Stephen M Kissler's research while affiliated with University of Colorado Boulder and other places

... Importantly, Tazemetostat, which inhibits the EZH2 catalytic subunit of PRC2, was recently approved to treat epithelioid sarcomas with loss of SWI/SNF complex member SMARCB1 20 . Furthermore, diffuse large B-cell lymphoma growth can be blocked by inhibition of SETD2 in the case of EZH2 hypermorphic mutationmediated drug addiction to PRC2 inhibitors 21 . These findings suggest that disease-associated defective chromatin crosstalk could represent targets of synthetic lethality for successful therapeutic intervention. ...

... athletes also reported faster viral clearance by RT-PCR in individuals with recurrent COVID-19 compared with primary infections (4.9 vs 7.2 days, respectively) [30]. A cohort study in Alaska reported that individuals with previous COVID-19 infections were less likely to have a positive RADT result by day 5 compared to those with primary COVID-19 [25]. ...

... The time period of each phase is drawn can be found in Table S1. For each infected individual, PATAT randomly draws a withinhost viral load trajectory over the duration of infection, which impacts the sensitivity of Ag-RDTs 40 , based on known distributions for Omicron BA.1 41 . Similar viral load trajectories were drawn for both asymptomatic and symptomatic infected individuals 42 using a stochastic model modified from the one previously developed by Quilty et al. 43 A baseline Ct value (Ct baseline ) of 40 is established upon exposure. ...

... Several studies found changes in bacterial and fungal (most commonly Candida species) infection epidemiology, particularly among hospitalized patients [5,10,11]. Additionally, social distancing and the restrictions imposed by governments to quell the spread of SARS-CoV-2 may have affected the spread of other pathogens as they depend on close contact for spread [12]. While epidemiological changes in hospitalized patients have been described, only a few studies investigated epidemiological changes in bacterial and fungal infections on a larger scale or in terms of community spread during the pandemic. ...

... Until now there has been no standardized method for assessing in vivo antiviral effects. Time to viral clearance is an insensitive measure which is highly dependent on baseline viral loads [20]. The PLATCOV study is a platform randomized trial aiming to provide a standardized assessment in vivo of candidate antiviral drugs by measuring rates of viral clearance [21]. ...

... Developmentally-related differences in sleep efficiency might reflect bio-psychosocial changes associated with pubertal stages. In this sense, it is possible that, compared to pre/early pubertal participants, more mature individuals experienced more sleep arousal episodes due to changes in homeostatic mechanisms regulating sleep pressure (expressed as a less robust build-up and decay of sleep pressure), the quality and quantity of social bonds out of the household, social responsibilities (such as farming or house work), freedom to set one's own bedtimes, and shifts in cognitive-emotional states due to ongoing development and maturation of the dopaminergic reward system and prefrontal cortex [8,18,22,62,63]. A decreased sleep efficiency might serve a protective function for the social group, enabling more mature individuals, better prepared than younger individuals to physically respond to nocturnal environmental threats, to monitor the surroundings at night. ...

... The lower relative increases in excess mortality among more frail groups and those with more comorbidities have important implications and suggest that forward mortality displacement might be less of a phenomenon during the post-pandemic period than had been proposed. 29 Although the analysis of the CCI summary score indicated that those with more comorbidities had higher excess mortality on the absolute scale and lower excess mortality on the relative scale, there were some important clinical subgroups that did not follow this pattern. Notably, patients with dementia had the highest excess mortality on both absolute and relative scales, which was previously identified as an important risk group in other healthcare systems, such as that in the UK. 30 Interestingly, patients with metastatic cancer, who are likely to be at greater risk of SARS-CoV-2 infection or severe COVID-19, 31 appeared to have no excess mortality during the first 2 years of the pandemic. ...

... Instead, the increases re ect changes in the local sewage used as the background feed. Macrolide prescription rates in outpatient settings have been shown to have winter/early-spring peaks (35) suggesting this may have been a byproduct of community antibiotic usage. Therefore, we next addressed the potential consequences of changing antibiotic levels on (1) shifts in the abundance of bacteria harboring the resistance genes, and (2), the potential for HGT of contaminantassociated resistance genes. ...

... To validate our hypothesis that isolation may be a selection pressure to further drive the evolution of viral phenotypes, we additionally used the longitudinal viral load of SARS-CoV-2 from the BA.1 subvariant in 49 infected patients 41 (Table S1), and similarly analyzed those data together with the same data for the Delta variant (see METHODS in detail). The individual viral loads for the Delta variant (red) and BA.1 subvariant (green) are described in Fig. S8, and the estimated population parameters are shown in Table S5. ...

... Furthermore, the degree to which potential superspreader events could be important -not just for the initial seeding of Omicron, but for its continued spread -is not captured here. For example, it is possible that the spread of Omicron in other types of communities may be slower if the structure of the social network differs 40 , resulting in fewer opportunities for clustered transmission. Additionally, our work is limited by a few differences between MA and IHEs. ...