Stefanie Förderreuther's research while affiliated with Ludwig-Maximilians-University of Munich and other places

Publications (46)

Article
Full-text available
Background Although good treatment options exist for many headache disorders, not all patients benefit and disability continues to be large. To design strategies for improving headache care, real-world data observing standard care is necessary. Therefore, the German Migraine and Headache Society (DMKG) has established the DMKG Headache Registry. He...
Article
Full-text available
Introduction: The aim of this analysis is to determine whether regular physical activity is associated with less analgesic use in men and women suffering from headache disorders based on population-based cross-sectional data. Methods: We used data from a random general population sample in Germany that comprised 2477 participants aged ≥ 14 years...
Article
Background Triptans are a highly effective substance class in the acute treatment of migraine attacks. They contribute to a substantial improvement in the quality of life and help to reduce the socioeconomic burden of the disease.ResultsSumatriptan is the only triptan that is available for subcutaneous administration. It is primarily indicated in p...
Article
Post-dural puncture headache belongs to the group of secondary headache disorders and is a typical complication of intended or unintended dural puncture. The main symptom is orthostatic headache, which can be accompanied by neurological symptoms such as diplopia depending on the extent of the cerebrospinal fluid leak. The course of this headache is...
Article
Post-dural puncture headache belongs to the group of secondary headache disorders and is a typical complication of intended or unintended dural puncture. The main symptom is orthostatic headache, which can be accompanied by neurological symptoms such as diplopia depending on the extent of the cerebrospinal fluid leak. The course of this headache is...
Article
Aims This is an official interdisciplinary guideline published and coordinated by the German Society for Gynecology and Obstetrics (DGGG), the Austrian Society for Gynecology and Obstetrics (OEGGG) and the Swiss Society for Gynecology and Obstetrics (SGGG). The guideline was developed for use in German-speaking regions and is backed by numerous pro...
Article
Full-text available
Monoclonal antibodies against the calcitonin gene-related peptide (CGRP) receptor (Erenumab) or against CGRP (Eptinezumab, Fremanezumab, Galcanezumab) are new substances for the preventive treatment of migraine. They represent an extension of the therapeutic options, which already exist in migraine prevention. In randomized, placebo-controlled stud...
Preprint
As neck and/or shoulder pain (NSP) frequently occur together with tension-type headache (TTH) and migraine, we explored how concomitant NSP affects perceived treatment responses to an analgesic. An anonymous survey was performed among 895 TTH and migraine sufferers who used the analgesic 400 mg ibuprofen/100 mg caffeine. NSP was relatively abundant...
Article
This article presents secondary headache syndromes caused by life-threatening disease as well as symptomatic headaches requiring immediate treatment to prevent irreversible deficits. Clinical signs and symptoms indicating a secondary headache syndrome are summarized in the so-called SNOOP list (SNOOP: systemic symptoms, neurological symptoms, acute...
Chapter
Trigeminoautonome Kopfschmerzerkrankungen (TAK) sind selten und durch streng einseitige Kopfschmerzen mit ipsilateralen autonomen Symptomen wie konjunktivale Injektion, Lakrimation oder Rhinorrhö charakterisiert. An eine TAK sollte bei frontal, orbital und temporal lokalisierten Schmerzen, ipsilateralen autonomen Begleitsymptomen und einer „Agitati...
Chapter
Kopfschmerzen gehören zu den am häufigsten beklagten Symptomen überhaupt. Die Klassifikationskriterien der Internationalen Kopfschmerzgesellschaft (International Headache Society, IHS) definiert alle Kopfschmerzerkrankungen und bildet die Grundlage zur Einordnung von Kopfschmerzen. In der aktuell dritten Auflage der Internationalen Kopfschmerzklass...
