Sun-Young Kim's research while affiliated with Seoul National University and other places
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Publications (449)
Background
Little is known about applying machine learning (ML) techniques to identify the important variables contributing to the occurrence of gastrointestinal (GI) cancer in epidemiological studies. We aimed to compare different ML models to a Cox proportional hazards (CPH) model regarding their ability to predict the risk of GI cancer based on...
We examined the associations of clinical characteristics and cause-of-death patterns with mortality in children and young adults (<30 years) with diabetes. We analyzed a nationwide cohort sample from the KNHIS database using propensity score matching from a sample of 1 million people from 2002 to 2013. There were 10,006 individuals in the diabetes...
Background
The COVID-19 pandemic has disrupted malaria control activities globally. Notably, high levels of excess malaria morbidity and mortality in low- and middle-income countries (LMICs) were reported. Although it is crucial to systematically understand the main causes of the disruption to malaria control and synthesize strategies to prepare fo...
Background:
Both exposure monitoring and exposure prediction have played key roles in assessing individual-level long-term exposure to air pollutants and their associations with human health. While there have been notable advances in exposure prediction methods, improvements in monitoring designs are also necessary, particularly given new monitori...
Little is known about the effect of air pollution on Alzheimer’s disease (AD)-specific brain structural pathologies. There is also a lack of evidence on whether this effect leads to poorer cognitive function. We investigated whether, and the extent to which, AD-like cortical atrophy mediated the association between air pollution exposures and cogni...
IGFBP-3 is the main abundant circulating IGFBP and plays an important role in the metabolic effect of IGF-1. We investigated the effects of IGFBP-3 on metabolism in short-term fasting and found that when IGFBP-3 was added to mice, serum triglyceride concentration were significantly enhanced. Fasting also significantly enhanced triglyceride concentr...
Objectives
We investigated the relationships between serum IGF-I/ IGFBP-3 levels and degrees of triglyceride to high-density lipoprotein cholesterol (TG/HDL) ratio in Korean children and adolescents who underwentoral glucose tolerance test.
Methods
children and adolescents without known diabetes were checked an oral glucose tolerance test and coll...
Background and objective:
Air pollution affects clinical course and prognosis of idiopathic pulmonary fibrosis (IPF). However, the effect of individual exposure to air pollutants on disease progression is unclear. We aimed to identify the effect of individual exposure to nitrogen dioxide (NO2 ) and particulate matter (aerodynamic diameter ≤ 10 μm...
Purpose:
An electronic health record (EHR) system known as the e-Tracker was introduced in community health facilities in Ghana and numerous advantages were expected for clinical staff, as evidenced by previous literature. However, little is known about public health officials' views, specifically in low-resource settings. This study aimed to inve...
Plasmid DNA (pDNA) transfection is advantageous for gene therapies requiring larger genetic elements, including "all-in-one" CRISPR/Cas9 plasmids, but is limited by toxicity as well as poor intracellular release and transfection efficiency in immune cell populations. Here, we developed a synthetic non-viral gene delivery platform composed of poly(e...
Objectives
The geographical disparity in the access to essential obstetric services is a public health issue in many countries. We explored the association between timely access to obstetric services and the individual risk of adverse birth outcomes.
Design
Repeated cross-sectional design.
Setting
South Korean national birth data linked with a me...
Muscle atrophy is a major muscle disease, the symptoms of which include decreased muscle volume leading to insufficient muscular support during exercise. One cause of muscle atrophy is the induction of oxidative stress by reactive oxygen species (ROS). This study aimed to identify the antioxidant mechanism of linoleic acid (LA) in muscle atrophy ca...
Background:
Bone marrow-derived mesenchymal stem cells (BMSCs) and bone morphogenetic protein-2 (BMP-2) have been studied for bone repair because they have regenerative potential to differentiate into osteoblasts. The development of injectable and in situ three-dimensional (3D) scaffolds to proliferate and differentiate BMSCs and deliver BMP-2 is...
Particulate matter (PM) air pollution has challenged the global community and the International Agency for Research on Cancer (IARC) classified airborne particulate matter as carcinogenic to humans. However, while most studies of cancer examined a single cancer type using different cohorts, few studies compared the associations of PM between differ...
There has been increasing interest in the neurological impact of particulate matter (PM). However, its association with the incidence of Parkinson's disease (PD) remains unclear. We selected 313,355 participants satisfying inclusion criteria from the National Health Insurance Service-National Sample Cohort based on the nationwide population of Sout...
Background
Recent epidemiological studies of air pollution have adopted spatially-resolved prediction models to estimate air pollution concentrations at people’s homes. However, the benefit of these models was limited in many studies that used existing health data relying on incomplete addresses resulting from confidentiality concerns or lack of in...
