Stefan Timmermans’s research while affiliated with University of California, Los Angeles and other places

... Others have pointed to the discretion that doctors exercise in generating and interpreting diagnostic knowledge (Armstrong and Hilton, 2014;Kaufman et al., 2024). For example, analysing the use of genetic tests in cardiology, Kaufman et al. (2024) showed that respective test results may create epistemic disruptions when reconciled with patients' symptoms and medical histories. ...

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Caring around and through medical tests in primary care: On the role of care in the diagnostic process

... It does not. What is required is nothing short of social autopsy (Klinenberg, 1999;Timmermans and Prickett, 2021); what can deaths which are both quantitatively routine and qualitatively fraught reveal about the way that society has lived and functioned? Through the social post-mortems presented here we find sickness and maladies of the most endemic kind. ...

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The New Normal? Ordinary Deaths and Marginalised Mortalities in Extra ordinary Times

... Here, problem formulation entails an explanation of why the currently (unfavorable) state of the world has occurred, which in turn enables imaginative efforts at solving it (Baer, Dirks, & Nickerson, 2013Bhardwaj, Mahoney & Nickerson, 2023. Framing entrepreneurial strategy formation as a problem-solving process emphasizes the importance of context for originating strategies through imagination, giving rise to abductive reasoning (Sergeeva et al., 2021), and further opens up to ideas from design sciences (Dimov, 2021;Rindova & Martins, 2021, 2022, semiotics (e.g., Tavory & Timmermans, 2022), or artificial selection (Levinthal, 2017(Levinthal, , 2022. This perspective, in sum, raises interesting questions about the prerequisites and the type of reasoning that entrepreneurs rely on to derive plausible and warranted assertions, and how they decide to forge ahead (Dewey, 1938;Foss & Klein, 2012). ...

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Pragmatist Foundations of Research on Entrepreneurial Strategy

... Even the much-discussed challenge of uncertainty continues to be newly actualized. Expansion of genetic testing generates new scope for results where significance is uncertain (Burke et al., 2022), and as knowledge advances, previously collected genetic data may offer new or different information with potential implications for patients whose results have effectively changed (Clift et al., 2020;Kaufman et al., 2023;Singer et al., 2019;Walsh et al., 2024). This is no less a concern in genetic counseling. ...

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Interpretative phenomenological analysis and genetic counseling

... This means that individuals at risk for later-or adult-onset ASMD may be diagnosed shortly after birth [48]. The onset of signs or symptoms for the late-onset subtypes is variable, and the initiation of treatment depends on the occurrence of the first signs and symptoms [1], so there is a risk of needless anxiety and unnecessary medical intervention and stigmatization in patients who may remain asymptomatic until adulthood [49]. • Neurologic form: The severe, rapidly progressive neurodegenerative manifestations typical of ASMD type A are not amenable to current therapies, which are unable to cross the blood-brain barrier, so treatment for ASMD type A is limited to supportive therapy [29,48]. ...

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Newborn Screening for Acid Sphingomyelinase Deficiency: Prevalence and Genotypic Findings in Italy

... For example, of the three sources of standards for organising the operation of universities namely; academic oligarchy, state and market, the main source in Tanzania is the state. Therefore, in this study, the definition of standards borrows the definition provided by [23] as the state initiated bureaucratic, administrative guidelines carrying the legal and regulatory power for the aim of constructing individual and collective parameters that should be complied with during the establishment and governance of among other things, the teaching and learning milieus across universities. In the context of Tanzania, the link between the universities standards and the operating milieus in universities can be explained by the Universities Act No. 7 of 2005 and the Tanzania Commission for Universities (TCU) as follows. ...

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Universities with standards but not standard universities: students and academics reflection of university operating standards in Tanzania

... The "return of results", whether incidental findings or general analyses, may also play a role in people's willingness (or not) to share their data and samples. However, the social and personal implications of genomic analyses, human biomonitoring results, and incidental findings are broad and often not anticipated by cohortees [46,50]. (3) Future studies should also address those who declined to participate and focus on a better understanding of unwillingness and, ultimately, meaning of non-participation as those might differ from the meaning of and motivation for participation. ...

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Willingness to participate in a personalized health cohort – insights from the swiss health study pilot phase

... 10,11 Sometimes, doctors feel uncomfortable advising patients regarding VUS, and patients report a range of reactions, ranging from rapid leave to long-term anxiety. [12][13][14] Therefore, it is important to minimize the recurrence of VUS. The most important strategies to decrease the reporting rate of VUS is to do the best to improve the variant assessment by manual adjustment, and to reevaluate any VUS over time and, possibly, reclassify them based on new data provided by the scientific and medical community, as recommended by the ACMG for 15 years. ...

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Variant reclassification over time decreases the level of diagnostic uncertainty in monogenic obesity: Experience from two centres

... We then organized team meetings to clarify and test the adequacy of this coding. Although this framework predetermined our codes, this was counterweighted in the second step of analysis, in which a more "abductive" research approach (Tavory & Timmermans, 2014) was used. In abductive research, a pragmatic back-and-forth between theory and empirical data deliberately focuses on both categories predetermined by theory and themes that emerge from the data (in our case, the themes of uncertainty or of financial worldview). ...

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Morality in Times of Uncertainty: The Moral Grounding of Impact Investing Asset Managers

... This finding aligns with a U.S. study showing that church doctrine can marginalize grieving women, such as by refusing baptism requests, exacerbating their trauma and sorrow (Cacciatore, 2010). The similarity of the finding might be due to restricting individuals from expressing their grief due to religious and cultural norms that discourage the outward display of sorrows and become an obstacle for coping following a fetal loss (Timmermans, 2022). ...

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Coping Strategies Following Fetal Loss Among Women Who Gave Birth in Selected Health Facilities in Eastern Ethiopia: A Phenomenological Study