Sudhakar Godeshala's research while affiliated with Arizona State University and other places

Publications (14)

Article
Background and Objective Chrysin and its derivatives proved to possess potential anti-tumour activity. Materials and Methods A new series of chrysin analogs containing 1,2,3-triazoles with different substituent groups (5a-5l) was designed, synthesized, and evaluated as potential anticancer agents. The synthesized compounds were characterized using...
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Poor strength, infection, leakage, long procedure times, and inflammation limit the efficacy of common tissue sealing devices in surgeries and trauma. Light‐activated sealing is attractive for tissue sealing and repair, and can be facilitated by the generation of local heat following absorption of nonionizing laser energy by chromophores. Here, the...
Article
Simultaneous delivery of small molecules and nucleic acids using a single vehicle can lead to novel combination treatments and multifunctional carriers for a variety of diseases. In this study, we report a novel library of aminoglycoside-derived lipopolymers nanoparticles (LPNs) for the simultaneous delivery of different molecular cargoes including...
Article
Copper ions play an important role in several physiological processes, including angiogenesis, growth factor induction and extracellular matrix remodeling, that modulate wound healing and tissue repair. In this work, copper-loaded alginate fibers were generated and used as surgical sutures for repair of incisional wounds in live mice. Approximately...
Article
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a death ligand that can preferentially induce apoptosis in cancer cells over normal cells. The transmembrane form of TRAIL has been shown to elicit much stronger activity than its soluble counterpart but delivery is a potential challenge. Here, we investigated the potential of amino...
Article
Anticancer drugs exert their effects on cancer cells by deregulating many pathways linked to cell cycle, apoptosis, etc. but cancer cells gradually become resistive against anticancer drugs, thereby necessitating the development of newer generation anticancer molecules. N‐end rule pathway has been shown to be involved in the degradation of many cel...
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Under the heading "Methods-Synthesis of the Bioreducible Modified-PAE (mPAE)", on page 3, line 14-17, there is an error. The quantity unit of PAE and 2-iminothiolane hydrochloride needs to be corrected to mg instead of g.
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Purpose Lung cancer is one of the leading causes of deaths in the United States, but currently available therapies for lung cancer are associated with reduced efficacy and adverse side effects. Small interfering RNA (siRNA) can knock down the expression of specific genes and result in therapeutic efficacy in lung cancer. Recently, mTOR siRNA has be...
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Effective transgene expression in mammalian cells relies on successful delivery, cytoplasmic trafficking, and nuclear translocation of the delivered vector, but delivery is impeded by several formidable physicochemical barriers on the surface of and within the target cell. Although methods to overcome cellular exclusion and endosomal entrapment hav...
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Scaffolds generated from naturally occurring and synthetic polymers have been investigated in several applications because of their biocompatibility and tunable chemo‐mechanical properties. Existing methods for generation of 3D polymeric scaffolds typically cannot be parallelized, suffer from low throughputs, and do not allow for quick and easy rem...
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Targeted delivery of anticancer therapeutics can potentially overcome limitations of poor drug bioavailability, drug resistance, and off-target side-effects that are associated with current chemotherapeutic regimens. Folate receptors are overexpressed on several types of cancer cells including, ovarian, non-small cell lung, triple-negative breast a...
Article
The development of effective drug carriers can lead to improved outcomes in a variety of disease conditions. Aminoglycosides have been used as antibacterial therapeutics, and are attractive as monomers for the development of polymeric materials in various applications. Here, we describe the development of novel aminoglycoside-derived amphiphilic na...