Chapter
Symptomatische oder sekundäre Kopfschmerzen sind keine eigenständige Erkrankung wie z. B. die Migräne, sondern Symptom einer anderen Grunderkrankung. Sekundäre Kopfschmerzen sind insgesamt deutlich seltener als primäre Kopfschmerzen und machen zusammen mit den Neuralgien etwa 8 % aller Kopfschmerzformen aus. Sekundäre Kopfschmerzen können unbehande...
Chapter
Zu dieser Gruppe sehr heterogener und seltener primärer Kopfschmerzerkrankungen zählen der Donnerschlagkopfschmerz, der primäre stechende Kopfschmerz, der Münzkopfschmerz und der schlafgebundene Kopfschmerz. Vor Diagnosestellung dieser Kopfschmerzen ist der Ausschluss einer sekundären Genese erforderlich.
Chapter
Spannungskopfschmerzen (SKS) sind mit Abstand die häufigsten Kopfschmerzen. Grundsätzlich wird zwischen episodischen und chronischen Spannungskopfschmerzen unterschieden.
Article
Episodic tension type headache is considered to be the most prevalent primary headache. If tension type headache occurs on more than 15 days per month for at least 3 consecutive months, it is classified as chronic tension type headache. In recent years, it has become obvious that it is difficult to distinguish between episodic tension type headache...
Article
Full-text available
Background: Headache sufferers in need of professional health care often do not utilize the care available, and factors influencing headache-specific physician consultation are not yet understood. Objectives of this study are (1) to assess self-reported headache-specific physician consultations and (2) to identify headache-related and sociodemogra...
Article
Full-text available
ZUSAMMENFASSUNG Monoclonal antibodies against the calcitonin gene-related peptide (CGRP) receptor (erenumab) or against CGRP (eptinezumab, fremanezumab, galcanezumab) are new substances for the preventive treatment of migraine. They represent an extension of the therapeutic options which already exist in migraine prevention. In registration studies...
Article
Full-text available
IntroductionA fixed dose combination (FDC) of ibuprofen 400 mg and caffeine 100 mg has been shown to be more effective than ibuprofen 400 mg alone for the treatment of acute postoperative dental pain in a phase III randomised controlled trial. A post hoc subgroup analysis of the primary data from an active-/placebo-controlled, double-blind, single-...
Article
Full-text available
Background: Reliable population-based data on the prevalence and characteristics of primary headache across the lifespan are essential. However, robust data are lacking. Methods: We utilized questionnaire data from a random general population sample in Germany, that comprised 2,478 participants aged ≥14 years. A standardized questionnaire addressin...
Article
ZUSAMMENFASSUNG Trotz hoher Prävalenz von Kopfschmerzerkrankungen und bedeutender Beeinträchtigung vieler Betroffener ist die Versorgung von Menschen mit häufigen Kopfschmerzen in Deutschland unzureichend. Zur Verbesserung der Versorgung und Erhebung von Daten zur Versorgungs- und Kopfschmerzforschung richtet die Deutsche Migräne- und Kopfschmerzge...
Chapter
Der IHA ist definiert als irreversibel erloschene Gesamtfunktion des Gehirns. Dabei werden die Atmung und die Herz- und Kreislauffunktion durch die Intensivtherapie künstlich aufrechterhalten. Der IHA ist ein sicheres Todeszeichen. Da jedoch die allgemein bekannten sicheren Todeszeichen fehlen, erfordert die Feststellung des IHA besondere Kenntniss...
Article
Full-text available
Background: Maintenance of effect following treatment with galcanezumab compared to placebo in adult patients with episodic or chronic migraine was evaluated. Methods: In 2 similarly designed studies of patients with episodic migraine (6 months) and 1 study of patients with chronic migraine (3 months), patients randomized in a 1:1:2 ratio receiv...
Article
Für den Beitrag MMW 2018;160(S1):70–1 fehlt die Literaturliste.
Article
Große Hoffnungen verbinden viele Schmerzpatienten mit dem Einsatz von Cannabinoiden. Doch halten diese Extrakte, was sie versprechen? Wie sieht die Datenlage speziell bei der Indikation Kopfschmerzen aus?
