Sudhakar Godeshala's research while affiliated with Arizona State University and other places

... Considering that telomerase is widely expressed in human tumors and tumor-derived cell lines, whereas in the normal stem cell this enzyme activity is proportionally low, the inhibition of this enzyme is a strategy for anticancer drug discovery [80]. Considering the antitumor potential of chrysin, and aiming to explore the influence of chrysin hybridization, Noole et al. (2021) synthesized a series of chrysin hybrids linked through the 1,2,3-triazole ring, which were further tested against four cancer cell lines, namely, PC3, prostate PC3-PSMA, MCF-7 and bladder UM-UC-3 [79]. Firstly, OH-7 of chrysin was protected with benzyl or ethyl groups. ...

... Those bivalent charge cations can replace calcium without destroying its gelation property. For example, calcium can be replaced with copper cations [97]. A small amount of copper ions was proven to have a profound effect in enhancing tissue sealing and repair, because of the using angiogenesis ability of copper to help form new blood vessels, and its photothermal ability to help the fiber to heat up. ...

... The need for developing adhesives with tough tissue bonding strength is compelling as their broad application ranges from wound sealants [1][2][3][4][5][6][7] to tissue repair, [8][9][10][11] as well as hemostasis. [12,13] However, clinical adhesives, such as cyanoacrylates and fibrinogen adhesives, tend to lose tissue adhesiveness upon exposure to water, [14][15][16][17] severely limiting their clinical application. ...

... It is a p-type semiconductor with a narrow band gap of 1.2 eV and has been reported as a promising material for different applications due to its chemical stability, nontoxic nature, high efficiency, and low production cost [32,33]. In addition, the antibacterial activity of copper ions (Cu 2+ ) has been reported by many researchers [34,35] and Cu 2+ has been reported to possess other valuable biological features such as enhancing the cell activity and proliferation of osteoblastic cells [36], improving the angiogenesis of bioactive scaffolds, wound healing [37], anti-cancer [38,39], and biological imaging probes [40]. Owing to these distinct properties, it is noteworthy to investigate the antimicrobial activities of CuO [41]. ...

... Consequently, DISC triggered the activation of caspase-8. c-FLIP interfered with DISC formation but different natural products and synthetic agents have been shown to inhibit c-FLIP-mediated inactivation of DISC aminoglycoside-derived polymers led to significant shrinkage of the tumors in mice subcutaneously xenografted with UM-UC-3 cancer cells (Fig. 3) [70]. ...

... RAD21 (double-strand-break repair protein Rad21 homolog, also known as SCC1) is a component of the cohesive proteins that are essential for chromosome separation and DNA repair. 22 Recently, RAD21 has been found to be associated with the development and prognosis of malignant tumors. As a target gene of multiple genes or a regulatory gene of other genes, it is also widely involved in human physiological and pathological processes. ...

... The promising features of mTOR siRNA against lung cancer are limited by its poor stability in biological conditions. Synthesis of a modified-poly (aminoether) (mPAE) polymer encapsulation of the mTOR siRNA created stable and bio-reducible nanoparticles which is capable of gene knock down and inducing apoptosis in A549 and H460 lung cancer cells [118]. Based on electrostatic interactions, various cationic polymers are used in the efficient delivery of siRNA. ...

... SAM RNA may be effective at lower doses for a number of reasons. Whereas DNA needs to enter the nucleus, RNA only needs to enter the cytoplasm to be transcribed (36)(37)(38). The SAM replicon is designed for enhanced amplification of RNA transcripts from which antigen can be expressed and produces dsRNA, which provides a self-adjuvanting effect through activation of pattern recognition receptors (e.g., TLR3, RIG-I, and MDA-5) likely contributing to the efficacy of the SAM vaccine. ...

... Tissue engineering techniques provide an alternative approach to fabricate vascular grafts (Catto et al., 2014). Over the last two decades, several tissue engineering approaches have been developed such as molding methods (Vliet and Kuppevelt, 2015;Koens et al., 2010;Kumar et al., 2014), scaffold-based techniques (Awad et al., 2018;Ong et al., 2017b;Dobos et al., 2018), decellularization-based processing (Xiong et al., 2013;Lin et al., 2018), and cell-sheet engineering (Rayatpisheh et al., 2014;Ahn et al., 2015). Although these methods are useful for the development of a tubular vascular construct, there are several limitations associated with these techniques. ...

... Two mechanisms of FA uptake have been identified: 1) reduced folate carrier (RFC1) promotes endocytosis of folic acid in a reduced form by cells and 2) high-affinity folate receptor recognizes folic acid and promotes its oxidation by cells through receptor mediation. Folic acid that enters the cell through this pathway is released into the cytoplasm through endosomal acidification (Godeshala et al., 2016). FR has been shown to be overexpressed in a number of human tumor types, including triple-negative breast cancer, ovarian cancer, and non-small cell lung cancer. ...