Citations

... Considering that telomerase is widely expressed in human tumors and tumor-derived cell lines, whereas in the normal stem cell this enzyme activity is proportionally low, the inhibition of this enzyme is a strategy for anticancer drug discovery [80]. Considering the antitumor potential of chrysin, and aiming to explore the influence of chrysin hybridization, Noole et al. (2021) synthesized a series of chrysin hybrids linked through the 1,2,3-triazole ring, which were further tested against four cancer cell lines, namely, PC3, prostate PC3-PSMA, MCF-7 and bladder UM-UC-3 [79]. Firstly, OH-7 of chrysin was protected with benzyl or ethyl groups. ...
... The need for developing adhesives with tough tissue bonding strength is compelling as their broad application ranges from wound sealants [1][2][3][4][5][6][7] to tissue repair, [8][9][10][11] as well as hemostasis. [12,13] However, clinical adhesives, such as cyanoacrylates and fibrinogen adhesives, tend to lose tissue adhesiveness upon exposure to water, [14][15][16][17] severely limiting their clinical application. ...
... Given this, to solidify the NADESs, eutectogels enabled by gelling the NADESs (Zeng et al., 2020) are expected to be fabricated using safe, biodegradable and nontoxic backbone materials. As water-insoluble calcium alginate (CA) hydrogels have good biocompatibility, high safety and suitable mechanical properties (Ghosh et al., 2020;Xin et al., 2020), which are widely used in the food and biomedical fields to load functional substances (Gholamian et al., 2021;Song et al., 2020;Wu et al., 2020), NADESs-incorporated CA (NADESs@CA) eutectogels are proposed to be fabricated, hoping to explore a greener way of bio-inspired anti-freezing materials in the frozen food industry. ...
... TRAIL gene therapy promises in situ production of TRAIL for continuous presence at the tumor microenvironment [99,100]. Different types of plasmids were constructed to express TRAILs of various types [86,87,93,101]. ...
... The results reported here advance our understanding of how UBR5, as part of the N-end rule ubiquitination pathway, regulates basic biological processes, its potential role in cancer initiation, progression and maintenance. Importantly, cancers with mutations and/or amplification of genes involved in N-end rule ubiquitination, may represent a unique subset of cancers that are exquisitely susceptible to novel therapeutic interventions [20][21][22][23]. Our data show that UBR5 is highly expressed in multiple lung adenocarcinoma cell lines but is present at reduced levels or absent in normal cells. ...
... SAM RNA may be effective at lower doses for a number of reasons. Whereas DNA needs to enter the nucleus, RNA only needs to enter the cytoplasm to be transcribed (36)(37)(38). The SAM replicon is designed for enhanced amplification of RNA transcripts from which antigen can be expressed and produces dsRNA, which provides a self-adjuvanting effect through activation of pattern recognition receptors (e.g., TLR3, RIG-I, and MDA-5) likely contributing to the efficacy of the SAM vaccine. ...
... The tissue engineering approach provides a solution for the biofabrication of small-diameter vascular grafts to meet the patient-specific requirements [13]. The various tissue engineering techniques used to construct small-diameter blood vessels can be categorized as scaffold-based processing [14][15][16][17][18], decellularization-based processing [19][20][21], molding techniques [22][23][24][25], and cell-sheet engineering [26,27], as shown in Figure 1. These methods have been useful in preclinical trials, but they possess several disadvantages. ...
... Two mechanisms of FA uptake have been identified: 1) reduced folate carrier (RFC1) promotes endocytosis of folic acid in a reduced form by cells and 2) high-affinity folate receptor recognizes folic acid and promotes its oxidation by cells through receptor mediation. Folic acid that enters the cell through this pathway is released into the cytoplasm through endosomal acidification (Godeshala et al., 2016). FR has been shown to be overexpressed in a number of human tumor types, including triple-negative breast cancer, ovarian cancer, and non-small cell lung cancer. ...
... Stimuli responsiveness of nanostructures and their on/off-switch-like behavior appeared to be of interest, in relation to their use as controlled drug delivery systems and in other biomedical applications, such as colon-specific delivery and gene delivery. Amphiphilic PARO-derived nanoparticles were also prepared for drug delivery from mPEG-PAE (methoxy-terminated poly(ethylene glycol)-poly(aminoether)) nanoparticles [159]. They were able to carry significant amounts of the anticancer drug doxorubicin, Figure 18. ...