Sun Young Lee’s research while affiliated with Seoul National University Hospital and other places

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Publications (202)


Trends in geriatric cancer-related emergency department visits. (A) Proportion of older adults among the total number of cancer-related ED visits. (B) Distribution of age groups for geriatric cancer-related ED visits.
Epidemiologic trends and characteristics of cancer-related emergency department visits of older patients living with cancer in South Korea
  • Article
  • Full-text available

February 2025

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2 Reads

Jung-In Ko

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Sun Young Lee

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We aimed to investigate the demographic characteristics, common chief complaints, and diagnosis of geriatric cancer-related emergency department (ED) visits and trends of ED outcomes. This retrospective observational study included all ED visits in South Korea between 2016 and 2020. The study population was older people ≥ 65 years living with cancer who visited ED with cancer-related problems. The demographics, common diagnoses, and ED outcomes were investigated. A multivariate logistic regression analysis was conducted to investigate factors associated with mortality. Geriatric cancer-related ED (GCED) visits were 746,416 cases over 5 years. The proportion of older adults among cancer-related ED visits increased from 50.1% in 2016 to 55.3% in 2020. The proportion of the “oldest old” (≥ 85 years) increased from 9.6 to 12.1%. For GCED, the ward admission rate after ED treatment was 60.2% and in-hospital mortality rate was 11.8%. Both of these increased with age group (“young old” (65–74), “middle old” (75–84), and “oldest old” (≥ 85 years) groups admission rates: 56.1%, 62.8%, and 68.0%; and mortality rates: 10.0%, 12.7%, and 15.7%, respectively). The most common diagnosis was pneumonia (4.9%). Old age and ambulance use were also associated with mortality. Older adults account for more than half of cancer-related ED visits, and their number is increasing every year. GCED visits are associated with high hospitalization and mortality, especially among the oldest old. It is important to prepare for a rise in GCED visits is necessary.

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Anatomy of the eye.
Workflow for magnetic labelling of (MSC)‐EVs for detection by MRI. EVs are mixed with superparamagnetic iron oxide NPs used as MRI contrast agent and then loaded in EVs by electroporation. Following purification to remove non‐bound SPIOs, labelled EVs are injected at the target site. The SPIO‐EVs will disturb the local magnetic field, leading to loss of MRI signal. By comparing MRI scans made before and after injection the biodistribution of EVs can be determined by their appearance as black spots. SPIO NPs are fully biocompatible and once taken up by host cells, will slowly biodegrade with the elemental iron eventually recycled into the normal body iron pool. Figure courtesy of Dr. Shreyas Kuddannaya. EV, extracellular vesicle; NP, nanoparticle; MRI, magnetic resonance imaging.
A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research

December 2024

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109 Reads

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1 Citation

With an evolving understanding and new discoveries in extracellular vesicle (EV) biology and their implications in health and disease, the significant diagnostic and therapeutic potential of EVs for vision research has gained recognition. In 2021, the National Eye Institute (NEI) unveiled its Strategic Plan titled ‘Vision for the Future (2021–2025),’ which listed EV research as a priority within the domain of Regenerative Medicine, a pivotal area outlined in the Plan. In alignment with this prioritization, NEI organized a workshop inviting twenty experts from within and beyond the visual system. The workshop aimed to review current knowledge in EV research and explore gaps, needs and opportunities for EV research in the eye, including EV biology and applications of EVs in diagnosis, therapy and prognosis within the visual system. This perspective encapsulates the workshop's deliberations, highlighting the current landscape and potential implications of EV research in advancing eye health and addressing visual diseases.








Citations (45)


... Transcriptomic studies revealed detrimental alterations in gene expression in Royal College of Surgeons rats, including essential RPE functions such as phototransduction, retinol metabolism and lipid metabolism were partially reversed. Defective photoreceptor outer segment engulfment due to intrinsic MerTK mutation was partially ameliorated Pollalis, Nair et al., 2024). It was emphasized that RPE-secreted small EVs may play a functional role similar to that of RPE cells. ...

Reference:

A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research
Dynamics of microRNA secreted via extracellular vesicles during the maturation of embryonic stem cell‐derived retinal pigment epithelium

... During the discussion, it was noted that the study of EVs in vision research lags behind, as evidenced by the numbers of publications and clinical trials, as also discussed in depth in a recent publication (Dhodapkar et al., 2024). In addition to collective acknowledgement of the general gaps, needs and opportunities across the EV field, specific considerations were discussed for vision research. ...

An Eye on Extracellular Vesicles: Trends and Clinical Translations in Vision Research

Ophthalmology Science

... Cisplatin (Sigma-Aldrich, St. Louis, MO, USA) was introduced into each well, and the cells were incubated for 72 h. After the incubation period, 10 µL of EZ-Cytox reagent was added to each well, and absorbance was measured at 450 nm using a microplate reader (Bio-Tek, Winooski, VT, USA) [27]. ...