Background
Hearing loss is the most prevalent sensory deficit globally, and its prevalence has been growing at a rapid pace, mainly due to the aging population. Although there is plentiful evidence that exposure to air pollutants contributes to oxidative stress and free radical formation in the inner ear is linked to hearing impairment, there is li...
Purpose:
Although lung cancer incidences in female never-smokers have increased, few studies focus on explicit investigation. We aimed to investigate the relationship between long-term exposure to ambient particulate matter sized 10 μm or less in diameter (PM10) and the incidence of lung cancer within different genders and smoking status populatio...
Gonadotropin-releasing hormone agonist (GnRHa) therapy is used to control puberty progression and it preserves height potential in patients with idiopathic central precocious puberty (ICPP). This study evaluated the correlation between weight and height gain at menarche following GnRHa treatment among girls with ICPP and relatively central early pu...
Purpose:
Sentinel lymph node biopsy (SLNB) alone following neoadjuvant chemotherapy (NAC) remains controversial in patients with breast cancer who are initially lymph node-positive. The present study aimed to evaluate the impact of SLNB and axillary lymph node dissection (ALND) on breast cancer recurrence and survival in patients who converted fro...
The incidence and mortality of colorectal cancer (CRC) has increased rapidly in Vietnam, but the economic burden of this disease has never been estimated. We estimate the direct and indirect cost of CRC patients in Vietnam in 2018 using a prevalence-based approach and human capital method. The total economic cost of CRC was VND 3041.88 billion (~$...
Background:
Few studies have investigated air pollution exposure disparities by race/ethnicity and income across criteria air pollutants, locations, or time.
Objective:
The objective of this study was to quantify exposure disparities by race/ethnicity and income throughout the contiguous United States for six criteria air pollutants, during the...
All data used are publicly available. Demographic data are available via IPUMS National Historic Geographic Information Systems [ www.nhgis.org ]; air pollution estimates are available via the EPA CACES project [ www.caces.us ]).
All data used are publicly available. Demographic data are available via IPUMS National Historic Geographic Information Systems [ www.nhgis.org ]; air pollution estimates are available via the EPA CACES project [ www.caces.us ]).
All data used are publicly available. Demographic data are available via IPUMS National Historic Geographic Information Systems [ www.nhgis.org ]; air pollution estimates are available via the EPA CACES project [ www.caces.us ]).
All data used are publicly available. Demographic data are available via IPUMS National Historic Geographic Information Systems [ www.nhgis.org ]; air pollution estimates are available via the EPA CACES project [ www.caces.us ]).
General populations are exposed to numerous environmental pollutants, and it is still unclear what pollutants affect the brain, accelerating brain aging and increasing the risk of dementia. The Environmental-Pollution-Induced Neurological Effects study is a multi-city prospective cohort study that aimed to comprehensively investigate the effect of...
Background
Much of the current evidence of associations between long-term PM2.5 and health outcomes relies on national or regional analyses using exposures derived directly from regulatory monitoring data. These findings could be affected by limited spatial coverage of monitoring data, particularly for time periods before spatially extensive monito...
Background
An indirect adjustment method was developed to control for unmeasured confounders in a large administrative cohort study. A previous study that proposed the indirect adjustment method assessed the validity of the method by simulations but did not consider the direction of bias and scenarios with multiple missing confounders. In this stud...
Background
Kawasaki disease (KD) is a systemic vasculitis of unknown etiology that primarily affects children under 5 years of age. Some researchers suggested a potential triggering effect of air pollution on KD, but the findings are inconsistent and limited by small sample size. We investigated the association between ambient air pollution and KD...
This study explored the association between built environment and semen parameters among men who sought fertility evaluation. We used a data of 5,886 men living in the Seoul capital area whose semen was tested at a single fertility center during 2016–2018. Distance to fresh water, the coast, major roadways, and neighborhood greenness measured by No...
Background
Recent evidence suggests that neurological health could be improved with the intervention of local green space. A few studies adopted cortical thickness, as an effective biomarker for neurodegenerative disorder, to investigate the association with residential greenness. However, they relied on limited data sources, definitions or applica...
Insulin is important in glucose metabolism. However, insulin-like growth factor binding protein (IGFBP) also plays an important role in glucose homeostasis, although the IGF-independent role of IGFBP-3 in the glucose intolerance state is poorly understood. We investigated the relationship of serum IGF-I with total IGFBP-3 levels and glucose toleran...
Background
: Presently, there are no national screening programs for cancer in Vietnam. This study aimed to analyze the cost-effectiveness of an annual colorectal cancer (CRC) screening program from the healthcare service provider’s perspective for the Vietnamese population.
