Steven R Feldman's research while affiliated with University of Southern Denmark and other places

Publications (732)

Article
Background: Patient adherence to topical antipsoriatic drugs is often poor, leading to deficient efficacy. Use of long-term support delivered by dermatological nurses to patients treated with topical drugs may improve outcome. Objectives: To evaluate whether regular support from dermatological nurses improves outcome and treatment adherence in p...
Article
Non-medical switching is when a patient's therapy is switched for reasons unrelated to health outcomes. Dermatologists are regularly affected by non-medical switching, as many of their complex patients are on expensive medications, which become first-line targets for cost-containment. This commentary examines the literature on non-medical switching...
Chapter
The authors of the Integrated ScienceIntegrated science:MultidisciplinarityMultidisciplinarityandInterdisciplinarityInterdisciplinarityinHealthHealth were asked how you would see the future of your field 30 years later. This chapter presents the authors’ views on this subject in 2050. The Al-Samah danceDance. In the above poem, Hushang Ebtehaj says...
Chapter
MedicationMedicationadherenceAdherence is an important topic in clinicalClinicalmedicineMedicine and a crucial factor in patientPatientsoutcomesOutcome. Poor medicationMedicationadherenceAdherence is responsible for more than 100,000 deathsDeath every year in the U.S. alone. By improving adherenceAdherence, the effect on healthHealth status in the...
Article
Background: Psoriasis can greatly impact patients' quality of life. The introduction of new treatments has improved treatment outcomes, but treatment gaps may still exist. Objective: Identify unmet treatment needs in patients with psoriasis. Methods: Participants aged 18 years or older, with an Amazon Mechanical Turk account, who reported diag...
Article
Introduction: Biosimilars are underutilized, and negative perceptions may hinder their acceptance by patients. Psychologic interventions have not been extensively studied in the context of alleviating biosimilar hesitancy. The objective of this study was to assess the effectiveness of psychologic interventions on biosimilar confidence. Methods:...
Article
Objective: To review the pharmacokinetics, efficacy, and safety of recently approved calcipotriene and betamethasone dipropionate (C-BD) cream. Data sources: A literature review was conducted using MEDLINE (PubMed) and ClinicalTrials.gov from 2002 to mid-May 2022. Study selection and data extraction: Articles in English discussing the use of C...
Article
Objective: To review pharmacokinetics, efficacy, and safety of tralokinumab in treatment of atopic dermatitis (AD). Data sources: Literature review was conducted using MEDLINE (PubMed), EMBASE, and ClinicalTrials.gov for articles published between January 2010 and May 2022. Study selection and data extraction: Articles in English discussing tr...
Article
Objective: To review the pharmacokinetics, efficacy, and safety of a newly approved topical Janus kinase 1 (JAK) inhibitor, ruxolitinib (RUX), in patients with atopic dermatitis (AD). Data sources: A literature search was completed May 1, 2022. The term RUX and AD was queried in MEDLINE (PubMed) and EMBASE databases. Study selection and data ex...
Article
Full-text available
Atopic dermatitis (AD) is a chronic inflammatory skin disease that greatly impacts patient quality of life. Type 2 cytokine interleukin (IL)-13 is integral to the pathogenesis of AD. Tralokinumab is a fully human IgG4 monoclonal antibody that specifically targets IL-13, preventing downstream signaling of inflammatory pathways that may contribute to...
Article
Objective: A nationally representative database was used to assess how soon patients were informed to return to clinic after cryosurgical treatment or prescription of topical 5-fluoruracil (5-FU) for actinic keratosis (AK). Methods: The National Ambulatory Medical Care Survey was used to capture diagnoses and medications associated with visits t...
Preprint
BACKGROUND Actinic keratosis (AK) is a common premalignant skin lesion and topical 5-fluorouracil (5-FU) is commonly used field-directed therapy. However, 5-FU is associated with frequent local skin reactions. OBJECTIVE To qualitatively assess experience in those who refuse treatment with 5-FU. METHODS Semi-structured interviews were conducted in...
Article
Hidradenitis suppurativa (HS) can severely impact patients' quality of life. However, its specific impact on participation in everyday social activities is not well characterized. We recruited a cohort of patients with HS to complete a survey assessing the degree of interference HS has on participation in social activities. Patients also completed...
Article
Full-text available
i>Cucurbita moschata , also known as butternut squash, is a common ingredient in numerous seasonal recipes but is an uncommon cause of cutaneous reactions. We present a 28-year-old male who developed dry and flaking skin of his right palm and fingers after coming in contact with butternut squash, which does not typically serve as an allergen that p...
Article
Objective The objective of this article is to review abrocitinib, an oral Janus kinase (JAK) 1 inhibitor, for the treatment of patients with moderate-to-severe atopic dermatitis (AD). Data Sources A literature search of MEDLINE (PubMed) was performed for articles from inception through end-March 2022 using the following search terms: atopic dermat...
