Stanislav Reims’s research while affiliated with UNIVERSITY OF GHANA SCHOOL OF MEDICINE AND DENTISTRY and other places

Swiss albino mice were trained to take the food from the food magazine in a conditioning chamber. Light for 10 sec acted as a conditioning stimulus. When the mice were fully trained, they were injected intraperitoneally by a brain extract from untrained mice which Puromycin was administered intracranially. After the injection of the extract of Puromycin affected brains, the performance of the trained mice in the experimental space decreased almost to the performance of untrained animals.

The effect of 0.5-M hydroxylamine injected intracranially on a passive-avoidance task was followed in mice. Hydroxylamine administered 24 h before the acquisition trial or earlier had no effect on performance of animals. Hydroxylamine injected 2 h before the acquisition trial impaired the performance of animals tested 24, 48, 72 h, or 1 week later. Hydroxylamine injected 1, 2, or 24 h later interfered with the performance of animals, too. The later hydroxylamine was injected, the later the impairment of performance of animals appeared. The effect of hydroxylamine is probably associated with the “mutagenic” action of the drug on activated DNA.