Methods
: The economic model consisted of a decision tree and a Markov mo...
Purpose of Review
Epidemiological studies of short- and long-term health impacts of ambient air pollutants require accurate exposure estimates. We describe the evolution in exposure assessment and assignment in air pollution epidemiology, with a focus on spatiotemporal techniques first developed to meet the needs of the Multi-ethnic Study of Athero...
Brain atrophy is related to vascular risk factors and can increase cognitive dysfunction risk. This community-based, cross-sectional study investigated whether glucose metabolic disorders due to body fatness are linked to regional changes in brain structure and a decline in neuropsychological function in cognitively healthy older adults. From 2016...
Although immune checkpoint inhibitors have significantly improved clinical outcomes in various malignant cancers, only a small proportion of patients reap benefits, likely due to the low number of T cells and high number of immunosuppressive cells in the tumor microenvironment (TME) of patients with advanced disease. We developed a cancer vaccine a...
Introduction:
Early diagnosis of sepsis is paramount to effective management. The present study aimed to compare the prognostic accuracy of presepsin levels and other biomarkers in the assessment of septic shock and mortality risk in cancer patients.
Materials and methods:
A total of 74 cancer patients were evaluated for presepsin, lactic acid,...
Although outdoor air pollution including particulate matter (PM) was classified as carcinogenic to humans based on accumulating epidemiological evidence, these findings were suggested mostly from low-dose environments in North America and Europe. We aimed to examine the association of long-term exposure to PM ≤ 10 and 2.5 micrometers in diameter (P...
Personal dosimeters are used to measure the amount of radiation exposure in individual radiation workers. We aimed to replace existing personal dosimeters and evaluate a real-time scintillator-based dosimeter by monitoring its radiation dose and checking the location exposed to radiation in the workspace. The developed dosimeter measured the radiat...
BACKGROUND
Despite the increasing attention to electronic health record (EHR) system in the field of global health, most African countries still depend on inconvenient and inaccurate paper-based system. Good Neighbors International and Evaluate 4 Health have recently supported Ghana Health Service (GHS) on rollout of EHR system called e-Tracker in...
Background
Despite the increasing attention to electronic health management information systems (HMISs) in global health, most African countries still depend on inefficient paper-based systems. Good Neighbors International and Evaluate 4 Health have recently supported the Ghana Health Service on the rollout of a mobile health–based HMIS called the...
Objective
To investigate the association between antibiotic therapy and the efficacy of intravesical BCG therapy in patients with high-risk non-muscle invasive bladder cancer (NMIBC).
Methods
This study involved the retrospective review of medical records of patients who underwent transurethral resection of bladder tumors for high-risk NMIBC follo...
All data used are publicly available. Demographic data are available via IPUMS National Historic Geographic Information Systems [ www.nhgis.org ]; air pollution estimates are available via the EPA CACES project [ www.caces.us ]).
Background:
Mounting evidence implicates an association between ambient air pollution and impaired reproductive potential of human. Our study aimed to assess the association between air pollution and ovarian reserve in young, infertile women.
Methods:
Our study included 2276 Korean women who attended a single fertility center in 2016-2018. Women...
Objectives:
Deliberate self-poisoning (DSP) is the most common suicide method and can be life-threatening. The purpose of this study was to investigate the factors related to the lethality of DSP and the characteristics of the adolescent group.
Methods:
A retrospective study was conducted on patients who had visited an academic hospital's region...
BACKGROUND
Despite the increasing attention to electronic health record (EHR) system in the field of global health, most African countries still depend on inconvenient and inaccurate paper-based system. Good Neighbors International and Evaluate 4 Health have recently supported Ghana Health Service (GHS) rollout its EHR system called e-Tracker in th...
Objective
This study evaluates the cost-effectiveness of maternal acellular pertussis (aP) immunization in low- and middle-income countries using a dynamic transmission model.
Methods
We developed a dynamic transmission model to simulate the impact of infant vaccination with whole-cell pertussis (wP) vaccine with and without maternal aP immunizati...
Background/objectives:
The Seoul Metabolic Syndrome Management (SMESY) program is a 1-yr lifestyle modification program targeting metabolic syndrome (MetS) in Seoul residents. This study investigated the associations between adherence to dietary guidelines and MetS among the SMESY program participants.
Subjects/methods:
Data of 54,385 participan...
Ozone is known to cause bronchial inflammation and airway hyper-responsiveness via oxidative injury and inflammation. While other ambient air pollutants such as particulate matter (PM) and nitrogen dioxide showed decreasing trends in mean annual concentrations, ozone concentrations have not declined recently in most countries across the world. Shor...