Chapter
Der IHA ist definiert als irreversibel erloschene Gesamtfunktion des Gehirns. Dabei werden die Beatmung und die Herz- und Kreislauffunktion durch die Intensivtherapie künstlich aufrechterhalten. Beim irreversiblen Hirnfunktionsausfall (IHA) ist die Gesamtfunktion des Gehirns erloschen, während die die Herz- und Kreislauffunktion unter künstlicher B...
Article
Die neue „Hirntodrichtlinie“ umfasst neue Qualifikationsanforderungen an die Ärzte, neue ergänzende Methoden und detaillierter ausformulierte Vorschriften an den Untersuchungsablauf. Für den Arzt, der mit diesen Änderungen noch nicht vertraut ist, birgt die überarbeitete Richtlinie aber auch einige Fehlermöglichkeiten, die zu beachten sind.
Article
Die Versorgung von Schmerzpatienten muss verbessert werden, das ist keine Frage. Doch kann dies nur interdisziplinär gelingen, wie die Spitze der DMKG findet.
Article
Inzidenz und Symptomatik von Krankheiten ändern sich mit dem Alter. Das gilt besonders für Kopfschmerzerkrankungen. Wie Sie — ausgehend von einer gezielten Anamnese und körperlichen Untersuchung — bei alten Kopfschmerzpatienten am besten diagnostisch vorgehen und welche Differenzialdiagnosen auszuschließen sind, fasst der folgende Beitrag zusammen.
Article
Ophthalmoplegic migraine (OM)/recurrent painful ophthalmoplegic neuropathy (RPON) is a rare disease consisting of recurrent unilateral headache accompanied or followed by ipsilateral ophthalmoplegia. Because MRI findings suggest neuropathy and the relationship to typical migraine remains unclear, the disease has been renamed from "ophthalmoplegic m...
Article
Kopfschmerzen im Alter sind häufig. Sie bedürfen einer besonders sorgfältigen Diagnostik zum Ausschluss symptomatischer Verläufe. Ihre Therapie erfordert die Berücksichtigung altersspezifischer Besonderheiten im Stoffwechsel und von Begleiterkrankungen sowie deren oft umfassende Begleitmedikation.
Article
Zur Prophylaxe und Therapie der Migräne steht heute ein reich bestücktes medikamentöses Arsenal zur Verfügung. Knifflig kann die Behandlung allerdings in besonderen Situationen wie einer Schwangerschaft oder bei Vorliegen weiterer Erkrankungen werden. Im folgenden Beitrag erhalten Sie hierfür das nötige Know-how.
Article
Full-text available
Die Symptomkombination Schwindel, Gleichgewichtsstörungen und Migräne gerät immer mehr in den Fokus des klinischen und wissenschaftlichen Interesses. Jeder 2.–3. Migränepatient hat im Rahmen mindestens einer seiner Migräneattacken bereits Schwindel oder Gleichgewichtsstörungen erlebt. Für einige der betroff enen Pa tienten steht der Schwindel sogar...
Article
PurposeTo investigate the efficacy of prednisone for treatment of withdrawal headache in patients with medication overuse headache (MOH).Patients and methodsIn this prospective double-blind, placebo-controlled, parallel designed multicentre trial, 96 consecutive patients with MOH were randomized to withdrawal treatment with either 100 mg prednisone...
Article
Alle Syndrome der trigemino-autonomen Kopfschmerzen sind durch sehr starke, streng einseitige und meist kurze Schmerzattacken gekennzeichnet. Wesentliches klinisches Unterscheidungskriterium innerhalb dieser Gruppe sind die Attackendauer und -frequenz. Ihre charakteristischen autonomen Begleitsymptome erlauben die Abgrenzung von anderen primären Ko...