The Effects of ML385 on Head and Neck Squamous Cell Carcinoma: Implications for NRF2 Inhibition as a Therapeutic Strategy

International Journal of Molecular Sciences

... Apart from that, their high diversity seems to be depending also on the source of MSCs, the state of the donor of the MSCs and possibly also whether they are cellular miRNAs or secreted into EVs [57]. A couple of studies observed that miRNA content secreted into EVs differed substantially from the cellular miRNA content, supporting the view that cellular miRNA and EVs mediated miRNAs are differently regulated [78,79]. While dysregulation of cellular miRNAs in senescence has been studied for the last 15 years, the miRNA content of EVs of senescent MSCs and their potential regulatory roles is much less covered. ...

Dynamics of MicroRNA Secreted via Extracellular Vesicles During the Maturation of Embryonic Stem Cell-Derived Retinal Pigment Epithelium
  • Citing Preprint
  • March 2024

... Liu suggested that engineered EVs could be optimized to repopulate trabecular meshwork cells, lower intraocular pressure, regenerate/preserve RGCs and delay the aging effect. The technical innovations in EV isolation and characterization are expected to significantly promote the translational potential of EVs in glaucoma diagnosis, prevention, progression monitoring and treatment follow-up (Weinreb et al., 2016;Leung et al., 2024;Mead & Tomarev, 2020). ...

Isolation and Characterization of Extracellular Vesicles Through Orthogonal Approaches for the Development of Intraocular EV Therapy
  • Citing Article
  • March 2024

Investigative Opthalmology & Visual Science

... Both firms are therefore likely to take precautionary actions to minimize appropriation risk. For example, they may use safeguards (Poppo and Zenger, 2002;Ryu, McCann, and Reuer, 2018;Hanisch et al., 2024) or limit what they share with partners (Katila, Rosenberger, and Eisenhardt, 2008;Kilduff et al., 2024). We also suggest that their expectations regarding collaboration performance are rather low given that it is an arm's-length relationship. ...

Hiding and Seeking Knowledge-Providing Ties from Rivals: A Strategic Perspective on Network Perceptions
  • Citing Article
  • January 2024

Academy of Management Journal

... Home-based multidimensional survivorship programs offer short-term benefits but have uncertain long-term impacts, indicating a need for further investigation. Additionally, the review by Hwang et al. (2023) shows that homebased supportive care (HbSC) programs can improve quality of life, particularly in social and emotional functioning, but their effectiveness varies depending on program components. Despite these benefits, challenges such as the need for adequate home infrastructure, caregiver training, and strong coordination among healthcare professionals persist. ...

Home-based supportive care in advanced cancer: systematic review

Supportive and Palliative Care

... In green demarketing, variations in information strategies can change consumer behavior by raising awareness of environmental issues resulting from purchases, and such interventions are cost-effective and easy to implement. Compared to abstract information, incorporating specific "anti-consumption amplifiers" information within green demarketing advertising has been demonstrated to enhance favorable attitudes toward advertising (Kim et al., 2023;Reich & Soule, 2016) and activate pro-environmental behavior (Verleye et al., 2023). This positive effect is more pronounced when the brand has strong capabilities (Janssen et al., 2022). ...

The Effects of Message Specificity on Outcomes of Corporate Social Responsibility (CSR) Communication: Testing Perceived Social Distance as a Mediator

Sustainability

... To address these issues, auto-segmentation solutions have been developed for breast RT [13,[15][16][17]. These solutions include atlas-[2,4,13] and deep learning (DL)-based autosegmentation [18][19][20][21]. Since use of DL in medical imaging has significantly increased recently [22][23][24][25], this has attracted commercial companies to focus on developing DL-based auto-segmentation (DLAS) software packages such as Limbus AI Inc. Contour (Regina, ) for breast RT planning [29,39]. ...

Assessment of deep learning-based auto-contouring on interobserver consistency in target volume and organs-at-risk delineation for breast cancer: Implications for RTQA program in a multi-institutional study

The Breast

... Retinitis Pigmentosa (RP) is a group of genetic eye disorders characterized by the progressive degeneration of photoreceptor cells in the retina, leading to vision loss [1]. The term "Retinitis Pigmentosa" is a misnomer, as the name might suggest an inflammatory etiology that is not the primary cause of the disease [2]. Non-syndromic RP has a worldwide prevalence of 1: 4000 [3], with prevalence as high as 1:930 in urban, and 1:372 in rural populations of South India [4], hence it is a cause of major concern, especially in India. ...

Retinitis Pigmentosa Masquerades: Case Series and Review of the Literature