Purpose:
Health-related quality of life (HRQoL) is an important construct in clinical settings, and it is crucial that it should be properly measured. As the EuroQol-5-dimensions-5 levels (EQ-5D-5L) is more effective for such measurement than the 3-level model, data on economic models, clinical studies, and public health evaluations previously col...
Ambient air pollution is associated with prognosis of idiopathic pulmonary fibrosis (IPF) patients. We aimed to identify the impacts of individual exposure to particulate matter with aerodynamic diameter ≤10 μm (PM 10 ) and nitrogen dioxide (NO 2 ) on IPF patients' mortality.
Total 1114 patients (mean age, 65.7 years; male, 80.5%) diagnosed with IP...
Background
While many studies reported the association between long-term exposure to particulate matter air pollution (PM) and cardiovascular disease (CVD), few studies focused on incidence with relatively high-dose exposure using a nationwide cohort. This study aimed to investigate the association between long-term exposure to PM10 and PM2.5 and i...
With increased population and urban development, there are growing concerns regarding health impacts of environmental noise. We assessed the relationship between nighttime environmental noise and semen quality of men who visited for fertility evaluation. This is a retrospective cohort study of 1,972 male patient who had undertaken semen analysis be...
Background: There is growing interest in the potential impact of the physical environment on human fertility. This study aimed to explore the association between built environment and semen parameters among men who sought fertility evaluation .
Methods: This is a cross-sectional study involving 5,886 men living in the Seoul Capital Area whose semen...
Background:
Ambient air pollution can contribute to the development and exacerbation of COPD. However, the influence of air pollution on objective COPD phenotypes, especially from imaging, is not well studied. We investigated the influence of long-term exposure to air pollution on lung function and quantitative imaging measurements in a Korean coh...
As many studies showed the spatial heterogeneity in the association between particulate matter (PM) air pollution and low birth weight (LBW), few studies focused on the variation of local associations at the national scale and related areal characteristics. This study aimed to explore different approaches to estimating local effects of PM with an a...
With urbanization and increasing population density, there are growing concerns regarding health impacts of environmental noise. We assessed the relationship between environmental noise and semen quality of men who visited for fertility evaluation.
Our study adds an evidence of potentially detrimental impact of environmental noise on semen quality...
We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using a live cell–based assay for MOG and AQP4 antibodies. Of...
PurposeAir pollution and smoking are associated with various types of mortality, including cancer. The current study utilizes a publicly accessible, nationally representative cohort to explore relationships between fine particulate matter (PM2.5) exposure, smoking, and cancer mortality.Methods
National Health Interview Survey and mortality follow-u...
Lung cancer is a main cause of cancer death worldwide. In particular, many studies reported geographical disparity of lung cancer mortality (LCM) related to socioeconomic status (SES). While lung cancer is also a leading cause of death in South Korea, few studies investigated geographical disparity attributable to SES. We aimed to explore the geogr...
The immature fruits of Poncirus trifoliate are used as a medicine for the treatment of gastrointestinal disorders, inflammation, and allergies in East Asia. However, their effect on colon cancer cells remains unclear. We investigated the effect of the immature fruit of P. trifoliate extract on colorectal adenocarcinoma. The extract of the immature...
In colorectal cancer (CRC), imaging is important in determining tumor stage, selecting treatment strategies, and in assessing response to therapy. However, some challenges remain with established imaging techniques, such as computed tomography, and with some commonly used response criteria, such as Response Evaluation Criteria in Solid Tumors, whic...
Background:
Fine particulate matter (PM2.5) is associated with negative health outcomes in both the short and long term. However, the cohort studies that have produced many of the estimates of long-term exposure associations may fail to account for selection bias in pollution exposure as well as covariate imbalance in the study population; therefo...
Length scales for spatial variability of air pollution concentrations depend on the pollutant and the location. In this paper, we develop a readily scalable algorithm based on “spatial-increment”, to decompose the air pollution concentration into four spatial components: long-range, mid-range, neighborhood, and near-source. We apply the algorithm t...
Objectives
Likelihood of clinical events occurring within the same anatomical location in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) was retrospectively investigated.
Methods
A total of 236 clinical events in 90 patients with MOGAD from nine referral hospitals were analyzed via logistic regression, and od...
Background:
As scientific findings of air pollution and subsequent health effects have been accumulating, public interest has also been growing. Accordingly, web visualization is suggested as an effective tool to facilitate public understanding in scientific evidence and to promote communication between the public and academia. We aimed to introdu...
Approximately one-third of older people experience at least one fall annually 1,2 and the prevalence increases with age. 3 The consequences of falling include considerable functional limitations, loss of independence, inability to perform daily activities, and psychosomatic factors such as fear of falling. 2 Fear of falling is a common psychologica...