Citations

... In the present study, we developed a DL-based technique for classification of participants with migraine, acute PTH (APTH), or persistent PTH (PPTH) vs. HC followed by an automated feature extractor pipeline that identified brain regions affected by migraine and PTH. Migraine, a primary headache, affects about 12% of the general population, is a A C C E P T E D M A N U S C R I P T 5 substantial cause of disability, and a common headache type for which individuals seek care in the outpatient clinic [13][14][15] . PTH is amongst the more common secondary headache types, is the most common symptom immediately following mild traumatic brain injury (mTBI), is often persistent, and typically has symptoms that overlap with those of migraine [16][17][18][19][20] . ...
... Inactive people were found to have a higher prevalence of analgesic use. This was in line with the findings of a recent article that found a lower use of analgesics, especially in women, in the German migraine population [52]. ...
... 3) острое внезапное начало; 4) появление или ухудшение цефалгии в возрасте 50 лет и более; 5) при наличии ГБ ранее в анамнезе -изменение интенсивности, болевого паттерна, новые характеристики боли [19]. Не следует ориентироваться на интенсивность болевого синдрома, при выявлении одного из представленных критериев следует обязательно исключить вторичный генез ГБ с помощью методов нейровизуализации (компьютерная томография, магнитно-резонансная томография головного мозга) и, при необходимости, с помощью люмбальной пункции (субарахноидальное кровоизлияние, инфекции) [20]. Также важен осмотр офтальмолога на предмет повышения внутриглазного давления, выявления изменений на глазном дне. ...
... Regarding pain intensity and duration of TTH, findings are inconsistent [2,5]. However, as the majority of findings support the concept, regular physical exercise is recommended for the prevention of migraine and TTH in national and international guidelines [6][7][8]. ...
... Imaging data and blood samples are currently not collected, which precludes some types of analysis but makes participation easier for both physicians and patients. It must be noted that different from population surveys which are also a field of research of the German Migraine and Headache Society [29], registry data can never be representative for the expression of the disorder in the general population. First, persons with headache that do not see a physician are not captured at all. ...
... However, patients who were treated with a CGRP mAb in the last 3 months had more severe interictal burden than patients who had never received a CGRP mAb, even after adjusting for migraine frequency and impact of migraine attacks. Patients who are treated with CGRP mAb are commonly thought to be more severely impacted than other patients, as they need to qualify for CGRP mAb treatment, for example by having refractory disease [40,41]. To our knowledge, interictal burden is not regularly considered when treatment benefits are assessed, and the relationship between treatment and interictal burden is not well understood. ...
... Second, given the low level of CP intensity at baseline, participants may have had difficulty perceiving changes after each intervention. These latter findings are supported by previous work showing more moderate to severe pain at baseline predicts more significant responses to analgesic interventions [35,36]. ...
... This risk of treatment discontinuation looks lower in comparison to other oral treatments for migraine prevention [31][32][33] and similar to the risk observed with monoclonal antibodies against CGRP ligand or target [34]. The specificity of action of the agents targeting the CGRP pathways may explain the overall better tolerability profile of this drug class [35]. ...
... As mentioned above in the migraine clinical trial guideline (23), a migraine attack can last for several days and consist of several episodes with various durations, each episode of a migraine attack can be temporarily relieved by acute medication. In addition, analgesic consumption is associated with headache history duration (49) and age (50). Therefore, the reduction in pain intensity, migraine frequency, and the times of acute medication consumption are not necessarily consistent. ...
... However, the recent introduction of calcitonin gene-related peptide (CGRP) antagonists has changed the treatment paradigm for patients requiring migraine prevention. Treatments targeting CGRP typically have a more rapid onset of action [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] with no or minimal interim period between treatment initiation and full onset of efficacy, and these attributes have the potential to decisively change patient management. Thus, the ability of clinicians to describe the response trajectory of a particular preventive treatment agent at an early stage could accelerate management decisions related to continuation of that specific treatment, and interim use of acute medication. ...