Article
Full‐body skin exams (FBSE) involve examination of patients’ skin from head to toe and may be uncomfortable for some patients. While many patients prefer same‐sex providers for pelvic, genital, and rectal exams, desire for same‐sex providers for FBSEs is not well characterized. This may be further magnified when FBSEs are performed by medical train...
Article
Full-text available
Atopic dermatitis’ (AD) systemic involvement is wide-reaching. The cardiovascular and hematological comorbidities of AD have potential for considerable economic and physical burden; however, data surrounding the association between these comorbidities and AD is controversial. This review discusses the cardiovascular and hematological comorbidities...
Article
Objective: We sought to determine the outpatient visit rates for the five most common skin conditions among dermatologists and non-dermatologists. Methods: We conducted a population-based, cross-sectional analysis using the National Ambulatory Medical Care Survey between 2007 and 2016, the most recent years available. Results: The five most co...
Article
Background: While it is known that psoriasis patients have poor adherence to both topical and systemic medications, adherence to methotrexate is not well-characterized, and ways to improve methotrexate adherence have not been addressed. Objective: To evaluate whether a digital intervention improved adherence to oral methotrexate as measured by e...
Article
Alopecia areata (AA) is a condition characterized by nonscarring hair loss. Cases of alopecia areata are most commonly seen in patients under age 30 and are frequently idiopathic. In this report, we discuss a woman in her 50s who developed AA shortly after receiving the Tdap vaccine and after one year of guselkumab therapy.
Article
Background: The process by which drugs leave the bloodstream to enter the skin compartments is important in determining appropriate routes of delivery and developing more efficacious medications. We conducted a general literature review on percutaneous egression mechanisms. Summary: Studies demonstrate that the stratum corneum (SC) is a compartm...
Article
There is limited information of the effect of the COVID-19 pandemic on the general population's perceptions towards teledermatology. This study aims to assess the pandemic's impact on people's willingness to use teledermatology as well as to investigate influencing factors. We recruited 544 participants through Amazon Mechanical Turk (MTurk) and su...
Article
Introduction: Cytokine blockers have revolutionized the management of psoriasis. While efficacious, not all patients respond, and treatment may lose efficacy over time. Janus kinase (JAK) inhibitors target the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) transduction cascade from transmitting cytokine signals in psorias...
Article
Objective The aim of this study is to review the available data on efficacy and tolerability of tazarotene 0.045% lotion. Data Sources A literature search of MEDLINE (PubMed) and EMBASE databases was completed in November 2021. Study Selection and Data Extraction Articles that discussed efficacy, tolerability, and pharmacology of tazarotene 0.045...
Article
Metastases to the face are rare. We report on a patient with a history of renal cell carcinoma who presented with a 1.2cm violaceous papule on his lower lip. Although clinically thought to be a pyogenic granuloma, biopsy revealed metastatic renal cell carcinoma recurring after 7 years of latency.
Article
Introduction The most frequently prescribed first-line treatment for limited (mild-to-moderate) psoriasis is topical corticosteroids, which are associated with a number of adverse effects with long term use. Benvitimod is an aryl hydrocarbon receptor immunomodulator that is both efficacious and tolerable for use in patients with mild to severe psor...
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Full-text available
Teledermatology has been widely adopted during the COVID-19 pandemic as virtual patient care promotes social distancing and decreases viral exposure risk. As teledermatology has become more prominent during this period, it is essential to assess whether virtual visits allow for adequate patient care. To assess perceptions of advantages and disadvan...
Article
Objective Interventions to elicit accountability capitalize on social behaviors to improve adherence but are distinct from reminders. However, little is known about the impact of accountability in reminder-based adherence interventions. Through a literature review, we aim to identify the frequency and effectiveness of accountability in reminder-bas...
Chapter
Psoriasis is a common condition that can be treated with a variety of over‐the‐counter skincare products. The majority of patients with psoriasis have limited, or so called "mild", disease, covering less than 3% of total body surface area. A survey by the National Psoriasis Foundation confirmed both the emotional and physical impact of psoriasis. T...
Article
Full-text available
Acne, atopic dermatitis (AD), and psoriasis are all chronic dermatologic conditions that greatly impact the lives of pediatric patients and their caregivers. The visible nature of these diseases negatively affects the self-image of children early in life as well as their relationships with their families and peers. Physicians recognize the importan...
Article
Full-text available
Background: Psoriasis is a chronic autoimmune skin disorder that can vary in severity and extent of disease. While localized disease can be managed with topical medications, widespread disease often requires systemic therapy including biologics. This medication class targets different components of the immune system and thus modulates disease acti...
