Stuart C. Yudofsky’s research while affiliated with American University and other places

... Cognitive function is a mental process which involves several intellectual abilities, such as perception, reasoning, and remembering, while cognitive impairment is the malfunction of cognition or intellectual skills [1]. Cognitive deficits are a core feature of psychotic disorders clinically observed in a range of psychotic disorders, especially in schizophrenia [2]. ...

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Levo-Stepholidine as a Potential Cognitive Enhancer: Insights into Executive Function and Memory Improvements

... The apathy syndrome is characterized by "a loss of motivation, increased passivity, and feelings of lethargy and 'flatness'" (Hales et al, 2008(Hales et al, , p. 1063. As a result of his traumatic experience during the Farhud, Yousef undergoes a profound psychological transformation marked by isolation and alienation. ...

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Iraqi Jews and the Farhud: Trauma and Post-Traumatic Stress Disorders in Ali Bader’s The Tobacco Keeper

... Depression is a mood disorder and is one of the most common mental disorders in society (Malhi and Mann, 2018;Roberts et al., 2019). Depression is characterized by a sense of sadness, pessimism, apathy, and loneliness (Korczak et al., 2023). ...

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Psychodynamic Features of Depressed Patients with Dependent Personality Disorder and Hypokalemia: a Case Report

... Secondary mania is classically associated with lateralization with lesions primarily in the right hemisphere [7]. Multiple brain regions are associated with mania when disrupted or damaged, as in the cases of stroke or traumatic brain injury. ...

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Secondary Mania of Medical and Neurological Disorders

... The phenomenology of schizophrenia is multi-fold. My hypothesis attempts to explain the multiple symptoms of schizophrenia in terms of loss of ego or self boundaries [38] [39] [40]. As already discussed, mutations in the genes that control splicing may result in a "borderless generalization of functional units" ...

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“Too Soon on Earth”: A Biophilosophical Model of Schizophrenia. Some Implications for Humanoid Robots

... There are potential confounders that were too rare in this sample to include in final models, but which may still contribute to unmeasured confounding. One such example is traumatic brain injury, which has been linked to depression [48][49][50], and could conceivably cause stressors such as job loss as a result of symptoms. However, brain injury affected very few individuals in our sample, at least in a measurable way (it is notoriously difficult to measure traumatic brain injury, and our survey only asked about symptoms with reference to an injury during the respondents' most recent deployment). ...

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Stressful life events and incident depression among U.S. military personnel

... Thus, its damage results in anxiety, impulsivity, and aggression, representing unmitigated fight-orflight responses. 19,20 Studies of what are thought to be more advanced cases of CTE have revealed advanced gray and white matter atrophy in multiple areas of the brain, typically most severe in the frontal lobe, specifically in the VMPFC. 13 McKee et al. 2 agree that damage to this area may underlie the lack of insight and aggressive tendencies seen in this population. ...

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A Review of the Role of Chronic Traumatic Encephalopathy in Criminal Court

... They can be distinguished from each other by the time of onset in relation to TBI, with impulsive aggression reflecting a disturbance in self-regulatory behaviour and occurring in the very early recovery period, while episodic aggression occurs several months after the injury. 94 Silver et al. 95 characterized episodic aggression (which they termed 'organic aggression syndrome') as being reactive (triggered by trivial stimuli), nonreflective (not planned), non-purposeful (serves no long-term goals), explosive, periodic (long periods of relative calm) and ego-dystonic (patients express remorse afterwards). ...

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From Trauma to Recovery: Assessing and Managing the Neuropsychiatric Impact of Traumatic Brain Injury

... Meanwhile, in 1887, the German psychiatrist, Emil Kraepelin, coined the term "dementia praecox" which described a degenerative disease of the brain that begins in adolescence and comprises a variety of symptoms which worsen over time (Yudofsky, 2009). In 1911 it would be renamed schizophrenia by the Swiss psychiatrist Eugen Bleuler. ...

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The missing piece: Integrating the expertise of families in psychiatry

... In bipolar disorder, several writers have investigated cognitive impairments across different disorder phases using several clinical instruments, neuropsychological assessments, and neuroimaging modalities for visualizing brain activity (Sackeim et al., 1983). Nevertheless, it is worth noting that the field of research on this subject has not garnered substantial attention, nor has it been well assessed compared to other mental conditions, such as schizophrenia (Martínez-Aran et al., 1999a;Miklowitz, 1992). ...

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Clinical neuropsychological characteristics of bipolar disorder, with a focus on cognitive and linguistic pattern: a conceptual analysis