, irrespective of their symptoms. Methods: All 705 hemodialysis patients and 103 dialysis staff across nine centres, were tested for COVID-19 over a period of 54 days of the pandemic, and for COVID IgG antibody of available enrolled staff and patients, after 8 weeks of study termination. Results: The period prevalence of infection in patients and staff was 7.1% and 14.6% respectively. Mortality in patients was 18%, and all staff recovered. Clustering of patients and staff occurred at 3 of 9 centers. Of 26 HIV positive patients, only one contracted the COVID-19 infection and has recovered. Of those infected, seroconversion occurred in 80% of patients and 83% of staff. Seroconversion also occurred in 16% of patients and 37% of staff, who were asymptomatic and COVID PCR negative during the study period. Conclusions: Testing a patient only when symptomatic, identified only 26% (13/50) of infected patients. For every single symptomatic patient who tested positive, there were 3 other asymptomatic infected ones. There was a high seroconversion rates in infected subjects. But antibodies also developed in asymptomatic subjects, indicating silent transmission and antibody generation in this population.

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Citations (1)


... Patients with end-stage kidney disease (ESKD) are also at a higher risk for infection and mortality. [1] These patients are exposed to each other at dialysis facilities with limited social distancing. Managing maintenance hemodialysis (MHD) patients, therefore, remains a challenge due to the risk of cross-infection and the inability to isolate the infected patients. ...

Reference:

A Unified Citywide Dashboard for Allocation and Scheduling Dialysis for COVID-19 Patients on Maintenance Hemodialysis
From Infection to Immunity - Impact of COVID-19 Across Nine Hemodialysis Centres in Mumbai

Indian Journal of Nephrology