Article
Background: Adalimumab (ADA), certolizumab pegol (CER), etanercept (ETA), guselkumab (GUS), ixekizumab (IXE), secukinumab (SEC), and ustekinumab (UST) are biologic medications approved in the USA for the treatment of moderate to severe psoriasis. We examined drug adherence and persistence of patients with moderate to severe psoriasis who initiated...
Article
Purpose: Real-world treatment patterns among psoriasis patients with and without psoriatic arthritis (PsA) newly initiating treatment with a biologic or apremilast were assessed. Patients and methods: MarketScan claims data from adults with psoriasis and ?1 new prescription for secukinumab, adalimumab, ustekinumab, etanercept, or apremilast from...
Article
Full-text available
BackgroundAVT02 (adalimumab) is a proposed biosimilar to Humira®. AVT02 is produced at a 100 mg/mL concentration with a citrate-free formulation.Objectives The aim of this study was to compare the efficacy, safety and immunogenicity of AVT02 versus Humira® in subjects with moderate to severe chronic plaque psoriasis.Methods This double-blind, rando...
Article
Full-text available
Introduction: Adherence to topical treatments for psoriasis is reported to be poor. One key contributing factor is the inconvenience associated with formulations that may be greasy, time consuming to apply, and slow to absorb. There is a paucity of patient-reported outcome measures that evaluate psoriasis patients' perceptions of treatment conveni...
Article
Importance: Psoriasis relapse may involve compensatory T-cell activation pathways in the presence of CD28-CD80/CD86 blockade with abatacept. Objective: To determine whether costimulatory signaling blockade with abatacept prevents psoriasis relapse after ustekinumab withdrawal. Design, setting, and participants: Psoriasis Treatment with Abatace...
Article
Background: Hidradenitis suppurativa patients often seek non-prescription therapies. Objective: To determine the prevalence of alternative medicine use and characterize the differences between patients who report using alternative medications versus those who do not. Methods: We surveyed 67 patients with hidradenitis suppurativa regarding demo...
Article
A patient diagnosed with tumid lupus erythematosus (TLE) was subsequently found to have systemic lupus erythematosus (SLE) after presenting to a tertiary care medical centre with shortness of breath and oedema. In this commentary, we discuss this patient’s presentation and the association between TLE and SLE.
Article
Morgellons disease is characterized by patient reports of fibers embedded in and protruding from the skin. Etiologies from infection to delusion have been endorsed, and treatment guidelines are not well-defined. The objective of this manuscript is to evaluate the existing evidence regarding the etiology and treatment of Morgellons disease in an eff...
Article
Background JAK inhibitors are cytokine modulators that are effective in the treatment of numerous autoimmune diseases. However, given their immunosuppressive effects, they may, at least potentially, increase the risk of severe herpes infection in individuals with atopic dermatitis. Objective To assess the utility of preventative antiviral treatmen...
Article
While topical corticosteroids (TCSs) are safe and effective therapies for atopic dermatitis (AD), poor treatment adherence is a hurdle to successful management. Non‐adherence can be due to TCS phobia, characterized by negative patient feelings and beliefs towards TCSs. The Topical Corticosteroid Phobia (TOPICOP) scale can measure TCS phobia in AD p...
Article
Introduction: Psoriasis is a prevalent disorder of the skin which presents with scaly, red plaques and leads to significant morbidity and mortality. Thus, successful treatment is of great importance to the patient and provider. Objective: Nonetheless, a significant cause of treatment failure may not be incorrect diagnosis or treatment, but rather n...
Article
Full-text available
Vegans and vegetarians often consume foods containing photosensitizers capable of triggering phytophotodermatitis. The potential effect of vegan and vegetarian diets on the response of psoriatic patients undergoing phototherapy is not well characterized. We assessed clinical outcomes of vegan, vegetarian and omnivore adult psoriatic patients underg...
Article
Patients often are apprehensive about starting biologic medications for their psoriasis. Typical fears include anxiety regarding possible side effects and reluctance in accepting their proven efficacy. In this study, we aimed to evaluate patients' willingness to take a biologic medication for their psoriasis if presented with clinical trial evidenc...
Article
Background Adalimumab (ADA), certolizumab pegol (CER), etanercept (ETA), guselkumab (GUS), ixekizumab (IXE), secukinumab (SEC), and ustekinumab (UST) are biologics approved for treatment of psoriasis (PsO) and psoriatic arthritis (PsA). We examined adherence and persistence among PsO patients with comorbid PsA who initiated treatment with any of th...
Article
Background The expanding number of potential treatment options for atopic dermatitis (AD) highlights the need to better understand the treatment preferences of individuals with AD. Objective This study identified attributes that most greatly influenced treatment preferences of adults/adolescents/caregivers of children with mild/moderate/severe AD....