Sujayendra Kulkarni's research while affiliated with BLDE University and other places

Publications (8)

Article
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Background: The most prevalent severe inherited hemorrhagic condition is hemophilia, which means “love of blood.” Hemophilia A and B are caused by a lack or malfunction of the factor VIII and factor IX proteins. Objective: The present study is to determine the prevalence and clinical profile of hereditary coagulation disorder, particularly hemophil...
Article
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Trace elements are essential for the human body’s various physiological processes but if they are present in higher concentration, these elements turn to be toxic and cause adverse effect on physiological processes. Similarly, deficiency of these essential elements also affects physiological processes and leads to abnormal metabolic activities. The...
Article
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Background: Hemophilia B (HB) is an X-linked bleeding disorder resulting from coagulation factor IX (FIX) defects. Over 3,000 pathogenic, HB-associated mutations in the F9 gene have been identified. We aimed to investigate the role of F9 variants in 150 HB patients using sequencing technology. Methods: F9 gene sequences were amplified from perip...
Article
Introduction: Haemophilia is one of the “Bleeder Disorder” that causes abnormal bleeding or poor blood clotting. It occurs due to the defect in the clotting factors even in their functions and in some cases structures are altered. The frequency of haemophilia is 1 in 10,000 and there are approximately 4,00,000 patients all over the world. Haemophil...
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The incidence of breast cancer in India is on the rise. This was indicated by the recent report from Indian Council of Medical Research wherein it was reported that 1 in 22 women in India was likely to suffer from breast cancer in their life time. About 40 to 50% of hereditary breast cancers and most of hereditary breast and ovarian syndromes are t...
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Parkinson’s disease (PD) is a progressive disorder of the brain. It occurs when certain neurons in substantia nigra die or become impaired. Parkinson’s disease is characterized by progressively increasing stiffness all over body, tremor in limbs with difficulty in walking. Parkinson’s disease usually starts at old age and slowly progresses over a p...
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Many genes and signalling pathways controlling cell proliferation, death and differentiation, as well as genomic integrity, are involved in cancer development. Techniques, such as cDNA microarrays, have enabled measurement of the expression of thousands of genes in a single experiment, revealing many new, potentially important cancer genes. Human b...
Article
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In view of conducting HPV vaccination in India it is most important to understand the prevalence of HPV genotypes in this population, not only in squamous cell carcinoma of cervix and oral cavity but also in the general population. In this study we explored the prevalence and distribution of high-risk HPV types 16 and 18 in carcinoma of cervix, sal...

Citations

... Isolation of RNA and labeling the target RNA easy Minikit (Cat-74104) from Qiagen was used to isolate total RNA from tissue samples. RNA integrity analysis, cDNA synthesis, labeling, and microarray methods were carried out sequentially according to Kulkarni et al. [16]. ...
... Every year 75,000 new cases of breast cancer are diagnosed in Indian women (4) . The probability of developing breast cancer during lifetime in Indian women is 1 in 22 as compared to 1 in 8 women in the United States and other developed countries (5) . Genetic differences , the stage of disease at the time of diagnosis , availability of proper and appropriate care are some of the factors which explain the differences in incidence , clinical profile and outcome of the patients (6) . ...
... Meanwhile, three studies from India and two studies from the US reported high-risk HPV DNA prevalence instead of overall HPV DNA prevalence (Bhosale et al., 2016;D'Souza et al., 2007;Elango et al., 2011;Ramshankar et al., 2014;Smith et al., 2004). In India, a vast heterogeneity ranging between 7.4% in Mumbai to 48% from Karnataka was observed in the high-risk HPV DNA prevalence estimate in tissue samples of oropharyngeal cancer cases among men (Bhosale et al., 2016;Elango et al., 2011;Kulkarni et al., 2011). The pooled prevalence of HPV DNA in oropharyngeal cancers in the present meta-analysis (10 studies, n=843 men) was 45% (95% CI 24.0%-66.0%) ...